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Grafting hyaluronic acid onto gold surface to achieve low protein fouling in surface plasmon resonance biosensors

Publication year: 2014
Authors: Liu X., Huang R., Su R., Qi W., Wang L., He Z.
Published in: ACS Applied Materials and Interfaces, 2014, Vol. 6(15), p. 13034-42
Antifouling surfaces capable of reducing nonspecific protein adsorption from natural complex media are highly desirable in surface plasmon resonance (SPR) biosensors. A new protein-resistant surface [...]

Affibody conjugation onto bacterial cellulose tubes and bioseparation of human serum albumin

Publication year: 2014
Authors: Hannes Orelma,*a Luis O. Morales,a Leena-Sisko Johansson,a Ingrid C. Hoeger,b Ilari Filpponen,a Cristina Castro,c Orlando J. Rojasab and Janne Lainea
Published in: RSC Adv., 2014,4, p. 51440-51450
We attached anti-human serum albumin (anti-HSA) affibody ligands on bacterial cellulose (BC) by EDC–NHS-mediated covalent conjugation and physical adsorption and demonstrate their application for tubular biofiltration of blood proteins. [...]

Modification of surfaces with adsorption of amphiphilic polymers

Publication year: 2014
Authors: Katri Kontturi
Published in: Doctoral Dissertation
In this work the adsorption of amphiphilic polymers and their utilization in the modification of planar surfaces were examined. The approach was to systematically explore adsorption of very different types of [...]

Investigation of pH-Induced Protein Conformation Changes by Nanomechanical Deflection

Publication year: 2014
Authors: Thakur G. †, Jiang K. †, Lee D. †, Prashanthi K. †, Kim S. †‡, Thundat T. †
Published in: Langmuir, 2014, Vol. 30 (8), p. 2109–2116
Broad-spectrum biosensing technologies examine sensor signals using biomarkers, such as proteins, DNA, antibodies, specific cells, and macromolecules, based on direct- or indirect-conformational changes. [...]

Using gelatin protein to facilitate paper thermoformability

Publication year: 2014
Authors: A. Khakalo a, I. Filpponen a, L.S. Johansson a, A. Vishtal b, A.R. Lokanathan a,O. J. Rojas a,c, J. Laine a
Published in: Reactive & Functional Polymers, 2014
One of the main challenges of fiber-based packaging materials is the relatively poor elongation of cellulose under stress, which limits formability and molding in related products. [...]

Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection

Publication year: 2014
Authors: Islam N. †, Gurgel P.V. †, Rojas O.J. †‡, Carbonell R.G. †§
Published in: Journal of Physical Chemistry, 2014, Vol. 118 (10), p. 5361–5373
Alkanethiols carrying ethylene glycol units (EGn, n = 3 or 6) with amine termini (EG3NH2 or EG6NH2) were coadsorbed with a “diluent”, hydroxyl-terminated alkanethiol (EG3OH), to form mixed self-assembled monolayers (SAMs). The mixed SAMs were characterized, and hexameric peptide ligand His-Trp-Arg-Gly-Trp-Val (HWRGWV), which shows affinity binding toward the Fc (constant fragment) of human immunoglobulin (IgG), was grafted onto different dilutions of EG6NH2–EG3OH mixed SAMs for preparation of IgG detection surfaces. [...]

Biodegradable Polyurethane Carrying Antifoulants for Inhibition of Marine Biofouling

Publication year: 2014
Authors: Jielin Ma †, Chunfeng Ma *†, Yun Yang †, Wentao Xu †, and Guangzhao Zhang *†‡
Published in: Industrial & Engineering Chemistry Research, 2014, 53 (32), p. 12753–12759
Biodegradable polyurethane with N-(2,4,6-trichlorophenyl)maleimide (TCPM) pendant groups has been prepared via a combination of a thiol–ene click reaction and a condensation reaction. [...]

