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Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Molecular Therapy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions

Publication year: 2018
Authors: Selin M. 1, Nummelin S. 2, Deleu J. 1,3, Ropponen J. 4, Viitala T. 5, Lahtinen M. 6, Koivisto J. 7, Hirvonen J. 1, Peltonen L. 1, Kostinainen M.A. 2,8, Bimbo L.M. 1,9
Published in: Biomacromolecules, 2018, Vol. 19 (10), p. 3983–3993
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Phase-segregated Membrane Model assessed by a combined SPR-AFM Approach

Publication year: 2018
Authors: Millone D.A.M. 1, Vázquez R.F. 1, Maté S.M. 2, Vela M.E. 3
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 172, p. 423-429
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]

Molecular Details of Retinal Guanylyl Cyclase 1/GCAP-2 Interaction

Publication year: 2018
Authors: Rehkamp A. 1, Tänzler D. 1, Iacobucci C. 1, Golbik R.P. 2, Ihling C.H. 1, Sinz A. 1
Published in: Frontiers in Molecular Neuroscience, 2018, Vol. 11
The rod outer segment guanylyl cyclase 1 (ROS-GC1) is an essential component of photo-transduction in the retina. In the light-induced signal cascade, membrane-bound ROS-GC1 restores cGMP levels [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Publication year: 2018
Authors: Lakayan D. 1,2, Haselberg R. 1, Gahoual R. 1,3, Somsen G.W. 1, Kool J. 4
Published in: Analytical and Bioanalytical Chemisry, 2018, p. 1-12
Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are highly potent biopharmaceuticals designed for targeted cancer therapies. mAbs and ADCs can undergo modifications during [...]

Oligomerization Alters Binding Affinity Between Amyloid Beta and a Modulator of Peptide Aggregation

Publication year: 2017
Authors: Hilt S. 1, Rojalin T. 2, 3, Viitala T. 3, Koivuniemi A.3, Bunker A. 3, Wachsmann-Hogiu S. 2, 4, Kálai T. 5, Hideg K. 5, Yliperttula M. 3, 6, Voss J. C. 1
Published in: The Journal of Physical Chemistry C, 2017, Vol. 121 (43), p. 23974–23987
The soluble oligomeric form of the amyloid beta (Aβ) peptide is the major causative agent in the molecular pathogenesis of Alzheimer’s disease (AD). We have previously developed a pyrroline-nitroxyl fluorene compound (SLF) that blocks [...]

Surface plasmon resonance biosensor for enzymatic detection of small analytes

Publication year: 2017
Authors: Miyazaki C.M., Shimizu F.M., Mejía-Salazar J.R., Oliveira O.N., Ferreira M.
Published in: Nanotechnology, 2017, Vol. 28(14), p. 145501
Surface plasmon resonance (SPR) biosensing is based on the detection of small changes in the refractive index on a gold surface modified with molecular recognition materials, thus being mostly limited to detecting large molecules. [...]

Improving the mechanical properties of CNF films by NMMO partial dissolution with hot calender activation

Publication year: 2017
Authors: Orelma H., Korpela A., Kunnari V., Harlin A., Suurnäkki A.
Published in: Cellulose 2017
Reinforcing of cellulose nanofibril (CNF) films by partial dissolution with N-methylmorpholine-N-oxide (NMMO) was investigated. The method investigated is composed of impregnation of CNF film [...]

Homogeneous cellulose thin films by regeneration of cellulose xanthate: properties and characterization

Publication year: 2017
Authors: Weißl M. 1, 2, Niegelhell K. 2, Reishofer D. 2, Zankel A. 3, Innerlohinger J. 4, Spirk S. 2
Published in: Cellulose, 2017, Vol. 25, Issue 1, p. 711-721
The preparation and characterization of cellulose thin films derived from cellulose xanthate is reported. The films are prepared by depositing alkaline aqueous solutions cellulose xanthate onto silicon wafers, followed by [...]

Early-stage detection of VE-cadherin during endothelial differentiation of human mesenchymal stem cells using SPR biosensor

Publication year: 2017
Authors: Fathi F. 1, Rezabakhsh A. 2, Rahbarghazi R. 3, Rashidi M.R. 4
Published in: Biosensors and Bioelectronics, 2017, Vol. 96, p. 358-366
Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time dynamic analysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the need for labeling processes. [...]

Dangerous liaisons: anion-induced protonation in phosphate-polyamine interactions and their implications for charge states of biologically relevant surfaces

Publication year: 2017
Authors: Laucirica G., Marmisollé W.A., Azzaroni O.
Published in: Physical Chemistry Chemical Physics, 2017, Vol. 19 (12), p. 8612-8620
Although not always considered a preponderant interaction, amine-phosphate interactions are omnipresent in multiple chemical and biological systems. [...]

Taste masking effect of chlorogenic acid (CGA) on bitter drugs evaluated by taste sensor and surface plasmon resonance on the basis of CGA-Drug interactions

Publication year: 2017
Authors: Shiraishi S.1, Haraguchi T., Nakamura S., Li D., Kojima H., Yoshida M., Uchida T.
Published in: Chemical and Pharmaceutical Bulletin, Vol. 65 (2017), No. 2, p. 127-13
The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. [...]