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Phenylboronic-Acid-Based Polymeric Micelles for Mucoadhesive Anterior Segment Ocular Drug Delivery

Publication year: 2016
Authors: Prosperi-Porta G. 1, Kedzior S. 2, Muirhead B. 1, Sheardown H. 1,2
Published in: Biomacromolecules, 2016, Vol. 17(4), p. 1449-57
Topical drug delivery to the front of the eye is extremely inefficient due to effective natural protection mechanisms such as precorneal tear turnover and the relative impermeability of the cornea and sclera tissues. This causes low ocular drug bioavailability, requiring large frequent doses that result in high systemic exposure and side effects.[...]

Dopamine-assisted deposition and zwitteration of hyaluronic acid for the nanoscale fabrication of low-fouling surfaces

Publication year: 2016
Authors: Huijun Ye b, Yinqiang Xia b, Zhiqiang Liu b, Renliang Huang *a, Rongxin Su *b,c,d, Wei Qi b,c,d, Libing Wang *e, Zhimin He b
Published in: Journal of Materials Chemistry B, 2016, Vol. 4, p. 4084-4091
In this study, we proposed a bioinspired approach for the deposition and zwitteration of hyaluronic acid (HA) with a reduced glutathione (GSH) to form a composite layer that functions as a low fouling coating. [...]

Lignocellulosic Materials and their Interactions with Proteins and Surface Active Molecules

Publication year: 2016
Authors: Fritz C.
Published in: Doctoral dissertation, North Carolina State University
Lignocellulosic biomass is a highly valuable resource for the development of value-added biobased chemicals and other materials. However, the efficient utilization of this biomass regards on understanding the different interactions [...]

Toxin-induced pore formation is hindered by intermolecular hydrogen bonding in sphingomyelin bilayers

Publication year: 2016
Authors: Sara García-Linares a, b, Juan Palacios-Ortega a,b, Tomokazu Yasuda b,c, Mia Åstrand b, José G. Gavilanes a, Álvaro Martínez-del-Pozo a, J. Peter Slotte b
Published in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1858, Issue 6, p. 1189–1195
Sticholysin I and II (StnI and StnII) are pore-forming toxins that use sphingomyelin (SM) for membrane binding. We examined how hydrogen bonding among membrane SMs affected the StnI- and StnII-induced pore formation process, resulting in bilayer permeabilization. [...]

Enzymatic Precipitation Enhanced Surface Plasmon Resonance Immunosensor for the Detection of Salmonella in Powdered Milk

Publication year: 2016
Authors: Farka Z. 1, Juřík T. 1, 2, Pastucha M. 1, 2, Skládal P.1, 2
Published in: Analytical Chemistry, 2016, Vol. 88 (23), p. 11830–11836
Contamination of food by pathogenic bacteria has always been a serious threat for human health. The amount of food exports and imports has been increasing in recent years which requires precise food quality control [...]

Cellulose nanocrystal interactions probed by thin film swelling to predict dispersibility

Publication year: 2016
Authors: Reid M.S. a, Villalobos M. b, Cranston E.D. *a
Published in: Nanoscale, 2016, Vol. 8, p. 12247-12257
The production of well-dispersed reinforced polymer nanocomposites has been limited due to poor understanding of the interactions between components. Measuring the cohesive particle–particle interactions and the adhesive particle–polymer interactions is challenging due to nanoscale dimensions and poor colloidal stability of nanoparticles in many solvents. [...]

Regulation of Sticholysin II-Induced Pore Formation by Lipid Bilayer Composition, Phase State, and Interfacial Properties

Publication year: 2016
Authors: Palacios-Ortega J. 1,2, García-Linares S. 1,2, Åstrand M. 2, Al Sazzad M.A. 2, Gavilanes J.G. 1, Martínez-Del-Pozo Á. 1, Slotte J.P. 2
Published in: Langmuir, 2016, 32(14), p. 3476-84
Sticholysin II (StnII) is a pore-forming toxin that uses sphingomyelin (SM) as the recognition molecule in targeting membranes. After StnII monomers bind to SM, several toxin monomers act in concert to oligomerize into a functional pore. [...]

