Why choose MP-SPR for drug delivery studies?

Size does not matter

Nanoparticle binding causes large response in SPR measurements. That typically poses an issue for traditional SPR as its "measurement window" (also called "angular range") is limited to ten degrees. Traditional SPR instruments are built with a single wavelength which also limits their applicability. 

Uniquely, MP-SPR scans across almost forty degrees of angle and simultaneously records at two wavelengths. Therefore, MP-SPR can detect even large shifts in SPR peak. 

From targeting to internalization

Novel biopharmaceuticals perform better. Unfortunately, they typically do not enter the cell very easily. Therefore, nanocarriers are employed to improve internalization. MP-SPR is the only platform that allows you to start with nanoparticle-target interactions and follow with nanoparticle-lipid membranes and even all the way to nanoparticle internalization by living cells. 

Aggregating nanoparticles? Just try MP-SPR!

If you have once tried to measure nanoparticles on other instruments, you may have faced an expensive service call afterwards to exchange microfluidic flow-cell or tubings that were clogged by nanoparticles.

MP-SPR instruments are built in a way that allows the exchange of fluidics (including the flow-cell) by the user. Moreover, if you have an application resulting in deposition or aggregation of nanoparticles, you can select a flow-cell with larger inlet and outlet diameters that prevent clogging of the instrument.

From static to dynamic 

Most likely, you already have images of your nanoparticles before and after interaction using AFM, SEM, TEM or Raman. Now it is time to find out what happens in between. MP-SPR shows the affinity and kinetics of nanoparticle adsorption in dependance on their surface properties and environmental effects (e.g. pH, temperature, electric potential, light excitation). No sputtering, no vacuum. 

From SEM to SPR and back to SEM

Since our MP-SPR instruments use advanced elastomeric coating on a prism, we can use simple coated glass slides as measurement substrates. This allows the substrates to be repeatedly removed from the instrument for ex-situ modification or measurements. Therefore, the nanoparticles can be still characterized with microscopy techniques before and after the interaction, while MP-SPR is used to obtain information about the dynamics of the process.  

Let us help you find the right nanoparticle for the job!


Recommended MP-SPR instruments for drug delivery:

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