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Multilayer Density Analysis of Cellulose Thin Films

Publication year: 2019
Authors: Sampl C. 1,2ʈ, Niegelhell K. 1,2ʈ, Reishofer D. 1ʈ, Resel R. 3ʈ, Spirk S. 1,2*ʈ, Hirn U. 1,2ʈ
Published in: Biopolymer Thin Films and Coatings
An approach for the multilayer density analysis of polysaccharicle thin films at the example of cellulose is presented. In detail, a model was developed for the evaluation of the density in different layers across the thickness direction of the film.[...]

Matter‐tag: A universal immobilization platform for enzymes on polymers, metals, and silicon‐based materials

Publication year: 2019
Authors: Sarah Dedisch 1,2 Annika Wiens 2 Mehdi D. Davari 2 Dominik Söder 1 Cesar Rodriguez‐Emmenegger 1,3 Felix Jakob 1,2 Ulrich Schwaneberg 1,2
Published in: Biotechnology and Bioengineerging
Enzyme immobilization is extensively studied to improve enzyme properties in catalysis and analytical applications. Here, we introduce a simple and versatile enzyme immobilization platform based on adhesion‐promoting peptides, namely Matter‐tags. [...]

Nanoparticles in Pharmacotheraphy Chapter 9B

Publication year: 2019
Authors: Barbara Jachimska
Published in: Elsevier
Physicochemical characterization of PAMAM dendrimer as a multifunctional nanocarriers

The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease

Publication year: 2019
Authors: Lee B.H. 1, Kim S.H. 1, Ko Y. 2, Park J.C. 3, Ji S. 4, Gu M.B. 5
Published in: Biosensors and Bioelectronics, 2019, Vol. 126, p. 122-128
This research aims to develop biosensors which could diagnose periodontal diseases in early phases and predict the illness stage of patients, in order to give them adequate treatment timely. [...]

Self-assembled hybrid nanocomposite films of carbon dots and hydrolyzed collagen

Publication year: 2019
Authors: Tarciane da S. Pinto a, Priscilla N.S. Rodrigues a, Luiz E.S. Marinho a, Rodrigo M. Verly a, J.P. Bretas Roa a, Luiz C.A. de Oliveira b, Fabiano V. Pereira b, Mariana T.Q. de Magalhães c,d, João P. de Mesquita a
Published in: Materials Chemistry and Physics, 2019, Vol. 230, p. 44-53
In the present work, hydrophilic carbon dots (CD) prepared by cotton cellulose were used in the building of self-assembled films with hydrolyzed collagen (CL) to verify their properties, especially molecular interactions and morphology. [...]

Affinity maturation and characterization of the ofatumumab monoclonal antibody

Publication year: 2018
Authors: Payandeh Z. 1, Rajabibazl M. 2,3, Mortazavi Y. 1,4, Rahimpour A. 3, Taromchi A.H. 1,4, Dastmalchi S. 5,6
Published in: Journal of Cellular Biochemistry, 2018
CD20 molecule, a phosphoprotein with 297 amino acids and four transmembrane domains, is a member of MS4A protein family. Anti-CD20 antibodies such as ofatumumab, which have been developed [...]

Label-free biosensors in the field of stem cell biology

Publication year: 2018
Authors: Fathi F. a, Rahbarghazi R. b, c, Rashidi M.-R. a, d
Published in: Biosensors and Bioelectronics, 2018, Vol. 101, p. 188-198
A great body of evidence unveiled the existence of different stem cell types in various tissues with efficient capability for self-renewal and differentiation. Characterization and enumeration [...]

Lectins at Interfaces—An Atomic Force Microscopy and Multi-Parameter-Surface Plasmon Resonance Study

Publication year: 2018
Authors: Niegelhell K. 1, Ganner T. 2, Plank H. 3, Jantscher-Krenn E. 4, Spirk S. 5
Published in: Materials 2018, Vol. 11(12), p. 2348
Lectins are a diverse class of carbohydrate binding proteins with pivotal roles in cell communication and signaling in many (patho)physiologic processes in the human body, making them promising [...]

Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects

Publication year: 2018
Authors: Koivusalo L. a, Karvinen J. e, Sorsa E. b, Jönkkäri I. c, Väliaho J. b, Kallio P. b, Ilmarinen T. a, Miettinen S. a, Skottman H. a, Kellomäki M. a, b
Published in: Materials Science and Engineering: C, Vol. 85, 2018, p. 68–78
Corneal blindness is a worldwide problem, plagued by insufficient amount of high-quality donor tissue. Cell therapy using human adipose stem cells (hASCs) has risen as an alternative [...]

