Computer-Aided Engineering of Staphylokinase Toward Enhanced Affinity and Selectivity for Plasmin
Publication year: 2022
Authors: Nikitin D. 1 2, Mican J. 1 2 3, Toul M. 1 2, Bednar D. 1 2, Peskova M. 4 5, Kittova P. 4 6, Thalerova S. 1 4 5, Vitecek J. 1 4 3, Damborsky J. 1 2, Mikulik R. 1 3, Fleishman S. 7, Prokop Z. 1 2, Marek M. 1 2
Published in: Computational and Structural Biotechnology Journal, 2022, Vol. 20 p. 1366-1377
Cardio- and cerebrovascular diseases are leading causes of death and disability, resulting in one of the highest socio-economic burdens of any disease type. The discovery of bacterial and human plasminogen activators and their use as thrombolytic drugs have revolutionized treatment of these pathologies. Fibrin-specific agents have an advantage over non-specific factors because of lower rates…