Publications: Biosensors


A highly specific and sensitive nanoimmunosensor for the diagnosis of neuromyelitis optica spectrum disorders

Publication year: 2019
Authors: Ariana de Souza Moraes 1,2,3, Doralina Guimarães Brum3,4, Jéssica Cristiane Magalhães Ierich 1,2,3, Akemi Martins Higa1,2,3, Amanda Stefanie Jabur Assis2,3, Celina Massumi Miyazaki2, Flávio Makoto Shimizu5, Luís Antonio Peroni 6, M. Teresa Machini7, Amilton Antunes Barreira8,9, Marystela Ferreira 2, Osvaldo N. Oliveira Jr.5 & Fabio Lima Leite2,3
Published in: Scientific Reports
A precise diagnosis for neuromyelitis optica spectrum disorders (NMOSD) is crucial to improve patients’ prognostic, which requires highly specific and sensitive tests. The cell-based assay with a sensitivity of 76% and specificity of 100% is the most recommended test to detect anti-aquaporin-4 antibodies (AQP4-Ab). [...]

The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease

Publication year: 2019
Authors: Lee B.H. 1, Kim S.H. 1, Ko Y. 2, Park J.C. 3, Ji S. 4, Gu M.B. 5
Published in: Biosensors and Bioelectronics, 2019, Vol. 126, p. 122-128
This research aims to develop biosensors which could diagnose periodontal diseases in early phases and predict the illness stage of patients, in order to give them adequate treatment timely. [...]

Analytical Model To Describe the Effect of Polyethylene Glycol on Ionic Screening of Analyte Charges in Transistor-Based Immunosensing

Publication year: 2019
Authors: Haustein N., Gutierrez-Sanz O., Tarasov. A
Published in: ACS Sensors, 2019, Vol. 4, Issue 4, p. 874-882
Recently, the co-immobilization of polyethylene glycol has improved sensor responses of transistor-based immunosensing by approximately three times. However, there is currently [...]

Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes

Publication year: 2019
Authors: Ierich J.C.M. 1,2, Brum D.G. 3, Moraes A.S. 1,2, Higa A.M. 1,2, Garcia P.S. 1,2, Miyazaki C.M. 4, Ferreira M. 4, Peroni L.A. 5, Oliveira G.S. 6, Franca E.F. 6, Freitas L.C.G. 7, Leite F.L. 8
Published in: Scientific Reports, 2019, Vol. 9, Issue 1, p. 2033
Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential [...]

Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures

Publication year: 2019
Authors: Islam N. a,b, Gurgel P.V. a,c, Rojas O.J. a,d, Carbonell R.G. a,e
Published in: Bioconjugate Chemistry, 2019, Vol. 30, p. 815−825
Tris(2-aminoethyl)-amine (TREN), a branched amine, was coupled to planar surfaces of alkanethiol self-assembled monolayers (SAMs) to increase [...]

Maleic anhydride and acetylene plasma copolymer surfaces for SPR immunosensing

Publication year: 2019
Authors: Makhneva E. 1,2, Farka Z. 3, Pastucha M. 4,5, Obrusník A. 1,2, Horáčková V. 4, Skládal P. 4,5, Zajíčková L. 1,2
Published in: Analytical and Bioanalytical Chemisry, 2019
We report on the successful application of carboxyl-rich plasma polymerized (PP) films as a matrix layer for bioreceptor immobilization in surface plasmon resonance (SPR) immunosensing. Composition and [...]

Handbook of MP-SPR

Publication year: 2019
Authors: Marquart A., Kuncová-Kallio J., Albers M., Bombera R., Ståhlberg R.
Published in: Handbook of MP-SPR, 2019, Vol. 1, Based on fifth edition of Arnoud Marquart's Surface Plasmon Resonance book
Handbook of Multi-Parametric Surface Plasmon Resonance for Molecular Interaction Analysis - Theory and Practice

Ch. 11: Optical and Acoustic Label-free Instrumentation for Molecular Detection with a Focus on Food

Publication year: 2019
Authors: J. Kuncová-Kallio, S. Auer, A. Spehar, H.H. Qu, D. Spasic, J. Lammertyn
Published in: Rapid Antibody-based technologies is Food Analysis, 2019, Vol. 15, p. 223-255
Food Chemistry, Function and Analysis: Optical and Acoustic Label-free Instrumentation for Molecular Detection with a Focus on Food

Refractive Index and Sensing of Glucose Molarities Determined using Au-Cr K-SPR at 670/785 nm Wavelenght

Publication year: 2019
Authors: P. Susthitha Menon*, Budi Mulyanti, Nur Akmar Jamil, Chandra Wulandari, Harbi Setyo Nugroho, Gan Siew Mei, Noor Faizah Zainul Abidin, Lilik Hasanah, Roer Eka Pawinanto & Dilla Duryha Berhanuddin
Published in: Sains Malaysiana 48(6)(2019): 1259–1265

Trypanosoma cruzi Virulence Factors for the Diagnosis of Chagas’ Disease

Publication year: 2019
Authors: Cecilia Yamil Chain,*,† Dênio Emanuel Pires Souto,*,‡ María Laura Sbaraglini,§ Carlos A. Labriola,∥ María Antonieta Daza Millone,† Eduardo Alejandro Ramirez,† José Sebastián Cisneros,† Constanza Lopez-Albizu,⊥ Karenina Scollo,⊥ Lauro T. Kubota,# Andrés Mariano Ruiz,⊥ and María Elena Vela†
Published in: ACS Infectious Diseases
trans-Sialidase and cruzipain are important virulence factors from Trypanosoma cruzi, the etiological agent of Chagas disease, that have highly antigenic domains in their structure and were reported as potential tools for diagnosis of the illness. [...]

Label-free lateral flow assay for Listeria monocytogenes by aptamer-gated release of signal molecules

Publication year: 2019
Authors: Tasbasi BB 1, Guner BC 1, Sudagidan M 1, Ucak S 2, Kavruk M3, Ozalp VC 4.
Published in: Analytical Biochemistry
Lateral flow assay (LFA) type of biosensors have been popular due to cost-effectiveness and easy-interpretation for instant results, most common examples of applications being pregnancy tests, food safety or medical diagnostics. There are several examples of reports with high sensitivity, including pre-concentration of the sample by magnetic pull-down. However, sensitivity and direct detection designs with aptamers has been a limiting factor for developing aptamers-based LFA assays. [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Publication year: 2018
Authors: Lakayan D. 1,2, Haselberg R. 1, Gahoual R. 1,3, Somsen G.W. 1, Kool J. 4
Published in: Analytical and Bioanalytical Chemisry, 2018, p. 1-12
Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are highly potent biopharmaceuticals designed for targeted cancer therapies. mAbs and ADCs can undergo modifications during [...]

On the Importance of Controlling Film Architecture in Detecting Prostate Specific Antigen

Publication year: 2018
Authors: Graça J. S. a, Miyazaki C. M. a, Shimizu F. M. b, Volpati D. c, Mejía-Salazar J. R. b, Oliveira O.N. Jr. b, Ferreira M. a
Published in: Applied Surface Science, 2018, Vol. 434, p. 1175-1182
Immunosensors made with nanostructured films are promising for detecting cancer biomarkers, even at early stages of the disease, but this requires control of film architecture to preserve [...]