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Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

Publication year: 2016
Authors: Habib Baghirov 1,2,3,4, Didem Karaman 2,5, Tapani Viitala 6, Alain Duchanoy 2, Yan-Ru Lou 6, Veronika Mamaeva 1, Evgeny Pryazhnikov 7, Leonard Khiroug 7, Catharina de Lange Davies 4, Cecilia Sahlgren 1,3,8, Jessica M. Rosenholm 2,5
Published in: PLoS ONE 11(8): e0160705
Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesoporous silica nanoparticles (MSNs), [...]

Label-free C-reactive protein electronic detection with an electrolyte-gated organic field-effect transistor-based immunosensor

Publication year: 2016
Authors: Magliulo M. 1, De Tullio D. 2, Vikholm-Lundin I. 3, Albers W.M. 4, Munter T. 5, Manoli K. 2, Palazzo G. 2, Torsi L. 2
Published in: Analytical and Bioanalytical Chemistry, 2016, Vol. 408(15), p. 3943-52
In this contribution, we propose a label-free immunosensor, based on a novel type of electrolyte-gated field-effect transistor (EGOFET), for ultrasensitive detection of the C-reactive protein (CRP). [...]

Determining Number Concentrations and Diameters of Polystyrene Particles by Measuring the Effective Refractive Index of Colloids Using Surface Plasmon Resonance

Publication year: 2016
Authors: Tuoriniemi J. 1, Moreira B. 1, Safina G. 1,2
Published in: Langmuir, 2016, Vol. 32 (41), p. 10632–10640
The capabilities of surface plasmon resonance (SPR) for characterization of colloidal particles were evaluated for 100, 300, and 460 nm nominal diameter polystyrene (PS) latexes. First the accuracy of measuring [...]

Effect of PEG–PDMAEMA Block Copolymer Architecture on Polyelectrolyte Complex Formation with Heparin

Publication year: 2016
Authors: Välimäki S. 1, Khakalo A. 2, Ora A. 1, Johansson L.-S. 2, Rojas O.J. 2, Kostiainen M.A. 1
Published in: Biomacromolecules, 2016, Vol. 17(9), p. 2891-900
Heparin is a naturally occurring polyelectrolyte consisting of a sulfated polysaccharide backbone. It is widely used as an anticoagulant during major surgical operations. However, the associated bleeding risks require rapid neutralization after the operation. [...]

Surfaces Mimicking Glycosaminoglycans Trigger Different Response of Stem Cells via Distinct Fibronectin Adsorption and Reorganization

Publication year: 2016
Authors: Araújo A.R. 1,2, Soares da Costa D. 1,2, Amorim S. 1.2, Reis R.L. 1,2, Pires R.A. 1,2 Pashkuleva I. 1,2
Published in: ACS Applied Materials & Interfaces, 2016, Vol. 8 (42), p. 28428–28436
We report on the utility of a platform created by self-assembled monolayers to investigate the influence of the degree of sulfation of glycosaminoglycans (GAGs) on their interactions with fibronectin (Fn) and the impact [...]

Amine-appended polyaniline as a water dispersible electroactive polyelectrolyte and its integration into functional self-assembled multilayers

Publication year: 2016
Authors: Waldemar A. Marmisollé a, Eliana Mazaa b, Sergio Moya b, Omar Azzaroni a
Published in: Electrochimica Acta, 2016, Vol. 210, p. 435–444
We present an effective and simple method for the synthesis of poly(3-aminobenzylamine) (PABA) using a chemical oxidation strategy in aqueous solution. The polymer was characterized by NMR, LDI-TOF mass spectrometry, UV-visible, XPS and ATR-FTIR spectroscopies. [...]

Using electrochemical surface plasmon resonance for in-situ kinetic investigations of solid electrolyte interphase formation in lithium ion battery

Publication year: 2016
Authors: Pradanawati S.A. a, Wang F.-M. a, b, Su Ch.-H. c
Published in: Journal of Power Sources, Vol. 330, 2016, p. 127–131
The solid electrolyte interphase (SEI) significantly affects the energy density and safety performance of lithium ion batteries. Previous studies have shown that conventional analyses cannot characterize the real-time [...]

Lignocellulosic Materials and their Interactions with Proteins and Surface Active Molecules

Publication year: 2016
Authors: Fritz C.
Published in: Doctoral dissertation, North Carolina State University
Lignocellulosic biomass is a highly valuable resource for the development of value-added biobased chemicals and other materials. However, the efficient utilization of this biomass regards on understanding the different interactions [...]

