Different Oligomeric States of the Tumor Suppressor p53 Show Identical Binding Behavior Towards the S100beta Homodimer
Publication year: 2022
Authors: Wei A. 1, Iacobucci C. 1, Schultze W. 1, Ihling C. 1, Arlt C. 1, Sinz A. 1
Published in: ChemBioChem, 2022, Vol. 23, e202100665
The tumor suppressor protein p53 is a transcription factor that is referred to as the “guardian of the genome” and plays an important role in cancer development. P53 is active as a homotetramer; the S100β homodimer binds to the intrinsically disordered C-terminus of p53 affecting its transcriptional activity. The p53/S100β complex is regarded as highly…