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Real-Time Label-Free Targeting Assessment and in Vitro Characterization of Curcumin-Loaded Poly-lactic-co-glycolic Acid Nanoparticles for Oral Colon Targeting

Publication year: 2019
Authors: Mohamed A. Akl,†,‡ Alma Kartal-Hodzic,† Teemu Suutari,† Timo Oksanen,† Isabella Monia Montagner,§ Antonio Rosato,§,∥ Hatem R. Ismael,‡ Mohsen I. Afouna,‡ Paolo Caliceti,⊥ Marjo Yliperttula,†,⊥ Ahmed M. Samy,‡ Francesca Mastrotto,⊥ Stefano Salmaso,⊥ and Tapani Viitala*,†,#
Published in: ASC Omega
The exploitation of curcumin for oral disease treatment is limited by its low solubility, poor bioavailability, and low stability. Surface-functionalized poly-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) have shown promising results to ameliorate selective delivery of drugs to the gastrointestinal tract. [...]

Ch. 11: Optical and Acoustic Label-free Instrumentation for Molecular Detection with a Focus on Food

Publication year: 2019
Authors: J. Kuncová-Kallio, S. Auer, A. Spehar, H.H. Qu, D. Spasic, J. Lammertyn
Published in: Rapid Antibody-based technologies is Food Analysis, 2019, Vol. 15, p. 223-255
Food Chemistry, Function and Analysis: Optical and Acoustic Label-free Instrumentation for Molecular Detection with a Focus on Food

pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

Publication year: 2018
Authors: Barattin M. 1, Mattarei A. 2, Balasso A. 1, Paradisi C. 2, Cantù L. 3, Del Favero E. 3, Viitala T. 4, Mastrotto F. 1, Caliceti P. 1, Salmaso S. 1
Published in: ACS Applied Materials & Interfaces, 2018, Vol. 10 (21), p. 17646–17661
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposome decoration with a new novel synthetic non-peptidic [...]

Target-triggering multiple-cycle signal amplification strategy for ultrasensitive detection of DNA based on QCM and SPR

Publication year: 2018
Authors: Song W. 1, Guo X. 1, Sun W. 2, Yin W. 1, He P. 1, Yang X. 1, Zhang X. 3
Published in: Analytical Biochemisry, 2018, p. 57-61
Detection of ultralow concentrations of nucleic acid sequences is a central challenge in the early diagnosis of genetic diseases. Herein, we developed a target-triggering cascade multiple cycle amplification for ultrasensitive DNA detection using [...]

Quantitative Analysis of Thickness and pH Actuation of Weak Polyelectrolyte Brushes

Publication year: 2018
Authors: Ferrand-Drake del Castillo G., Emilsson G., Dahlin A.
Published in: The Journal of Physical Chemistry C, 2018, Issue 122 (48), p. 27516–27527
Polymer brushes are widely used as surface coatings for various inert, functional, or responsive interfaces. If the polymer can alter its protonation state (a polyelectrolyte (PE)), the brush can switch [...]

Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements

Publication year: 2018
Authors: Parkkila P. 1, Elderfi M. 2, Bunker A. 1, Viitala T. 1
Published in: Langmuir, 2018, Vol. 34 (27), p. 8081-8091
Supported lipid bilayers (SLBs) have been used extensively as an effective model of biological membranes, in the context of in vitro biophysics research, and the membranes of liposomes, [...]

Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine

Publication year: 2018
Authors: Berninger T. a, Bliem C. a, Piccinini E. b, Azzaroni O. b, Knoll W. a
Published in: Biosensors and Bioelectronics, 2018, Vol. 115, p. 104-110
Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine. Arginase [...]

Lectins at Interfaces—An Atomic Force Microscopy and Multi-Parameter-Surface Plasmon Resonance Study

Publication year: 2018
Authors: Niegelhell K. 1, Ganner T. 2, Plank H. 3, Jantscher-Krenn E. 4, Spirk S. 5
Published in: Materials 2018, Vol. 11(12), p. 2348
Lectins are a diverse class of carbohydrate binding proteins with pivotal roles in cell communication and signaling in many (patho)physiologic processes in the human body, making them promising [...]

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Cyclopropylamine plasma polymer surfaces for label-free SPR and QCM immunosensing of Salmonella

Publication year: 2018
Authors: Makhneva E. a, b, Farka Z. c, Skladal P. c, d, Zajickova L. a,b
Published in: Sensors and Actuators B: Chemical, 2018
We report on the first successful application of nitrogen-containing functional surfaces prepared by plasma polymerization in surface plasmon resonance (SPR) immunosensing. The plasma polymers (PPs) [...]

Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Molecular Therapy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions

Publication year: 2018
Authors: Selin M. 1, Nummelin S. 2, Deleu J. 1,3, Ropponen J. 4, Viitala T. 5, Lahtinen M. 6, Koivisto J. 7, Hirvonen J. 1, Peltonen L. 1, Kostinainen M.A. 2,8, Bimbo L.M. 1,9
Published in: Biomacromolecules, 2018, Vol. 19 (10), p. 3983–3993
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Phase-segregated Membrane Model assessed by a combined SPR-AFM Approach

Publication year: 2018
Authors: Millone D.A.M. 1, Vázquez R.F. 1, Maté S.M. 2, Vela M.E. 3
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 172, p. 423-429
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]