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Lubricin-Inspired Loop Zwitterionic Peptide for Fabrication of Superior Antifouling Surfaces

Publication year: 2021
Authors: Chuanxi Li 1,2, Yinqiang Xia 3, Chunjiang Liu 1, Renliang Huang 4, Wei Qi 1, Zhimin He 1, Rongxin Su 1,4
Published in: ACS Applied Materials & Interfaces, 2021, Vol. 13(35), p. 41978–41986
Biofouling represents great challenges in many applications, and zwitterionic peptides have been a promising candidate due to their biocompatibility and excellent antifouling performance. Inspired by lubricin, [...]

Membrane interactions of the anuran antimicrobial peptide HSP1-NH2: Different aspects of the association to anionic and zwitterionic biomimetic systems

Publication year: 2021
Authors: I.P.Gomes a, T.L.Santos a, A.N.de Souza a., L.O.Nunes a, G.A.Cardoso a,b, C.O.Matos c, L.M.F.Costa a, L.M.Lião c, J.M.Resende b, R.M.Verly a
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, 2021, Vol. 1863 (1), p. 183449
Studies have suggested that antimicrobial peptides act by different mechanisms, such as micellisation, self-assembly of nanostructures and pore formation on the membrane surface. This work presents [...]

Understanding the effects of different residual lignin fractions in acid-pretreated bamboo residues on its enzymatic digestibility

Publication year: 2021
Authors: Wenqian Lin 1, Jinlai Yang 2, Yayue Zheng 1, Caoxing Huang 1, Qiang Yong 1
Published in: Biotechnology for Biofuels, 2021, Vol. 14, Article number: 143 (2021)
During the dilute acid pretreatment process, the resulting pseudo-lignin and lignin droplets deposited on the surface of lignocellulose and inhibit the enzymatic digestibility of cellulose in lignocellulose. [...]

Adsorption and Conformation Behavior of Lysozyme on a Gold Surface Determined by QCM-D, MP-SPR, and FTIR

Publication year: 2021
Authors: Komorek P. 1, Martin E. 2, Jachimska B. 1
Published in: International Journal of Molecular Sciences, 2021, Vol. 22(3), p.1322
The physicochemical properties of protein layers at the solid–liquid interface are essential in many biological processes. This study aimed to link the structural analysis of adsorbed lysozyme [...]

Control of Polymer Brush Morphology, Rheology, and Protein Repulsion by Hydrogen Bond Complexation

Publication year: 2021
Authors: Andersson J. 1, Ferrand-Drake del Castillo G. 1, Bilotto P. 2, Höök F. 3, Valtiner M. 2, Dahlin A. 1
Published in: Langmuir, 2021, Vol. 37 (16), p. 4943–4952
Polymer brushes are widely used to alter the properties of interfaces. In particular, poly(ethylene glycol) (PEG) and similar polymers can make surfaces inert toward biomolecular adsorption. Neutral hydrophilic [...]

Design and synthesis of quinoline-pyrimidine inspired hybrids as potential plasmodial inhibitors

Publication year: 2021
Authors: Kayamba F. a. Malimabe T. b,c, Ademola I.K. d, Pooe O.J. e, Kushwaha N.D. a, Mahlalela M. a, van Zyl R.L. b,c, Gordon M. d, Mudau P.T. f, Zininga T. f,g, Shonhai A. g, Nyamori V.O. h, Karpoormath R. a
Published in: European Journal of Medicinal Chemistry, 2021, Vol. 217, p. 113330
Presently, artemisinin-based combination therapy (ACT) is the first-line therapy of Plasmodium falciparum malaria. With the emergence of malaria parasites that are resistant to ACT, alternative [...]

Unraveling the Mechanism and Kinetics of Binding of an LCI-eGFP-Polymer for Antifouling Coatings

Publication year: 2021
Authors: Soeder E. 1,2, Garay-Saramiento S. 1,3, Rahimi K. 1, Obstals F. 1,2, Dedisch S. 1,3, Haraszti T. 1, Davari M.D. 3, Jakob F. 1,3, Hess C. 4, Schwaneberg U. 1,3, Rodriguez-Emmenegger C. 1
Published in: Macromolecular Bioscience, 2021, 2100158
The ability of proteins to adsorb irreversibly onto surfaces opens new possibilities to functionalize biological interfaces. Herein, the mechanism and kinetics of adsorption of protein-polymer macromolecules [...]

