MP-SPR for controlled drug release

Controlled drug release formulations are extensively studied to enhance or extend drug absorption. MP-SPR enables in vitro comparison of drug release formulations.

See reasons to choose MP-SPR for controlled drug release studies:

Drug release from up to micron thick samples
Real-time and label-free measurements
Get rid of bulk effect
Understanding of structural changes

See key questions about controlled drug release that MP-SPR can answer:

What is the release rate of drug X from material Y?

See selected Application Notes to see that MP-SPR works:

AN#141 Small molecule weight drug release from various polymer films

Selected publications on controlled drug release:

Monitoring of drug release kinetics from thin polymer films by multi-parametric surface plasmon resonance, Korhonen et al., International Journal of Pharmaceutics, 2015, 494(1): p.531-536
Interaction studies between indomethacin nanocrystals and PEO/PPO copolymer stabilizers, Liu et al., Pharmaceutical Research, 2015

In vitro monitoring of drug release kinetics
with real-time MP-SPR

Application Note #141

Figure 1. A thin polymer was deposited on a sensor slide ex situ and small molecule weight drug release from the film was monitored in real-time with MP-SPR.

A real-time Multi-Parametric Surface Plasmon Resonance (MP-SPR) instrument was used to monitor the release rate of a small molecular weight drug, Perphenazine, from 5 microns thin EUDRAGIT®-based polymer films. The release kinetics was clearly faster from a film containing a film thickening excipient, Polyvinyl-pyrrolidone (PVP) compared to a film without excipient. MP-SPR results had a good correlation with results of in vitro reference measurements. The MP-SPR experiments revealed additional kinetic information compared to traditional in vitro measurements.