An impedimetric study of DNA hybridization on paper-supported inkjet-printed gold electrodes

Publication year: 2014
Authors: Ihalainen P. 1, Pettersson F. 2, Pesonen M. 2, Viitala T. 3, Määttänen A.1, Österbacka R. 2, Peltonen J. 1
Published in: Nanotechnology, 2014, Vol. 25, Issue 9
In this study, two different supramolecular recognition architectures for impedimetric detection of DNA hybridization have been formed on disposable paper-supported inkjet-printed gold electrodes. The gold electrodes were fabricated using a gold nanoparticle based ink. The first recognition architecture consists of subsequent layers of biotinylated self-assembly monolayer (SAM), streptavidin and biotinylated DNA probe. [...]

Tuning Cellulose Nanocrystal Gelation with Polysaccharides and Surfactants

Publication year: 2014
Authors: Zhen Hu, Emily D. Cranston, Robin Ng, and Robert Pelton*
Published in: Langmuir, 2014, 30 (10), pp 2684–2692
Gelation of cellulose nanocrystal (CNC) dispersions was measured as a function of the presence of four nonionic polysaccharides. Addition of hydroxyethyl cellulose (HEC), hydroxypropyl guar (HPG), or locust bean gum (LBG) to CNC dispersions [...]

Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance

Publication year: 2014
Authors: Islam N. 1, Shen F. 1, Gurgel P.V. 1, Rojas O.J. 2, Carbonell R.G. 3
Published in: Biosensors and Bioelectronics, Vol. 58, 2014, p. 380-387
This paper characterizes the potential of novel hexameric peptide ligands for on-line IgG detection in bioprocesses. Surface Plasmon Resonance (SPR) was used to study the binding of human IgG to the hexameric peptide ligand HWRGWV, which was covalently grafted to alkanethiol self-assembled monolayers (SAM) on gold surfaces. [...]

Surface modification of cellulose nanocrystals with cetyltrimethylammonium bromide

Publication year: 2014
Authors: Tiffany Abitbol, Heera Marway and, Emily D. Cranston Tiffany Abitbol (tiffany.abitbol@mail.mcgill.ca), Heera Marway (marwayhs@mcmaster.ca), Emily D. Cranston (ecranst@mcmaster.ca)
Published in: Special Issue: NANOCELLULOSE; Nordic Pulp & Paper Research Journal Vol 29 no (1) 2014
Cellulose nanocrystals (CNCs) prepared by sulfuric acid hydrolysis of cotton were surface modified with cetyltrimethylammonium bromide (CTAB). Essentially, the counterions of the CNC surface sulfate ester groups are exchanged for cetyltrimethyl-ammonium (CTA+), which acts as a bulky, amphiphilic cation. [...]

Surface Plasmon Resonance in Living Cell Sensing

Publication year: 2014
Authors: Teemu Suutari
Published in: Master's Thesis
Surface plasmon resonance (SPR) is a label free technique to study surface interactions. It is based on photon-plasmon coupling. Laser light is directed through a prism and reflects form a metal surface, often gold. At certain conditions, photons turn into plasmons, which then propagate [...]

Effect of gold nanoparticles on the structure and electron-transfer characteristics of glucose oxidase redox polyelectrolyte-surfactant complexes

Publication year: 2014
Authors: Cortez M.L. a,b, Marmisollé W. a, Pallarola D. b, Pietrasanta L.I. c, Murgida D.H. a, Ceolín M. b, Azzaroni O. b, Battaglini F. a
Published in: Chemistry A European Journal, 2014, Vol. 20, Issue 41, p. 13037–13404
Efficient electrical communication between redox proteins and electrodes is a critical issue in the operation and development of amperometric biosensors. The present study explores the advantages of a nanostructured redox-active polyelectrolyte-surfactant complex containing [Os(bpy)2Clpy](2+) (bpy=2,2'-bipyridine, py= pyridine) as the redox centers and gold nanoparticles (AuNPs) as nanodomains for boosting the electron-transfer propagation throughout the assembled film in the presence of glucose oxidase (GOx). [...]

