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Real-time adsorption of optical brightening agents on cellulose thin films

Publication year: 2021
Authors: C. Sampl a,b, S.Eyley c, W. Thielemans c, U.Hirn a,b,1, S.Spirk a,b
Published in: Carbohydrate Polymers, Vol. 261 (2021), 117826
Optical brightening agents (OBAs) are commonly used in textile and paper industry to adjust product brightness and color appearence. Continuous production processes lead to short residence time of the dyes in the fiber suspension, [...]

One dimensional magneto-optical nanocomplex from silver nanoclusters and magnetite nanorods containing ordered mesocages for sensitive detection of PD-L1

Publication year: 2021
Authors: Xing Huang a,1 Zhao-huan Zhang b,1 Jie Chen a,c, Zhihui Mao a,d, Han Zhu a, Yawen Liu c,d,Zhongzheng Zhu e, Hongxia Chen a
Published in: Biosensors and Bioelectronics, 2021, Vol. 189, p. 113385
Programmed death ligand 1 (PD-L1) is a typical immune checkpoint protein, whose up-regulation on the membrane of different tumor cells inhibits the immune response f T cells and leads to the escape of tumor cells. [...]

Effect of laminin, polylysine and cell medium components on the attachment of human hepatocellular carcinoma cells to cellulose nanofibrils analyzed by surface plasmon resonance

Publication year: 2021
Authors: Xue Zhang a, Tapani Viitala b,1, Riina Harjumäki a,b, Alma Kartal-Hodzic b, Juan José Valle-Delgado a, Monika Österberg a
Published in: Journal of Colloid and Interface Science, Vol. 584 (2021), p. 310-319
The development of in vitro cell models that mimic cell behavior in organs and tissues is an approach that may have remarkable impact on drug testing and tissue engineering applications in the future. [...]

Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides

Publication year: 2021
Authors: J. Ashley 1,2, A.-L. Schaap-Johansen 1, M. Mohammadniaei 1, M. Naseri 1, P. Marcatili 1, M. Prado 2, Y. Sun 1
Published in: Nucleic Acids Research, 2021, Vol. 49, Issue 2, p. 1065–1074
Terminal deoxynucleotidyl transferase (TdT) enzyme plays an integral part in the V(D)J recombination, allowing for the huge diversity n expression of immunoglobulins and T-cell receptors [...]

A designer FG-Nup that reconstitutes the selective transport barrier of the nuclear pore complex

Publication year: 2021
Authors: Fragasso A. 1, de Vries H.W. 2, Andersson J. 3, van der Sluis E.O. 1, van der Giessen E. 2, Dahlin A. 3, Onck P.R. 2, Dekker C. 1
Published in: Nature Communications, 2021, Vol. 12, 2010 (2021)
Nuclear Pore Complexes (NPCs) regulate bidirectional transport between the nucleus and the cytoplasm. Intrinsically disordered FG-Nups line the NPC lumen and form a selective barrier, where transport of [...]

Combining Chemical Functionalization and FinFET Geometry for Field Effect Sensors as Accessible Technology to Optimize pH Sensing

Publication year: 2021
Authors: D.Rani 1, S.Rollo 1,2, W.Olthuis 2, S.Krishnamoorthy 1, C.P.García 1
Published in: Chemosensors 2021, Vol. 9(2), 20
Field Effect Transistors (FETs) have led the progress of applications measuring the acidity in aqueous solutions thanks to their accuracy, ease of miniaturization and capacity of multiplexing. [...]

Characterisation of a unique linker segment of the Plasmodium falciparum cytosol localised Hsp110 chaperone

Publication year: 2021
Authors: G. Chakafana a,b, P.T.Mudau a, T.Zininga a,c, A.Shonhai a
Published in: International Journal of Biological Macromolecules, 2021, Vol.180, p. 272-285
Plasmodium falciparum expresses two essential cytosol localised chaperones; PfHsp70-1 and PfHsp70-z. PfHsp70-z (Hsp110 homologue) is thought to facilitate nucleotide exchange function of PfHsp70-1. PfHsp70-1 is a refoldase, [...]

Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein

Publication year: 2021
Authors: Sarcina L. 1, Mangiatordi G.F. 2, Torricelli F. 3, Bollella P. 1, Gounani Z. 4, Österbacka R. 4, Macchia E. 4, Torsi L. 1,4,5
Published in: Biosensors, 2021, Vol. 11(6), p. 180
The early detection of the human immunodeficiency virus (HIV) is of paramount importance to achieve efficient therapeutic treatment and limit the disease spreading. In this perspective, [...]

Mutation of GGMP Repeat Segments of Plasmodium falciparum Hsp70-1 Compromises Chaperone Function and Hop Co-Chaperone Binding

Publication year: 2021
Authors: S. Makumire 1,2 , T. Harmfree Dongola 1, G. Chakafana 1,3, L. Tshikonwane 1, C. Tshikani Chauke 1, T. Maharaj 4, T. Zininga 1,4, A. Shonhai 1
Published in: International Journal of Molecular Sciences, 2021, Vol. 22(4), p. 2226
Parasitic organisms especially those of the Apicomplexan phylum, harbour a cytosol localised canonical Hsp70 chaperone. One of the defining features of this protein is the presence of GGMP repeat residues [...]

Kinetic and thermodynamic insights into the interaction of Aβ1–42 with astaxanthin and aggregation behavior of Aβ1–42: Surface plasmon resonance, microscopic, and molecular docking studies

Publication year: 2021
Authors: Moharram Dehghani a, Razieh Jalal a,b, Mohammad-Reza Rashidi c
Published in: Biophysical Chemistry, 2021, Vol.275, p. 106612
Amyloid-β 1–42 (Aβ1–42) aggregation is considered as an important process in the pathology of Alzheimer's disease (AD). Astaxanthin (ATX), a xanthophyll carotenoid, has a broad range [...]

Membrane interactions of the anuran antimicrobial peptide HSP1-NH2: Different aspects of the association to anionic and zwitterionic biomimetic systems

Publication year: 2021
Authors: I.P.Gomes a, T.L.Santos a, Souza a., L.O.Nunes a, G.A.Cardoso a,b, C.O.Matos c, L.M.F.Costa a, L.M.Lião c, J.M.Resende b, R.M.Verly a
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021, Vol. 1863 (1), p. 183449
Studies have suggested that antimicrobial peptides act by different mechanisms, such as micellisation, self-assembly of nanostructures and pore formation on the membrane surface. This work presents [...]

Supporting data on characterisation of linker switch mutants of Plasmodium falciparum heat shock protein 110 and canonical Hsp70

Publication year: 2021
Authors: Graham Chakafana a,b, Pertunia T. Mudau a, Tawanda Zininga a,c, Addmore Shonhai a
Published in: Data in Brief, 2021, Vol. 37, p. 107177
Here, we present data on characterisation of the linker of Plasmodium falciparum Hsp110 (PfHsp70-z) relative to the linker of canonical Hsp70s in support of a co-published article [1]. The linker of PfHsp70-z was [...]

Adsorption and Conformation Behavior of Lysozyme on a Gold Surface Determined by QCM-D, MP-SPR, and FTIR

Publication year: 2021
Authors: Komorek P. 1, Martin E. 2, Jachimska B. 1
Published in: International Journal of Molecular Sciences, 2021, Vol. 22(3), p.1322
The physicochemical properties of protein layers at the solid–liquid interface are essential in many biological processes. This study aimed to link the structural analysis of adsorbed lysozyme [...]

