Hybrid POSS-Containing Brush on Gold Surfaces for Protein Resistance

Publication year: 2013
Authors: Xiaolu Ye (a), Junbo Gong (b), Zhongping Wang (b), Zengming Zhang (b), Sheng Han (c), Xuesong Jiang (a)*

(a) School of Chemistry and Chemical Engineering, State KeyLaboratory for Metal Matrix Composite Materials, Shanghai JiaoTong University, Shanghai 200240
(b) The Center for Physical Experiments and Department of Physics, School of Physics Science, University of Science and Technology of China, Hefei 230026, China
(c) Shanghai Institute of Technology, Shanghai 200235, China

Published in: Macromol. Biosci. 2013, 13, 921–926
doi: DOI: 10.1002/mabi.201200461

A hybrid polymer brush containing poly(ethylene glycol) (PEG) chains and polyhedraloligosilsesquioxane (POSS) on a gold surface is presented that exhibits an excellent protein resistance and long-term stability. A series of hybrid polymer brushes with different length and numbers of PEG chains are fabricated through chemisorption of PEG-POSS-SH on the gold surface. Protein adsorption of these hybrid brushes is investigated. The amount of protein adsorption decreases with increasing lengths and numbers of PEG chains. After immersion in BSA solution for two months, the PPS4 brushes retain their protein resistance, while a PEG-SH layer loses its non-fouling performance. These POSS-containing hybrid polymer brushes might offer an alternative for modification of gold surface with an excellent protein resistance for long-term applications.

MP-SPR keywords: adsorption, gold surface, PEG, polymer, protein resistance