In vitro monitoring of drug release kinetics
with real-time MP-SPR

Application Note #141

Figure 1. A thin polymer was deposited on a sensor slide ex situ and small molecule weight drug release from the film was monitored in real-time with MP-SPR.

A real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument was used to monitor the release rate of a small molecular weight drug, Perphenazine, from 5 microns thin EUDRAGIT®-based polymer films. The release kinetics was clearly faster from a film containing a film thickening excipient, Polyvinyl-pyrrolidone (PVP) compared to a film without excipient. MP-SPR results had a good correlation with results of in vitro reference measurements. The MP-SPR experiments revealed additional kinetic information compared to traditional in vitro measurements.

Recommended instrument for this application:

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200 OTSO 400 KONTIO 210A VASA  410A KAURIS  220A NAALI 420A ILVES 
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