Kinetics of PKCe Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKCe Translocation in HeLa Cells
Dysregulation of PKCe is involved in several serious diseases such as cancer, type II diabetes and Alzheimer’s disease.Therefore, specific activators and inhibitors of PKCe hold promise as future therapeutics, in addition to being useful inresearch into PKCe regulated pathways. We have previously described llama single chain antibodies (VHHs) that specificallyactivate (A10, C1 and D1) or…
Real-Time Label-Free Monitoring of Drug- or Nanoparticle-Cell Interactions
Efficient drug delivery is one of the major challenges in modern pharmaceutical research. There is a constant need for developing new formulation strategies for new drug delivery systems because new chemical entities tend to have low solubility, and biotechnology drugs (e.g., DNA, oligonucleotides, antibodies, and proteins) permeate poorly to the target sites, limiting or even…