One dimensional magneto-optical nanocomplex from silver nanoclusters and magnetite nanorods containing ordered mesocages for sensitive detection of PD-L1

Publication year: 2021
Authors: Xing Huang a,1 Zhao-huan Zhang b,1 Jie Chen a,c, Zhihui Mao a,d, Han Zhu a, Yawen Liu c,d,Zhongzheng Zhu e, Hongxia Chen a
Published in: Biosensors and Bioelectronics, 2021, Vol. 189, p. 113385
Programmed death ligand 1 (PD-L1) is a typical immune checkpoint protein, whose up-regulation on the membrane of different tumor cells inhibits the immune response f T cells and leads to the escape of tumor cells. [...]

Bacterial surface, biofilm and virulence properties of Listeriamonocytogenes strains isolated from smoked salmon and fish food contact surfaces

Publication year: 2021
Authors: Sudagidan M. a, Ozalp V.C. b, Öztürk O. c, Zafer Yurt M.N, a, Yavuz O. d, Tasbasi B.B. a, Ucak S. e, Mavili Z.S., Coban A. g, Aydin A. h
Published in: Food Bioscience, 2021, Vol. 41, p.101021
Biofilm formation is one of the defense mechanisms of bacteria against disinfectants and antimicrobials. The aim of this study was to determine biofilm-forming L.monocytogenes from fish processing [...]

A simple and direct SPR platform combining three-in-one multifunctional peptides for ultra-sensitive detection of PD-L1 exosomes

Publication year: 2021
Authors: Mao Z.a,b, Zhao J.c, Chen J.b,d, Hu X.b, Koh K.e, Chen H.b
Published in: Sensors and Actuators B: Chemical, 2021, Vol.346, p. 130496
Exosomes are lipid-bilayer-enclosed extracellular vehicles (EVs) derived from all cells and circulating in the blood. Identification of cancer specific exosomes in body fluids has shown great potential for [...]

Adhesion and Structural Changes of PEGylated Lipid Nanocarriers on Silica Surfaces

Publication year: 2021
Authors: Grad P. 1, Edwards K. 1, Hernández V.A. 2
Published in: Physchem, 2021, Vol. 1(2), p. 133-151
PEGylated lipid nanoparticles have a continuously expanding range of applications, particularly within pharmaceutical areas. Hereby, it is shown with the help of [...]

Rapid and Oriented Immobilization of Laccases on Electrodes via a Methionine-Rich Peptide

Publication year: 2021
Authors: Haiyang Cui a,b, Lingling Zhang a, Dominik Söder b, Xiaomei Tang a, Mehdi D. Davari a, Ulrich Schwaneberg a,b
Published in: ACS Catalysis, 2021, Vol. 11 (4), p. 2445–2453
Different from other laccases, copper efflux oxidase (CueO) from Escherichia coli possesses an additional methionine-rich segment (MetRich), which is generally considered to be detrimental to its oxidase activity. Herein, we reveal that [...]

Surface Plasmon Resonance Monitoring of Mono-Rhamnolipid Interaction with Phospholipid-Based Liposomes

Publication year: 2021
Authors: Belkilani M. 1,2.3, Shokouhi M. 4, Farre C. 1, Chevalier Y. 1, Minot S. 1, Bessueille F. 1, Abdelghani A. 3, Jaffrezic-Renault N. 1, Chaix C. 1
Published in: Langmuir, 2021, Vol. 37 (26), p. 7975–7985
The interactions of mono-rhamnolipids (mono-RLs) with model membranes were investigated through a biomimetic approach using phospholipid-based liposomes immobilized on a gold substrate [...]

