Comparing QCM and MP-SPR results. A flow-rate study.

Application Note #129

Langmuir-blodgett


Figure 2
. Liposomes interaction with streptavidin functionalized sensor surface at different flow rates. A) Normalized signal responses from both SPR and QCM measurements.

MP-SPR can be used to study the effect of hydrodynamic flow on the interaction kinetics, making it a valuable tool in biomolecular interaction and targeted drug delivery studies.

Blood stream hydrodynamics is known to be an important pharmacokinetic factor that varies in different vessels and organs throughout the body. Liposomes are used in drug delivery systems to carry drug molecules to the effective site with some products already on the market. Liposomes are also widely studied as drug delivery systems for new drug targeting applications.

Recommended instrument for this application:

200_otso_small.jpg 400_KONTIO_LOGO_24012019_cropped.jpg 210_vasa_small.jpg 410A_KAURIS_instrument.jpg  220A_naali_small.jpg 420_ilves_small.jpg
200 OTSO 400 KONTIO 210A VASA  410A KAURIS  220A NAALI 420A ILVES 
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Further reading

  • If you are interested in nanoparticle interaction studies, view AN#152
    and AN#157or if you are interested in biomolecular interactions,
    view AN#147 and AN#155.

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