MP-SPR Navi™ instruments can be applied to research biomaterials of great variety, such as for example biocompatible hydrogels, drug-loaded functional materials, antifouling coating materials and biomembranes. MP-SPR technology allows for a thorough characterization of biomaterials, from the characterization of their thickness and refractive index, to the assessment of swelling and resistance to biofouling, and the determination of kinetic constants. Or in other words, MP-SPR allows you to conduct a complete study of your material all the way from characterizing interactions with proteins, serum and plasma up to interactions with bacteria and cells.
Applications for MP-SPR in biomaterial research:
- Layer-by-Layer deposition monitoring, from nanometers up to micrometer-thick coatings!
- Monitoring of stimuli-response polymers or nanoparticles
- Monitoring film deposition (in situ or ex situ)
- Calculation of interaction kinetics and surface coverage (mass per surface area)
- Gas permeation monitoring for barrier coatings
- Monitoring the formation of self-assembled layers or coatings (SAMs)
- Monitoring swelling and hydration
- Monitoring drug release from polymer matrices
- Selection of suitable surface model and surface characterization
- Interaction studies of biomaterials with specific proteins, serum and plasma, biomembranes, cells and bacteria
- Membrane stability and quality (thickness and optical density) assessment
- From measurements on biomembranes to measurements on live cells
Benefits of MP-SPR in soft materials research are:
- Measurements possible in wet and dry environment – water/solvent swelling does not interfere
- Measurements possible at different pH, temperature (15 to 45 °C), electric potential
- Thickness of polymers up to 5 µm
- Thickness and refractive index determined using LayerSolver™
- PureKinetics™, unique reduction of environmental artefacts
- On-line monitoring of nanofabrication (Layer-by-Layer)
- Easy lipid membrane formation on variety of substrates
- High sensitivity
- Combination of MP-SPR with electrochemistry
- Sensor recycling often possible (lower total cost of ownership)
- No oil, contamination-free continuation of experiments to AFM, XPS, etc.
- Prism not integrated to substrate – substrate can be used after MP-SPR measurement to measure AFM, XPS, etc.
- Easy handling of sensor slides for ex situ modification and measurements
- AN#171 Optical dispersion modelling of thin layers with multiwavelength MP-SPR
- AN#167 Capture of T-cells and analysis of membrane receptor affinity with biofunctionalized lipid sensor
- AN#165 Cellulose fiber-based yarn development for capturing estrogen residues from aqueous matrices with MP-SPR
- AN#163 Characterization of micrometer thick layers of spin-coated chitin
- AN#161 Polymerization kinetics and morphology changes of thermo-responsive polymer
- AN#159 Material swelling studies using MP-SPR: Cellulose in water vapor and polymer barrier in solvent vapors
- AN#158 Predicting cellulose nanocrystals dispersibility using MP-SPR
- AN#157 Detection of toxin induced pore formation in membranes
- AN#154 Real-time cancer cell detection and cell adhesion on implant materials surface
- AN#150 Organophosphonates characterization using MP-SPR
- AN#149 Polymer characterization using MP-SPR – Adsorption studies and layer thickness
- AN#139 Liposomes attachment on the sensor surface – thickness and refractive index ensure the layer conformation
- AN#137 Drug interaction with cell monolayer measured with MP-SPR
- AN#128 Thickness and refractive index of dielectric layers using multiple wavelengths or multiple media
Or brows our list of MP-SPR related peer-reviewed publications
