We offer a wide range of sensor slides manufactured according to high quality standards
All BioNavis sensors are cut to 12х20 mm size to fit into the BioNavis sensor slide holder and thus sensors are compatible with all the SPR Navi™ and MP-SPR Navi™ instruments.
Please see our selection below and choose the best sensor surface for your measurements.
Sensors for biomolecular interactions
A wide range of functionalized sensors is available for life science research and biosensor development. Select the most advantageous surface depending on the functional groups of the ligand such as amine, thiol, biotin or histidine. Optimize also the surface binding capacity depending on the size of the analyte molecules such as small molecules, antibodies, viruses or nanoparticles.
3D carboxymethyl dextran sensors CMD-3D
3D carboxymethyl dextran sensors coated with dextran hydrogel layer of low, medium or high density. Medium density (3DM) is recommended for most biological assays like protein-small molecule or protein-protein interactions.
Planar carboxymethyl dextran CMD-2D
Planar carboxymethyl dextran coating (less than 5 nm) allowing immobilization of ligands in a single monolayer. Much lower binding capacity surface as compared to CMD-3D sensors, recommended for binding of high molecular weight analytes such as antibodies or nanoparticles.
Custom carboxymethyl dextran
Custom thickness and density of CMD sensors for a wide variety of biomolecular interactions (subjected to availability). Select optimal CMD thickness and density based on the size and molecular weight of the analyte. In principle the smaller the analyte is, the thicker and the denser hydrogel is needed.
NID sensors are Ni chelator modified carboxymethyl dextran surfaces which allows capturing of His6-tagged ligand on a sensor through complex formation with transition metal ions (Ni2+). Binding is reversible and His6-tagged ligand can be removed using chelating agent (e.g. EDTA). Tens up to hundred regenerations can be carried out without significantly affecting the surface capacity. This means that same sensor can be used for several ligand molecules.
Regenerable Avidin -kit
Biotinylated sensor functionalized with the newest technology. Regenerable avidin allows reversible binding of biotinylated ligands. Biotinylation enables control of ligand orientation on the surface. Surface is planar with moderate binding capacity and thus it is suitable for analytes larger than 10 000 Da or for small molecules in indirect assays. For direct measurements of small analytes on biotinylated ligand high binding capacity streptavidin surface is recommended. Avidin and thus biotinylated ligand can be removed from the surface using regeneration solution. Tens up to hundred regenerations can be carried out without significantly affecting the surface capacity. This means that the same sensor can be used for several ligand molecules.
Other standard functionalizations
Functional coatings include the following:
- Protein A/G fusion protein immobilized on a CMD-2D sensor Suitable for work with a broad variety of IgG. Other CMD densities available on request.
- Biotin functionalized sensor slides: 2D monolayer (PEG) or medium density 3D CMD hydrogel.
- Streptavidin functionalized sensor slides: Streptavidin covalently immobilized on a CMD-2D sensor. CMD-3D sensor available on request.
Gold sensor slide coated with a customized polymer coating
- Carboxymethylcellulose hydrogel (CMC)
- Agarose (AG) hydrogel
- Alginate (AL) hydrogel
- Gelatin hydrogel (GEL)
- Polyethyleneglycol (PEG)
- Poly-L-lysine (PLY)
- Pectin hydrogel (PC)
- Heparin. Thin hydrogel (HEP)
- Hydrophobic planar alkyl layer (HPP)
- Saccharide layer, dense 2D surface (OHP)
- Hydrazide modified linear polycarboxylate hydrogel (HZC)
- Disulfide modified carboxymethyldextran hydrogel (TD)
(several surface capacities available)
Custom functionalizations are available on request (subjected to availability)
Metal sensor slides
Metal sensor slides contains glass substrate coated with a metal layer. Depending on application, they contain adhesion layers such as 2 nm of Chromium or Indium tin oxide (ITO). Use metal sensors as they are or functionalize them ex situ. suitable methods include: spin-coating, atomic layer deposition (ALD), chemical vapour deposition (CVD), Langmuir-Blodgett (LB), spin coating. Metal sensor slides are typically used for biosensor development, thin film characterization and cell studies.
Gold sensor slides
Gold sensor slides provide a versatile platform for many chemistries such as thiols. The surface is highly stable which makes it the most widely used metal sensor. 50 nm gold layer is adhered on sensors with 2 nm layer of chromium. Typically, gold surface can be cleaned using ammonium hydrogen peroxide wash or in UV-ozone chamber and re-used multiple times. Application areas include thin film deposition, biomaterial characterization as well as growth of cell monolayers.
Other metal sensor slides and application areas
- Silver (Ag) sensor slides – Antimicrobial coatings, electrochemistry
- Aluminium (Au) sensor slides – Electrochemistry, energy
- Platinum (Pt) sensor slides – Electrochemistry, energy
- Copper (Cu) sensor slides – Antifouling, antimicrobial coating, electronics, graphene
- Nickel (Ni) sensor slides – Corrosion, medical devices
- Chromium (Cr) sensor slides – Coatings, electronics
- Rhodium (Rh) sensor slides – Electronics, optics
Oxide sensor slides
Oxide inorganic sensor slides contain functional coating on top of plasmonic (typically gold) layer. Sensors can be used as they are or further coated ex situ. Suitable methods include:
- Atomic layer deposition (ALD)
- Chemical vapour deposition (CVD)
- Langmuir-Blodgett (LB), spin coating
Often inorganic sensors can be cleaned and re-used several times using soft cleaning procedures.
Silicon dioxide (SiO2) layer on gold – Coatings, especially antifouling, glass-like chemistry for bioassays, deposition of lipid bilayers, nanocellulose
Titanium dioxide (TiO2) layer on gold – Medical implants, biomaterials
Aluminium oxide (Al2O3) layer on gold– Materials, environmental applications
Indium tin oxide
Indium tin oxide (ITO) on gold – Solar cells, semiconductors
Hafnium oxide (HfO2) on gold – Semiconductors
Zinc sulfide (ZnS) on gold – Materials, energy applications
Titanium nitride oxide
Titanium nitride oxide (TiNO) – Coatings
Custom inorganic sensor
Inorganic coatings includes: AlN, ZnO, Ta2O5, ZrO2,
GdOS, TiN, TiAlCN, CuO, CeO2, MgO, In2S3, In2O3, NiO, Polymethylmethacrylate (PMMA),
Polymer sensor slides
Custom polymer sensor slides
For microfluidics, antifouling, medical devices and separation
- Polystyrene (PS)
- Polymethylmethacrylate (PMMA)
- Polydimethylsiloxane (PDMS)
Glass sensor slides
Uncoated glass sensor slides
Uncoated glass sensor slides are available for deposition and characterization of thin metal (plasmonic) coatings.