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Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Publication year: 2018
Authors: Domínguez-Vega E. a, Haselberg R. a, van Iperen D. b, Kool J. a, Somsen G.W. a, de Jong G.J. c
Published in: Sensors and Actuators B: Chemical, 2018, Vol. 254, p. 1040-1047
Surface plasmon resonance (SPR) currently is the major platform to study protein–protein interactions, but it lacks the selectivity o distinguish between binding components within one sample. [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]

Advancing Peptide-Based Biorecognition Elements for Biosensors Using In-Silico Evolution

Publication year: 2018
Authors: Xiao X. 1, Kuang Z. 2, Slocik J.M. 2, Tadepalli S. 4, Brothers M. 3, Kim S. 3, Mirau P.A. 2, Butkus C. 2, Farmer B.L. 2, Singamaneni S. 4, Hall C.K. 1, Naik R.R. 3
Published in: ACS Sensors, 2018, Vol. 3, Issue 5, p. 1024–1031
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. [...]

Bovine serum albumin binding study to erlotinib using surface plasmon resonance and molecular docking methods

Publication year: 2018
Authors: Taghipour P. 1, Zakariazadeh M. 2, Sharifi M. 3, Ezzati Nazhad Dolatabadi J. 4, Barzegar A. 5
Published in: Journal of Photochemistry and Photobiology B, 2018, Vol. 183, p. 11-15
Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with erlotinib [...]

Target-triggering multiple-cycle signal amplification strategy for ultrasensitive detection of DNA based on QCM and SPR

Publication year: 2018
Authors: Song W. 1, Guo X. 1, Sun W. 2, Yin W. 1, He P. 1, Yang X. 1, Zhang X. 3
Published in: Analytical Biochemisry, 2018, p. 57-61
Detection of ultralow concentrations of nucleic acid sequences is a central challenge in the early diagnosis of genetic diseases. Herein, we developed a target-triggering cascade multiple cycle amplification for ultrasensitive DNA detection using [...]

Generation and validation of murine monoclonal and camelid recombinant single domain antibodies specific for human pancreatic glycoprotein 2

Publication year: 2018
Authors: Schlör A. a, Holzlöhner P. a, Listek M. a, Griess C. a, Butze M. a, Micheel B. a, Hentschel Ch. b, Sowa M. b, Roggenbuck D. b,c, Schierack P. c, Füner J. d, Schliebs E. d, Goihl A. e, Reinhold D. e, Hanack K. a
Published in: New Biotechnology, 2018
Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified as a major autoantigenic target in Crohn’s disease patients. It was reported recently that a long (GP2a) and a short (GP2b) isoform [...]

Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine

Publication year: 2018
Authors: Berninger T. a, Bliem C. a, Piccinini E. b, Azzaroni O. b, Knoll W. a
Published in: Biosensors and Bioelectronics, 2018, Vol. 115, p. 104-110
Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine. Arginase [...]

pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

Publication year: 2018
Authors: Barattin M. 1, Mattarei A. 2, Balasso A. 1, Paradisi C. 2, Cantù L. 3, Del Favero E. 3, Viitala T. 4, Mastrotto F. 1, Caliceti P. 1, Salmaso S. 1
Published in: ACS Applied Materials & Interfaces, 2018, Vol. 10 (21), p. 17646–17661
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposome decoration with a new novel synthetic non-peptidic [...]

Cyclopropylamine plasma polymer surfaces for label-free SPR and QCM immunosensing of Salmonella

Publication year: 2018
Authors: Makhneva E. a, b, Farka Z. c, Skladal P. c, d, Zajickova L. a,b
Published in: Sensors and Actuators B: Chemical, 2018
We report on the first successful application of nitrogen-containing functional surfaces prepared by plasma polymerization in surface plasmon resonance (SPR) immunosensing. The plasma polymers (PPs) [...]

Dynamic dispersal of surface layer biofilm induced by n-TiO2 based on surface plasmon resonance and waveguide

Publication year: 2018
Authors: Zhang P. 1,2, Guo J.S. 3, Yan P. 2, Chen Y.P. 4,2, Wang W. 5, Dai Y.Z. 1, Fang F. 2, Wang G.X. 6, Shen Y. 7
Published in: Applied and Environmental Microbiology, 2018
Pollutant degradation is mainly presented in the surface layer of biofilm, while the surface layer is the most vulnerable to the impairment of toxic pollutants. In this work, the effect of nanosized TiO2 [...]

Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements

Publication year: 2018
Authors: Parkkila P. 1, Elderfi M. 2, Bunker A. 1, Viitala T. 1
Published in: Langmuir, 2018, Vol. 34 (27), p. 8081-8091
Supported lipid bilayers (SLBs) have been used extensively as an effective model of biological membranes, in the context of in vitro biophysics research, and the membranes of liposomes, [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Publication year: 2018
Authors: Orelma H. 1, Virtanen T. 1, Spoljaric S. 2, Lehmonen J. 1, Seppälä J. 2, Rojas O.J. 3, Harlin A. 1
Published in: Biomacromolecules, 2018, Vol. 19 (2), p. 652–661
A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic [...]

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

Characterization of membrane–foulant interactions with novel combination of Raman spectroscopy, surface plasmon resonance and molecular dynamics simulation

Publication year: 2018
Authors: Virtanen T. a, Parkkila P. b, Koivuniemi A. b, Lahti J. a, Viitala T. b, Kallioinen M. a, Mänttäri M. a, Bunker A. b
Published in: Separation and Purification Technology, 2018, Vol. 5, p. 263-272
Adsorptive fouling, by phenolic compounds, is a serious issue regarding the development and use of membrane based filtration technologies for water [...]

Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Publication year: 2018
Authors: Costa R.R. 1,2, González-Pérez M. 3,4, Herrero-Gutiérrez M. 3,4, Pires R.A. 1,2,5, Alonso M. 3,4, Rodriguez-Cabello J.C. 3,4, Reis R.L. 1,2,5, Pashkuleva I. 1,2
Published in: Biomacromolecules, 2018, Vol. 19(8), p. 3401-3411
We introduce elastin-like recombinamers (ELRs) as polypeptides with precise amino acid positioning to generate polypeptide coatings with tunable rigidity. Two ELRs [...]