Oxidized xylan additive for nanocellulose films – A swelling modifier

Publication year: 2021
Authors: Palasingh Ch. a, Ström A. a, Amer H. b,c, Nypelö T. a,d
Published in: International Journal of Biological Macromolecules, Vol. 180, p. 753-759
Polymeric wood hemicelluloses are depicted to join cellulose, starch and chitosan as key polysaccharides for sustainable materials engineering. However, the approaches to incorporate hemicelluloses in [...]

Surface Plasmon Resonance Assay for Label-Free and Selective Detection of Xylella Fastidiosa

Publication year: 2021
Authors: Sarcina L. 1, Macchia E. 2, Loconsole G. 3, D'Attoma G. 3, Saldarelli P. 3, Elicio V. 4, Palazzo G. 1, Torsi L. 1,2
Published in: Advanced NanoBiomed Research, 2021, p. 2100043
Xylella fastidiosa is among the most dangerous plant bacteria worldwide causing a variety of diseases, with huge economic impact on agriculture and environment. A surveillance tool, ensuring the highest possible sensitivity [...]

In-situ and real-time probing cellulase biosensor formation and its interaction with lignosulfonate in varied media

Publication year: 2021
Authors: Peipei Wang a,1, Tian Liu a,1, Yena Liu a,1, Jing Tian a, Xinyu Zhang a, Jiaqi Guo a, Yongcan Jin a, Huining Xiao b, Junlong Song a
Published in: Sensors and Actuators B: Chemical, Vol. 329 (2021), 129114
It is a challenge to interpret the signals obtained by Quartz Crystal Microbalance (QCM) and Surface Plasmon Resonance (SPR) accompanied with in the significant changes of the density and/or refractivity of media. [...]

Membrane interactions of Ocellatins. Where do antimicrobial gaps stem from?

Publication year: 2021
Authors: J.Muñoz‑López 1,2, J.C.L.Oliveira 1, D.A.G.R. Michel 3, C.S. Ferreira 3, F.Gomes Neto 4, E.S.Salnikov 2, R.M.Verly 3, B.Bechinger 2,5, J.M.Resende 1
Published in: Amino Acids, Vol. 53, p. 1241–1256 (2021)
The antimicrobial peptides Ocellatin-LB1, -LB2 and -F1, isolated from frogs, are identical from residue 1 to 22, which correspond to the -LB1 sequence, whereas -LB2 carries an extra N and -F1 additional NKL residues [...]

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein

Publication year: 2020
Authors: Hannestad J. a, Rocha S. b, Agnarsson B. a, Zhdanov V. ac, Wittung-Stafshede P. *b, Höök F. *a
Published in: Proceedings of National Academy of Sciences PNAS, 2020, Vol. 117, 25, p.14178-14186
The interaction of the neuronal protein α-synuclein with lipid membranes appears crucial in the context of Parkinson’s disease, but the underlying mechanistic details, including the roles of different lipids in pathogenic protein aggregation and membrane disruption, remain elusive. Here, we used single-vesicle resolution fluorescence and label-free scattering microscopy to investigate the interaction kinetics of monomeric α-synuclein with surface-tethered vesicles composed of different negatively charged lipids.[...]

Assessment of Gold Bio-Functionalization for Wide-Interface Biosensing Platforms

Publication year: 2020
Authors: Sarcina L. 1,Torsi L. 123, Picca R.A. 12, Manoli K. 12*, Macchia E. 3
Published in: Sensors, 2020, Vol. 20, p. 3678
The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses.[...]

Chitosan-Based Nanocomposites for Glyphosate Detection Using Surface Plasmon Resonance Sensor

Publication year: 2020
Authors: M.Huy Do 1,2, B.Dubreil 1, J.Peydecastaing 1, G.Vaca-Medina 1,3, T.-T.Nhu-Trang 4, N.Jaffrezic-Renault 5, P.Behra 1,2
Published in: Sensors 2020, Vol. 20(20), 5942
This article describes an optical method based on the association of surface plasmon resonance (SPR) with chitosan (CS) film and its nanocomposites, including zinc oxide (ZnO) or graphene oxide (GO) [...]