Controlled drug release formulations are extensively studied to enhance or extend drug absorption. MP-SPR enables in vitro comparison of drug release formulations.
See key questions about controlled drug release that MP-SPR can answer:
Figure 1. A thin polymer was deposited on a sensor slide ex situ and small molecule weight drug release from the film was monitored in real-time with MP-SPR.
A real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument was used to monitor the release rate of a small molecular weight drug, Perphenazine, from 5 microns thin EUDRAGIT®-based polymer films. The release kinetics was clearly faster from a film containing a film thickening excipient, Polyvinyl-pyrrolidone (PVP) compared to a film without excipient. MP-SPR results had a good correlation with results of in vitro reference measurements. The MP-SPR experiments revealed additional kinetic information compared to traditional in vitro measurements.
![]() |
![]() |
![]() |
![]() |