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MP-SPR keyword: exosomes

Peer-reviewed publications

Rapid and sensitive detection of PD-L1 exosomes using Cu-TCPP 2D MOF as a SPR sensitizer

Publication year: 2022
Authors: Wang Y. a, Mao Z. b, Chen Q. c, Koh K. d, Hu X. a **, Chen H. a *
Published in: Biosensors and Bioelectronics, 201, 113954

Two-dimensional metal organic framework (2D MOF Cu-TCPP) with significantly enhanced photoelectric properties was synthesized by a simple hydrothermal method. The π-stacked electroactive porphyrin molecules of TCPP-based 2D MOF carry out charge transport in the MOF structure. The d-d band transition of Cu2+ and its 2D ultra-thin characteristics can produce excellent near-infrared light absorption to couple with SPR. Three key parameters including the refractive index sensitivity, detection…

Peer-reviewed publications

A simple and direct SPR platform combining three-in-one multifunctional peptides for ultra-sensitive detection of PD-L1 exosomes

Publication year: 2021
Authors: Mao Z.a,b, Zhao J.c, Chen J.b,d, Hu X.b, Koh K.e, Chen H.b
Published in: Sensors and Actuators B: Chemical, 2021, Vol.346, p. 130496

Exosomes are lipid-bilayer-enclosed extracellular vehicles (EVs) derived from all cells and circulating in the blood. Identification of cancer specific exosomes in body fluids has shown great potential for cancer diagnostics. The low concentration in blood and likely to deplete their native character on the solid surface makes it difficult to measure it in real time…

Peer-reviewed publications

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Publication year: 2017
Authors: Carney R.P. 1, Hazari S. 1, Rojalin T. 2,3, Knudson A. 1, Gao T. 3,4, Tang Y. 3,4, Liu R. 1, Viitala T. 5, Yliperttula M. 5,6, Lam K.S. 1,7
Published in: Advanced Biosystems, 2017, Vol. 1 (5), p. 1600038

All cells expel a variety of nanosized extracellular vesicles (EVs), including exosomes, with composition reflecting the cells’ biological state. Cancer pathology is dramatically mediated by EV trafficking via key proteins, lipids, metabolites, and microRNAs. Recent proteomics evidence suggests that tumor-associated exosomes exhibit distinct expression of certain membrane proteins, rendering those proteins as attractive targets for…