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Kinetic and thermodynamic studies of bovine serum albumin interaction with ascorbyl palmitate and ascorbyl stearate food additives using surface plasmon resonance

Publication year: 2018
Authors: Fathi F. a, Mohammadzadeh-Aghdash H. b, c, Sohrabi Y. b, c, Dehghan P. b, Ezzati J. N. D. a
Published in: Food Chemistry, 2018, Vol. 246, p.228-232
Ascorbyl palmitate (AP) and ascorbyl stearate (AS) are examples of food additives, which have extensive use in food industry. In this study, we evaluated the interaction of bovine serum albumin (BSA) with [...]

Characterization of membrane–foulant interactions with novel combination of Raman spectroscopy, surface plasmon resonance and molecular dynamics simulation

Publication year: 2018
Authors: Virtanen T. a, Parkkila P. b, Koivuniemi A. b, Lahti J. a, Viitala T. b, Kallioinen M. a, Mänttäri M. a, Bunker A. b
Published in: Separation and Purification Technology, 2018, Vol. 5, p. 263-272
Adsorptive fouling, by phenolic compounds, is a serious issue regarding the development and use of membrane based filtration technologies for water [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Publication year: 2018
Authors: Costa R.R. 1,2, González-Pérez M. 3,4, Herrero-Gutiérrez M. 3,4, Pires R.A. 1,2,5, Alonso M. 3,4, Rodriguez-Cabello J.C. 3,4, Reis R.L. 1,2,5, Pashkuleva I. 1,2
Published in: Biomacromolecules, 2018, Vol. 19(8), p. 3401-3411
We introduce elastin-like recombinamers (ELRs) as polypeptides with precise amino acid positioning to generate polypeptide coatings with tunable rigidity. Two ELRs [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]

Carboxyl-rich plasma polymer surfaces in surface plasmon resonance immunosensing

Publication year: 2018
Authors: Makhneva E. 1, 2, 6, Obrusnik A. 1, 2, 6, Farka Z. 3, Skladal P. 3, 4, Vandenbossche M. 5, Hegemann D. 5, Zajickova L. 1, 2
Published in: Japanese Journal of Applied Physics, 2018, Vol. 57, Number 1S, 01AG06
Stable carboxyl-rich plasma polymers (PPs) were deposited onto the gold surface of surface plasmon resonance (SPR) chips under conditions that were chosen based on lumped kinetic model results. Carboxyl-rich films are [...]

The Influence of PEG-Thiol Derivatives on Controlling Cellular and Bacterial Interactions with Gold Surfaces

Publication year: 2018
Authors: Al-Ani A., Boden A., Al Kobaisi M., Pingle H., Wang P.-Y., Kingshott P.
Published in: Applied Surface Science, 2018, Vol. 462, p. 980-990
Surface modification with hydrophilic polymers is used extensively in a range of biomedical applications in order to control the interactions with proteins, cells and bacteria. owever, the architecture of the polymer layers [...]

Surface Plasmon Resonance for Measuring Exocytosis from Populations of PC12 Cells: Mechanisms of Signal Formation and Assessment of Analytical Capabilities

Publication year: 2017
Authors: Moreira B. 1, Tuoriniemi J. 1, Kouchak Pour N. 1, Mihalčíková L.1, Safina G. 1,2
Published in: Analytical Chemistry, 2017, Vol. 89 (5), p. 3069–3077
Because of cell to cell variation, it is difficult to obtain statistically significant data on the frequency of exocytosis events (Rexocytosis, t–1 m–2) with traditional single cell electrophysiological [...]

Characterization of IFN-γ Detection and Electrochemical Proximity Assay by a Novel Multi-Parametric/Multimodal Spectroscopy Apparatus

Publication year: 2017
Authors: Zhou L., Chin B. A., Simonian A. L.*
Published in: ECS Transactions, 2017, Vol. 80, Issue 10, p. 1565-1570
Functional interfaces play a vital role in biosensing, which requires proper allocation, orientation, conformation, activities and stability to achieve high affinity and stability of the biomolecules. However, the characterization [...]

Effect of Lipoxygenase Oxidation on Surface Deposition of Unsaturated Fatty Acids

Publication year: 2017
Authors: Tayeb A.H.1, Hubbe M.A.1, Zhang Y. 2 , Rojas O.J. 1,3
Published in: Langmuir, 2017, Vol. 33 (18), p. 4559–4566
We studied the interactions of lipid molecules (linoleic acid, glycerol trilinoleate and a complex mixture of wood extractives) with hydrophilic and hydrophobic surfaces (cellulose nanofibrils (CNFs) [...]

Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer

Publication year: 2017
Authors: Soudy R. 1,2,5, Etayash H. 1, Bahadorani K.1, Lavasanifar A. 1,3, Kaur K. 1,4
Published in: Molecular Pharmaceutics, 2017, Vol. 14 (3), p. 593–604
The biomarkers or receptors expressed on cancer cells and the targeting ligands with high binding affinity for biomarkers play a key role in early detection and treatment of breast cancer. [...]