Characterization of G4 PAMAM dendrimer complexes with 5-fluorouracil and their interactions with bovine serum albumin

Publication year: 2018
Authors: Tokarczyk K., Jachimska B.
Published in: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, Vol. 561, p. 357-363
The success of novel therapeutic strategies relies strongly on the development of a reliable active agent delivery mechanism. In this work, we address he question of how G4 PAMAM dendrimers [...]

Kinetic and thermodynamic studies of bovine serum albumin interaction with ascorbyl palmitate and ascorbyl stearate food additives using surface plasmon resonance

Publication year: 2018
Authors: Fathi F. a, Mohammadzadeh-Aghdash H. b, c, Sohrabi Y. b, c, Dehghan P. b, Ezzati J. N. D. a
Published in: Food Chemistry, 2018, Vol. 246, p.228-232
Ascorbyl palmitate (AP) and ascorbyl stearate (AS) are examples of food additives, which have extensive use in food industry. In this study, we evaluated the interaction of bovine serum albumin (BSA) with [...]

Interaction of lecithin-cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I derived peptides

Publication year: 2018
Authors: Casteleijn M. G., Parkkila P., Viitala T., Koivuniemi A.
Published in: Journal of Lipid Research, 2018
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme responsible for the formation of cholesteryl esters from unesterified cholesterol (UE) and phospholipid (PL) molecules in high-density lipoprotein (HDL) particles. [...]

Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Publication year: 2018
Authors: Magarkar A. a,b, Parkkila P. a, Viitala T. a, Lajunen T. a, Mobarak E. c,d, Licari G. e, Cramariuc O. c, Vauthey E. e , Rógc T. d, Bunker A.* a
Published in: Chemical Communications, 2018, Vol. 54, Issue 28, p. 3440-3443
The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms. Of these MB-COMT is a drug target [...]

Carboxyl-rich plasma polymer surfaces in surface plasmon resonance immunosensing

Publication year: 2018
Authors: Makhneva E. 1, 2, 6, Obrusnik A. 1, 2, 6, Farka Z. 3, Skladal P. 3, 4, Vandenbossche M. 5, Hegemann D. 5, Zajickova L. 1, 2
Published in: Japanese Journal of Applied Physics, 2018, Vol. 57, Number 1S, 01AG06
Stable carboxyl-rich plasma polymers (PPs) were deposited onto the gold surface of surface plasmon resonance (SPR) chips under conditions that were chosen based on lumped kinetic model results. Carboxyl-rich films are [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Publication year: 2018
Authors: Domínguez-Vega E. a, Haselberg R. a, van Iperen D. b, Kool J. a, Somsen G.W. a, de Jong G.J. c
Published in: Sensors and Actuators B: Chemical, 2018, Vol. 254, p. 1040-1047
Surface plasmon resonance (SPR) currently is the major platform to study protein–protein interactions, but it lacks the selectivity o distinguish between binding components within one sample. [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]

Advancing Peptide-Based Biorecognition Elements for Biosensors Using In-Silico Evolution

Publication year: 2018
Authors: Xiao X. 1, Kuang Z. 2, Slocik J.M. 2, Tadepalli S. 4, Brothers M. 3, Kim S. 3, Mirau P.A. 2, Butkus C. 2, Farmer B.L. 2, Singamaneni S. 4, Hall C.K. 1, Naik R.R. 3
Published in: ACS Sensors, 2018, Vol. 3, Issue 5, p. 1024–1031
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. [...]

Bovine serum albumin binding study to erlotinib using surface plasmon resonance and molecular docking methods

Publication year: 2018
Authors: Taghipour P. 1, Zakariazadeh M. 2, Sharifi M. 3, Ezzati Nazhad Dolatabadi J. 4, Barzegar A. 5
Published in: Journal of Photochemistry and Photobiology B, 2018, Vol. 183, p. 11-15
Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with erlotinib [...]

Target-triggering multiple-cycle signal amplification strategy for ultrasensitive detection of DNA based on QCM and SPR

Publication year: 2018
Authors: Song W. 1, Guo X. 1, Sun W. 2, Yin W. 1, He P. 1, Yang X. 1, Zhang X. 3
Published in: Analytical Biochemisry, 2018, p. 57-61
Detection of ultralow concentrations of nucleic acid sequences is a central challenge in the early diagnosis of genetic diseases. Herein, we developed a target-triggering cascade multiple cycle amplification for ultrasensitive DNA detection using [...]