SPR Biosensing MUA/Poly-L-lysine Platform for the Detection of 2,4-Dinitrophenol as Small Molecule Model System

Publication year: 2016
Authors: Millone M.A.D. 1, Ramirez E.A. 1, Chain C.Y. 1, Crivaro A. 2, Romanin D. 2, Rumbo M. 2, Docena G. 2, Cocco M.D. 3, Pedano M.L. 3, Fainstein A. 3, Montoya J. 4, Vela M.E. 1, Salvarezza R.C. 1
Published in: Journal of Nanomaterials, Vol. 2016, Article ID 5432656, 9 p.
Surface Plasmon Resonance assays are being developed as alternative biodetection methods for a great number of pesticides and toxins. These substances typically have low molecular weight, [...]

Assembly of citrate gold nanoparticles on hydrophilic monolayers

Publication year: 2016
Authors: Vikholm-Lundin I. a, b, Rosqvist E. c, Ihalainen P. c, Munter T. d, Honkimaa A. e, Marjomäki V. f, Albers W.M. g, Peltonen J. c
Published in: Applied Surface Science, 2016, Vol. 378, p. 519–529
Self-assembled monolayers (SAMs) as model surfaces were linked onto planar gold films thorough lipoic acid or disulfide groups. The molecules used were polyethylene glycol (EG-S-S), N-[tris-(hydroxymethyl)methyl]acrylamide polymers with and without lipoic acid (Lipa-pTHMMAA and pTHMMAA) and a lipoic acid triazine derivative (Lipa-MF). [...]

On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples

Publication year: 2016
Authors: Dina Lakayan a, b, Rob Haselberg a, Wilfried M.A. Niessen a, c, Govert W. Somsen a, Jeroen Kool a
Published in: Journal of Chromatography A, Vol. 1452, p. 81–88
Surface plasmon resonance (SPR) is an optical technique that measures biomolecular interactions. Stand-alone SPR cannot distinguish different binding components present in one sample. Moreover, sample matrix components may show non-specific binding to the sensor surface [...]

Incorporation of gold nanoparticles into Langmuir-Blodgett films of polyaniline and montmorillonite for enhanced detection of metallic ions

Publication year: 2016
Authors: A. De Barros a, b, C.J.L. Constantino c, J.R.R. Bortoleto d, N.C. Da Cruz d, M. Ferreira b
Published in: Sensors and Actuators B: Chemical, Vol. 236, 2016, p. 408–417
We report on effects from incorporating gold nanoparticles (AuNPs) into Langmuir-Blodgett (LB) films of emeraldine salt polyaniline (PAni-ES) and organophilic montmorillonite clay (OMt). [...]

Noncovalent functionalization of solid-state nanopores via self-assembly of amphipols

Publication year: 2016
Authors: Pérez-Mitta G. 1, Burr L. 2, Tuninetti J.S. 1, Trautmann C. 2, Toimil-Molares M.E. 3, Azzaroni O. 4
Published in: Nanoscale, 2016, Vol. 8(3), p. 1470-8
In recent years there has been increasing interest in the development of new methods for conferring functional features to nanopore-based fluidic devices. In this work, we describe for the first time the noncovalent integration of amphoteric-amphipathic polymers, also known as "amphipols", into single conical nanopores in order to obtain signal-responsive chemical nanodevices. [...]

Immunological boosting and personalization of oncolytic virotherapies for cancer treatment

Publication year: 2016
Authors: Mari Hirvinen
Published in: Doctoral Dissertation
Cancer is the leading cause of death worldwide creating a need for novel cancer treatments that are more efficient but also safer and more specific. Oncolytic viruses (OVs) have shown a solid safety profile in clinical trials. OVs are nowadays considered immunotherapies because of to their ability to stimulate the host immune system to fight against cancer. [...]

