Welcome to the experts in Surface Plasmon Resonance

We aim to assist you on your way to absolute and high-quality results may they be in life sciences, biosensors or material sciences. Here we provide an executive summary about the MP-SPR technology, applications and products. More comprehensive information is available in our full website.

Applications of MP-SPR

Multi-Parametric Surface Plasmon Resonance (MP-SPR) is a real-time label-free surface sensitive technique that measures molecular interactions as well as structural changes and layer properties in both dry and wet state.

There are three major application areas of MP-SPR:

LIFE SCIENCES

Drug development (Drug formulation, Controlled drug release, Drug-cell interaction, Nanoparticle targeting, Uptake mechanisms)

Biophysics (Lipid interactions)

LIFE SCIENCES:
Why MP-SPR?

  • Unparalleled range: Optimize targeting from small molecule weight drugs up to nanoparticles and viruses
  • Beyond affinity: Evaluate affinity as well as kinetics of the molecular binding events to provide decision tools for further selection
  • Understanding: Understand better your molecules with kinetics and dynamic conformation change information from MP-SPR
  • PureKinetics™: Bulk effect measured in-line ensuring premium quality data even with small molecules, lipids or biomaterials.
  • Measurements from first selection of molecules up to uptake mechanisms:  Quantify drug-material, drug-target, drug-lipid membranes and even drug-living cell monolayer interactions. Prove internalization label-free!
  • Optimize formulation: determine drug release kinetic from film
  • No oil, no costly prism sensors: MP-SPR Navi™ instruments utilize optical refractive index matching elastomer. Therefore, sensors are very easy to exchange and to further analyze with other methods such as microscopy.     

BioNavis Ltd is the first one to introduce:

  • The only SPR to provide absolute measurement of interaction kinetics as well as layer structural changes.
  • First SPR instrument to distinguish trans- and para-cellular drug/nanoparticle transport on cell monolayer in real-time and label-free!
  • The first SPR with an in-line bulk effect measurement (PureKinetics™)
Life Science examplesPublications (in English)




BIOSENSORS

Assay development (Agriculture, Food and feed safety, Environmental, Clinical, Border and Process control).

Development of point-of-care biosensors (EC, SERS, ELISA, fluorescence, printed biosensors, nanoparticles)

BIOSENSORS:
Why MP-SPR?

  • No costly assay transfer: develop your sensor directly on your sensing material: metals for electrochemical (EC)  and SPR detection, plastics for ELISA, cellulose for printed biosensors, metal nanoparticles for SERS, glass for classical chemistry, magnetic nanoparticles, bacteria, living cells and more
  • Any assay type: using direct binding, competitive assays, antibodies, fragments, DNA, molecularly imprinted polymers (MIPs), aptamers, nanoparticles, cells
  • Any sample: Works with both gas and liquid samples, purified or crude, from small organic molecules up to metallic nanoparticles
  • Easy validation: In-situ MP-SPR with electrochemistry, fluorescence, or other optical detection methods. Ex-situ: Microscopy.
  • Beyond assay: Optimize also sample interaction with the disposable cartridge material to ensure binding only in the sensing area and not in the microfluidic channels.
  • Understanding: Not just measurements, but unparalleled understanding of your assay kinetics and structural changes.

BioNavis Ltd is the first one to introduce:

  • The only commercial SPR providing absolute measurement.
  • The widest range of sensing substrate materials in the market.
  • The first SPR with an in-line bulk effect measurement (PureKinetics™)
  • The first SPR to determine thickness and refractive index simultaneously (LayerSolver™)

Biosensors examplesPublications (in English)

 

MATERIAL SCIENCES

New materials and coatings (Antimicrobial,  Antireflective surfaces, Filter membranes, Contact lenses, Implants, Graphene, Carbon nanotubes, Green materials, Plasmonic materials,..)

Process optimization of thin film manufacturing 
(Display technologies, Solar cells, Batteries etc.)

MATERIAL SCIENCES:
Why MP-SPR?

  • Material freedom: Characterize nanolayers of metals, ceramics, polymers, organic materials and even nanocellulose or graphene
  • Nanolayers from Å to µm: Measure and quantify materials from the single layer up to micron-thick multilayers
  • Nanoparticles: Optimize nanoparticles and their adsorption kinetics
  • LayerSolver™: Quantify both key parameters - thickness and refractive index - simultaneously
  • Separate the best from better: The most sensitive measurement for kinetics on surfaces – real-time kinetics of adsorption, swelling, release.
  • From dry to wet state with same configuration
  • Easy validation: In-situ MP-SPR with electrochemistry, fluorescence, or other. Ex-situ: Thanks to oil-free operation, same sample can be measured with AFM or other techniques. In-silico: Results can be confirmed also analytically.
  • In-situ and Ex-situ modification of sensors: Our wide range of substrates can be modified with almost any thin film deposition technique including self-assembly, Langmuir-Blodgett (LB), Chemical Vapour Deposition (CVD), Evaporation, Atomic Layer Deposition (ALD), Molecular imprinting, Spin coating, Dip coating and others.

BioNavis Ltd is the first one to introduce:

  • First commercial SPR for material sciences
  • The most sensitive instrument to study biochemical properties of functional coatings.
  • The only instrument to measure alternating nanolaminate thickness from 5Å, optical density and its barrier functionality.
  • The first SPR to determine thickness and refractive index simultaneously (LayerSolver™)

Material Sciences examplesPublications (in English)


 

About BioNavis Ltd


We are the only manufacturer of MP-SPR instruments for studies of surface interactions and nanolayer characterization. We believe in:

  • Understanding rather than just measuring and that is why absolute results obtained with MP-SPR can be tracked down also analytically
  • Versatility rather than one-trick instruments and that is why our instruments can be used also in your future projects and those of your neighboring labs
  • Co-operation to advance science and translation of research results to industry

BioNavis Ltd is a privately held company based in Tampere, Finland.

More information

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