Comparing QCM & MP-SPR: A flowrate study
Application Note #129
Liposomes interaction with streptavidin functionalized sensor surface at different flow rates. Figure displays normalized signal responses from both SPR and QCM measurements.
MP-SPR can be used to study the effect of hydrodynamic flow on the interaction kinetics, making it a valuable tool in biomolecular interaction and targeted drug delivery studies.
Blood stream hydrodynamics is known to be an important pharmacokinetic factor that varies in different vessels and organs throughout the body. Liposomes are used in drug delivery systems to carry drug molecules to the effective site with some products already on the market. Liposomes are also widely studied as drug delivery systems for new drug targeting applications.
Recommended instrument for this application
Further reading
- If you are interested in nanoparticle interaction studies, view AN#152 and AN#157, or if you are interested in biomolecular interactions, view AN#147 and AN#155.
- Do you want to see how MP-SPR instruments work? Click here
- Do you want to see MP-SPR instruments comparison? Click here
- See original publication for further information: Fluid dynamics modeling for synchronizing surface plasmon resonance and quartz crystal microbalance as tools for biomolecular and targeted drug delivery studies