Search publications 


Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Publication year: 2018
Authors: Orelma H. 1, Virtanen T. 1, Spoljaric S. 2, Lehmonen J. 1, Seppälä J. 2, Rojas O.J. 3, Harlin A. 1
Published in: Biomacromolecules, 2018, Vol. 19 (2), p. 652–661
A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic [...]

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

Characterization of membrane–foulant interactions with novel combination of Raman spectroscopy, surface plasmon resonance and molecular dynamics simulation

Publication year: 2018
Authors: Virtanen T. a, Parkkila P. b, Koivuniemi A. b, Lahti J. a, Viitala T. b, Kallioinen M. a, Mänttäri M. a, Bunker A. b
Published in: Separation and Purification Technology, 2018, Vol. 5, p. 263-272
Adsorptive fouling, by phenolic compounds, is a serious issue regarding the development and use of membrane based filtration technologies for water [...]

Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Publication year: 2018
Authors: Costa R.R. 1,2, González-Pérez M. 3,4, Herrero-Gutiérrez M. 3,4, Pires R.A. 1,2,5, Alonso M. 3,4, Rodriguez-Cabello J.C. 3,4, Reis R.L. 1,2,5, Pashkuleva I. 1,2
Published in: Biomacromolecules, 2018, Vol. 19(8), p. 3401-3411
We introduce elastin-like recombinamers (ELRs) as polypeptides with precise amino acid positioning to generate polypeptide coatings with tunable rigidity. Two ELRs [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Molecular Therapy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]

The Influence of PEG-Thiol Derivatives on Controlling Cellular and Bacterial Interactions with Gold Surfaces

Publication year: 2018
Authors: Al-Ani A., Boden A., Al Kobaisi M., Pingle H., Wang P.-Y., Kingshott P.
Published in: Applied Surface Science, 2018, Vol. 462, p. 980-990
Surface modification with hydrophilic polymers is used extensively in a range of biomedical applications in order to control the interactions with proteins, cells and bacteria. owever, the architecture of the polymer layers [...]

High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions

Publication year: 2018
Authors: Selin M. 1, Nummelin S. 2, Deleu J. 1,3, Ropponen J. 4, Viitala T. 5, Lahtinen M. 6, Koivisto J. 7, Hirvonen J. 1, Peltonen L. 1, Kostinainen M.A. 2,8, Bimbo L.M. 1,9
Published in: Biomacromolecules, 2018, Vol. 19 (10), p. 3983–3993
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Publication year: 2018
Authors: Lakayan D. 1,2, Haselberg R. 1, Gahoual R. 1,3, Somsen G.W. 1, Kool J. 4
Published in: Analytical and Bioanalytical Chemisry, 2018, p. 1-12
Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are highly potent biopharmaceuticals designed for targeted cancer therapies. mAbs and ADCs can undergo modifications during [...]

In operando measurements of kinetics of solid electrolyte interphase formation in lithium-ion batteries

Publication year: 2018
Authors: Alemu T. a, Pradanawati S.A. a,b, Chang S.-C. a, Lin P.-L. a, Kuo Y.-L. c, Pham Q.-T. a, Su C.-H. d, Wang F.-M. a,e
Published in: Journal of Power Sources, 2018, Vol. 400, p. 426-433
This study applied two in operando techniques to reveal the reaction kinetics of solid electrolyte interphase formation on electrolyte and benzimidazole salt additives. The results obtained from studying interface effects reveal [...]

Phase-segregated Membrane Model assessed by a combined SPR-AFM Approach

Publication year: 2018
Authors: Millone D.A.M. 1, Vázquez R.F. 1, Maté S.M. 2, Vela M.E. 3
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 172, p. 423-429
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides [...]

On the Importance of Controlling Film Architecture in Detecting Prostate Specific Antigen

Publication year: 2018
Authors: Graça J. S. a, Miyazaki C. M. a, Shimizu F. M. b, Volpati D. c, Mejía-Salazar J. R. b, Oliveira O.N. Jr. b, Ferreira M. a
Published in: Applied Surface Science, 2018, Vol. 434, p. 1175-1182
Immunosensors made with nanostructured films are promising for detecting cancer biomarkers, even at early stages of the disease, but this requires control of film architecture to preserve [...]

A DNA–nanoparticle actuator enabling optical monitoring of nanoscale movements induced by an electric field

Publication year: 2018
Authors: Tapio K. a, Shao D. a, Auer S. b, Tuppurainen J. c, Ahlskog M. a, Hytönen V.P. b, Toppari J.J. a*
Published in: Nanoscale, 2018, Vol. 10, p. 19297-19309
Merging biological and non-biological matter to fabricate nanoscale assemblies with controllable motion and function is of great interest due to its potential application, for example, in diagnostics and biosensing. [...]

Salt-Induced Control of the Grafting Density in Poly(ethylene glycol) Brush Layers by a Grafting-to Approach

Publication year: 2018
Authors: Ortiz R. 1, Olsen S. 2, Thormann E. 1
Published in: Langmuir, 2018, Vol. 34(15), p. 4455-4464
In this work, a method to obtain control of the grafting density during the formation of polymer brush layers by the grafting-to method of thiolated poly(ethylene glycol) onto gold is presented. The grafting density [...]