Photoresponsive cellulose fibers by surface modification with multifunctional cellulose derivatives

Publication year: 2014
Authors: Olga Grigoray (a), Holger Wondraczek(a), Elina Heikkilä(a), Pedro Fardim (a,b,∗), Thomas Heinze (a,c)
Published in: Carbohydrate Polymers 111 (2014) 280–287
Eucalyptus bleached kraft pulp fibers were modified by adsorption of novel bio-based multifunctionalcellulose derivatives in order to generate light responsive surfaces. [...]

Modification of Cellulose Nanofibrils with Luminescent Carbon Dots

Publication year: 2014
Authors: Junkka K. 1, Guo J. 1, Filpponen I. 1, Lainen J. 1, Rojas O.J. 1,2
Published in: Biomacromolecules, 2014, Vol. 15 (3), p. 876–881
Films and hydrogels consisting of cellulose nanofibrils (CNF) were modified by covalent EDC/NHS coupling of luminescent, water-dispersible carbon dots (CDs). [...]

Marine Biofouling Resistance of Polyurethane with Biodegradation and Hydrolyzation

Publication year: 2014
Authors: Wentao Xu,† Chunfeng Ma,*,† Jielin Ma,† Tiansheng Gan,† and Guangzhao Zhang*,†,‡
Published in: ACS Applied Materials & Interfaces, 2014
We have prepared polyurethane with poly(ε-caprolactone) (PCL) as the segments of the main chain and poly(triisopropylsilyl acrylate) (PTIPSA) as the side chains by a combination of radical polymerization and a condensation reaction. [...]

Rapid and sensitive detection of maize chlorotic mottle virus using surface plasmon resonance-based biosensor

Publication year: 2013
Authors: Chang Zeng (a), Xin Huang (a), Jiangmin Xu (a), Guifen Li (a), Jie Ma (a), Hai-Feng Ji (b), Shuifang Zhu (a), Hongjun Chen (a)
Published in: Analytical Biochemistry, Vol. 440 (2013), p. 18–22
We report a biosensor based on surface plasmon resonance (SPR) for the selective detection of maizechlorotic mottle virus (MCMV). [...]

Non-labelled surface sensitive techniques as platforms for pharmaceutical nanotechnology research

Publication year: 2013
Authors: Huamin Liang, 2013
Published in: Doctor's Dissertation (article-based)
Insufficient delivery of drugs to the target sites like tumors and cells has been a barrier for achieving satisfying therapeutic effects in many diseases. Distribution and exposure of drugs to normal and healthy tissues may enhance the possibility of side effects and toxicity in vivo. Nanoparticle (NP) drug delivery systems have been developed to enable targeting of drugs to target sites and at the same time also reduce or even eliminate the distribution and exposure of drugs to non-targeted sites (normal and healthy tissues). The interactions of ligand attached NPs with specific receptors on the cell surface enable intracellular delivery of drugs. [...]

Specific water uptake of thin films from nanofibrillar cellulose

Publication year: 2013
Authors: Katri S. Kontturi (a), Eero Kontturi (a), Janne Laine (a)
Published in: J.Mater. Chem. A, 2013
Swelling of NFC films was surveyed by quartz crystal microbalance with dissipation monitoring coupled with H2O/D2O exchange and surface plasmon resonance. The influence of charged groups on swelling was investigated by neutralizing the charge of NFC with cationic polyelectrolytes or increasing the charge with carboxymethyl cellulose (CMC). [...]

Elucidating the Signal Responses of Multi-Parametric Surface Plasmon Resonance Living Cell Sensing: A Comparison between Optical Modeling and Drug–MDCKII Cell Interaction Measurements

Publication year: 2013
Authors: Tapani Viitala 1, Niko Granqvist 1, Susanna Hallila 1, Marjo Yliperttula 1, Manuela Raviña 2
Published in: PLoS ONE, 2013, Vol. 8(8), e72192
In vitro cell-based assays are widely used during the drug discovery and development process to test the biological activity of new drugs. Most of the commonly used cell-based assays, however, lack the ability to measure in real-time or under dynamic conditions (e.g. constant flow). In this study a multi-parameter surface plasmon resonance approach in combination with living cell sensing has been utilized for monitoring drug-cell interactions in real-time, under constant flow and without labels. [...]