HRP-Mimicking DNAzyme-Catalyzed in Situ Generation of Polyaniline To Assist Signal Amplification for Ultrasensitive Surface Plasmon Resonance Biosensing

Publication year: 2016
Authors: Haiyin Li, Jiafu Chang, Ting Hou, Feng Li
Published in: Analytical Chemistry, 2017, Vol. 89 (1), p. 673–680
It is well-known that the horseradish peroxidase- (HRP-) mimicking DNAzyme, namely, hemin/G-quadruplex, can effectively catalyze the polymerization of aniline to form DNA-guided polyaniline. [...]

Control of Protein Affinity of Bioactive Nanocellulose and Passivation Using Engineered Block and Random Copolymers

Publication year: 2016
Authors: Vuoriluoto M. 1, Orelma H. 1, Zhu B. 2, Johansson L.S. 1, Rojas O.J. 1
Published in: ACS Applied Materials & Interfaces, 2016, 2;8 (8), p: 5668-78
We passivated TEMPO-oxidized cellulose nanofibrils (TOCNF) toward human immunoglobulin G (hIgG) by modification with block and random copolymers of poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA). [...]

Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

Publication year: 2016
Authors: Otto K. Kari 1, Tatu Rojalin 2, Stefano Salmaso 3, Michela Barattin 4, Hanna Jarva 5, Seppo Meri 6, Marjo Yliperttula 7, Tapani Viitala 8, Arto Urtti 9
Published in: Drug Delivery and Translational Research, p. 1-13
When nanocarriers are administered into the blood circulation, a complex biomolecular layer known as the “protein corona” associates with their surface. Although the drivers of corona formation are not known, it is widely accepted that this layer mediates biological interactions of the nanocarrier with its surroundings. [...]

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

Publication year: 2016
Authors: Habib Baghirov 1,2,3,4, Didem Karaman 2,5, Tapani Viitala 6, Alain Duchanoy 2, Yan-Ru Lou 6, Veronika Mamaeva 1, Evgeny Pryazhnikov 7, Leonard Khiroug 7, Catharina de Lange Davies 4, Cecilia Sahlgren 1,3,8, Jessica M. Rosenholm 2,5
Published in: PLoS ONE 11(8): e0160705
Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesoporous silica nanoparticles (MSNs), [...]

Cationic and anionic polyelectrolyte complexes of xylan and chitosan. Interaction with lignocellulosic surfaces

Publication year: 2016
Authors: Mocchiutti P. 1, Schnell C.N. 2, Rossi G.D. 3, Peresin M.S. 4, Zanuttini M.A. 5, Galván M.V. 6
Published in: Carbohydrate Polymers, Vol. 150, p.89-98
Cationic (CatPECs) and anionic (AnPECs) polyelectrolyte complexes from xylan and chitosan were formed, characterized and adsorbed onto unbleached fibers for improving the papermaking properties.They were prepared [...]

Surfaces Mimicking Glycosaminoglycans Trigger Different Response of Stem Cells via Distinct Fibronectin Adsorption and Reorganization

Publication year: 2016
Authors: Araújo A.R. 1,2, Soares da Costa D. 1,2, Amorim S. 1.2, Reis R.L. 1,2, Pires R.A. 1,2 Pashkuleva I. 1,2
Published in: ACS Applied Materials & Interfaces, 2016, Vol. 8 (42), p. 28428–28436
We report on the utility of a platform created by self-assembled monolayers to investigate the influence of the degree of sulfation of glycosaminoglycans (GAGs) on their interactions with fibronectin (Fn) and the impact [...]

Combining Surface Plasmon Resonance and Quartz Crystal Microbalance To Determine Hydration of Dendrimer Monolayers

Publication year: 2016
Authors: Barbara Jachimska and Karolina Tokarczyk
Published in: Journal of Physical Chemistry C
Polyelectrolytes are abundant in nature and crucial due to their versatility in biological systems. The controlled assembly of polyelectrolytes has potential applications in the formation of nanostructured and microstructured materials of desired structure and functionality. [...]