Characterization of Covalently Bound Anti-Human Immunoglobulins on Self-Assembled Monolayer Modified Gold Electrodes

Publication year: 2017
Authors: Holzer B. 1, Manoli K. 1, Ditaranto N. 1,2, Macchia E. 1, Tiwari A. 1, Di Franco C. 3, Scamarcio G. 3,4, Palazzo G. 1,2, Torsi L. 1,2
Published in: Advanced Biosystems, 2017
Bioconjugated gold surfaces constitute interesting platforms for biosensing applications. The immobilization of antibodies such as anti-immunoglobulin G and M (anti-IgG and anti-IgM) [...]

Quantitative interpretation of PAMAM dendrimers adsorption on silica surface

Publication year: 2017
Authors: Tokarczyk K., Jachimska B
Published in: Journal of Colloid and Interface Science, 2017 Vol. 503, p. 86-94
Understanding the dendrimer-solid support interaction is of great importance for dendrimer-based drug delivery system design. The maximum surface coverage on a hydrophilic silica surface was determined using [...]

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Publication year: 2017
Authors: Carney R.P. 1, Hazari S. 1, Rojalin T. 2,3, Knudson A. 1, Gao T. 3,4, Tang Y. 3,4, Liu R. 1, Viitala T. 5, Yliperttula M. 5,6, Lam K.S. 1,7
Published in: Advanced Biosystems, 2017, Vol. 1 (5), p. 1600038
All cells expel a variety of nanosized extracellular vesicles (EVs), including exosomes, with composition reflecting the cells' biological state. Cancer pathology is dramatically mediated by EV trafficking [...]

Graphene and graphene oxide for biosensing

Publication year: 2017
Authors: Kubesa O. 1, Horackova V. 2, Moravec Z. 2,3, Farka Z. 2, Skladal P. 1,2
Published in: Monatshefte für Chemie, 2017
Graphene-based nanomaterials attract large attention in electrochemistry due to their unique properties. Reliable method to modify electrodes by graphene is necessary to obtain desired improvement. In this work, [...]

Lignin Films from Spruce, Eucalyptus, and Wheat Straw Studied with Electroacoustic and Optical Sensors: Effect of Composition and Electrostatic Screening on Enzyme Binding

Publication year: 2017
Authors: Pereira A. 1,2, Hoeger I.C. 2, Ferrer A. 2 , Rencoret J. 1, del Rio J.C. 1, Kruus K. 3§, Rahikainen J. 3, Kellock M. 3, Gutiérrez A. 1, Rojas O.J. 2,4
Published in: Biomacromolecules, 2017, Vol. 18 (4), p. 1322–1332
Lignins were isolated from spruce, wheat straw, and eucalyptus by using the milled wood lignin (MWL) method. Functional groups and compositional analyses were assessed [...]

Detachment of Membrane Bound Virions by Competitive Ligand Binding Induced Receptor Depletion

Publication year: 2017
Authors: Parveen N. 1, Block S. 1, Zhdanov V.P. 1,2, Rydell G.E. 3, Höök F. 1
Published in: Langmuir, 2017, Vol. 33 (16), p. 4049–4056
Multivalent receptor-mediated interactions between virions and a lipid membrane can be weakened using competitive nonpathogenic ligand binding. In particular, the subsequent binding [...]

Ultrasensitive detection of nucleic acids and proteins using quartz crystal microbalance and surface plasmon resonance sensors based on target-triggering multiple signal amplification strategy

Publication year: 2017
Authors: Sun W. 1, Song W. 2, Guo X. 3, Wang Z. 1
Published in: Analytica Chimica Acta, 2017, Vol. 978, p. 42-47
In this study, quartz crystal microbalance (QCM) and surface plasmon resonance (SPR) sensors were combined with template enhanced hybridization processes (TEHP), rolling circle amplification (RCA) [...]

New Approach for Thickness Determination of Solution-Deposited Graphene Thin Films

Publication year: 2017
Authors: Jussila H. 1,2, Albrow-Owen T. 1, Yang H. 2, Hu G. 1, Aksimsek S. 2,3, Granqvist N. 4, Lipsanen H. 2, Howe R.C.T. 1, Sun Z. 2, Hasan T. 1
Published in: ACS Omega, 2017, Vol. 2 (6), p. 2630–2638
Solution processing-based fabrication techniques such as liquid phase exfoliation may enable economically feasible utilization of graphene and related nanomaterials in real-world devices in the near future. [...]

Angiogenic and Restorative Abilities of Human Mesenchymal Stem Cells Were Reduced Following Treatment With Serum From Diabetes Mellitus Type 2 Patients

Publication year: 2017
Authors: Rezaie J. 1, Mehranjani M.S. 1, Rahbarghazi R. 2,3, Shariatzadeh M.A. 1
Published in: Journal of Cellular Biochemistry, 2017, 9999, p. 1-12
This experiment investigated the impact of serum from patients with type 2 diabetes mellitus on the angiogenic behavior of human mesenchymal stem cells in vitro. Changes in the level [...]