Understanding the effects of different residual lignin fractions in acid-pretreated bamboo residues on its enzymatic digestibility

Publication year: 2021
Authors: Wenqian Lin 1, Jinlai Yang 2, Yayue Zheng 1, Caoxing Huang 1, Qiang Yong 1
Published in: Biotechnology for Biofuels, 2021, Vol. 14, Article number: 143 (2021)
During the dilute acid pretreatment process, the resulting pseudo-lignin and lignin droplets deposited on the surface of lignocellulose and inhibit the enzymatic digestibility of cellulose in lignocellulose. [...]

Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

Publication year: 2021
Authors: Kayamba F. a. Malimabe T. b,c, Ademola I.K. d, Pooe O.J. e, Kushwaha N.D. a, Mahlalela M. a, van Zyl R.L. b,c, Gordon M. d, Mudau P.T. f, Zininga T. f,g, Shonhai A. g, Nyamori V.O. h, Karpoormath R. a
Published in: European Journal of Medicinal Chemistry, 2021, Vol. 217, p. 113330
Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative [...]

Control of Polymer Brush Morphology, Rheology, and Protein Repulsion by Hydrogen Bond Complexation

Publication year: 2021
Authors: Andersson J. 1, Ferrand-Drake del Castillo G. 1, Bilotto P. 2, Höök F. 3, Valtiner M. 2, Dahlin A. 1
Published in: Langmuir, 2021, Vol. 37 (16), p. 4943–4952
Polymer brushes are widely used to alter the properties of interfaces. In particular, poly(ethylene glycol) (PEG) and similar polymers can make surfaces inert toward biomolecular adsorption. Neutral hydrophilic [...]

Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings

Publication year: 2021
Authors: Soeder E. 1,2, Garay-Saramiento S. 1,3, Rahimi K. 1, Obstals F. 1,2, Dedisch S. 1,3, Haraszti T. 1, Davari M.D. 3, Jakob F. 1,3, Hess C. 4, Schwaneberg U. 1,3, Rodriguez-Emmenegger C. 1
Published in: Macromolecular Bioscience, 2021, 2100158
The ability of proteins to adsorb irreversibly onto surfaces opens new possibilities to functionalize biological interfaces. Herein, the mechanism and kinetics of adsorption of protein-polymer macromolecules [...]

Bacterial surface, biofilm and virulence properties of Listeriamonocytogenes strains isolated from smoked salmon and fish food contact surfaces

Publication year: 2021
Authors: Sudagidan M. a, Ozalp V.C. b, Öztürk O. c, Zafer Yurt M.N, a, Yavuz O. d, Tasbasi B.B. a, Ucak S. e, Mavili Z.S., Coban A. g, Aydin A. h
Published in: Food Bioscience, 2021, Vol. 41, p.101021
Biofilm formation is one of the defense mechanisms of bacteria against disinfectants and antimicrobials. The aim of this study was to determine biofilm-forming L.monocytogenes from fish processing [...]

Rapid and Oriented Immobilization of Laccases on Electrodes via a Methionine-Rich Peptide

Publication year: 2021
Authors: Haiyang Cui a,b, Lingling Zhang a, Dominik Söder b, Xiaomei Tang a, Mehdi D. Davari a, Ulrich Schwaneberg a,b
Published in: ACS Catalysis, 2021, Vol. 11 (4), p. 2445–2453
Different from other laccases, copper efflux oxidase (CueO) from Escherichia coli possesses an additional methionine-rich segment (MetRich), which is generally considered to be detrimental to its oxidase activity. Herein, we reveal that [...]

Oxidized xylan additive for nanocellulose films – A swelling modifier

Publication year: 2021
Authors: Palasingh Ch. a, Ström A. a, Amer H. b,c, Nypelö T. a,d
Published in: International Journal of Biological Macromolecules, Vol. 180, p. 753-759
Polymeric wood hemicelluloses are depicted to join cellulose, starch and chitosan as key polysaccharides for sustainable materials engineering. However, the approaches to incorporate hemicelluloses in [...]