Application Note #137
MDCKII cell monolayer was deposited on a gold sensor slide. Drug interaction with the cell monolayer was measured in constant flow conditions.
Cell monolayer was deposited on a SPR sensor slide. Multi-Parametric Surface Plasmon Resonance (MP-SPR) was used to measure drugs (propranolol and D-mannitol) interaction with the cell monolayer in real time and in controlled flow conditions. It was possible to distinguish between paracellular and transcellular drug absorption routes.
Recommended instrument for this application
- If you are interested in living cell studies, you may also view AN#156 about nanoparticle uptake by living cells and AN#154 about cell adhesion on implant material surface and cancer cell detection.
- Do you want to see how MP-SPR instruments work? Click here
- Do you want to see comparison of MP-SPR instruments? Click here