Enzymes as Biodevelopers for Nano- And Micropatterned Bicomponent Biopolymer Thin Films

Publication year: 2016
Authors: Niegelhell K. 1, Süßenbacher M. 1, Jammernegg K. 1, Ganner T. 2, Schwendenwein D. 3, Schwab H. 3, Stelzer F. 1, Plank H. 2, Spirk S. 1,4
Published in: Biomacromolecules, 2016, Vol. 17 (11), p. 3743–3749
The creation of nano- and micropatterned polymer films is a crucial step for innumerous applications in science and technology. However, there are several problems associated with environmental aspects concerning the polymer synthesis itself, cross-linkers to induce the patterns as well as toxic solvents [...]

Optimization of lipodisk properties by modification of the extent and density of the PEG corona

Publication year: 2016
Authors: Zetterberg M.M. 1, Ahlgren S. 1, Agmo Hernández V. 1, Parveen N. 2, Edwards K. 1
Published in: Journal of Colloid and Interface Science, Vol. 484 (2016), p. 86–96
Lipodisks are nanosized flat, circular, phospholipid bilayers that are edge-stabilized by polyethylene glycol-conjugated lipids (PEG-lipids). Over the last decade, lipodisks stabilized [...]

Kinetic studies of bovine serum albumin interaction with PG and TBHQ using surface plasmon resonance

Publication year: 2016
Authors: Fathi F. a,b,c, Ezzati Nazhad Dolatanbadi J. a, Rashidi M.R. a, Omidi Y. a
Published in: International Journal of Biological Macromolecules, 2016, Vol. 91, p. 1045–1050
Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) are examples of phenolic antioxidant agents, which have widespread uses in food industry. In this study, for the first time, we report on the interaction of PG and TBHQ [...]

Dual-Wavelength Surface Plasmon Resonance for Determining the Size and Concentration of Sub-Populations of Extracellular Vesicles

Publication year: 2016
Authors: Rupert D.L.M. 1, Shelke G.V. 2, Emilsson G. 1, Claudio V. 1, Block S. 1, Lässer C. 2, Dahlin A. 1, Lötvall J.O. 2, Bally M. 1,3, Zhdanov V.P. 1,4, Höök F. 1
Published in: Analytical Chemistry, 2016, Vol. 88 (20), p. 9980–9988
Accurate concentration determination of subpopulations of extracellular vesicles (EVs), such as exosomes, is of importance both in the context of understanding their fundamental biological role [...]

Phenylboronic-Acid-Based Polymeric Micelles for Mucoadhesive Anterior Segment Ocular Drug Delivery

Publication year: 2016
Authors: Prosperi-Porta G. 1, Kedzior S. 2, Muirhead B. 1, Sheardown H. 1,2
Published in: Biomacromolecules, 2016, Vol. 17(4), p. 1449-57
Topical drug delivery to the front of the eye is extremely inefficient due to effective natural protection mechanisms such as precorneal tear turnover and the relative impermeability of the cornea and sclera tissues. This causes low ocular drug bioavailability, requiring large frequent doses that result in high systemic exposure and side effects.[...]

Real-Time Label-Free Monitoring of Nanoparticle Cell Uptake

Publication year: 2016
Authors: Suutari T. 1, Silen T. 1, S.en Karaman D. 2,3, Saari H. 1, Desai D. 2, Kerkelä E. 4, Laitinen S. 4, Hanzlikova M. 1, Rosenholm J.M. 2, Yliperttula M. 1,5, Viitala T. 6
Published in: Small
The surface plasmon resonance technique in combination with whole cell sensing is used for the first time for real-time label-free monitoring of nanoparticle cell uptake. The uptake kinetics of several types of nanoparticles [...]

Layer-by-layer assembly of functionalized reduced graphene oxide for direct electrochemistry and glucose detection

Publication year: 2016
Authors: Mascagni D.B. a, Miyazaki C.M. b, da Cruz N.C. a, de Moraes M.L. c, Riul A. Jr. d, Ferreira M. b
Published in: Materials Science and Engineering: C, 2016, Vol. 68, p. 739–745
We report an electrochemical glucose biosensor made with layer-by-layer (LbL) films of functionalized reduced graphene oxide (rGO) and glucose oxidase (GOx). The LbL assembly using positively and negatively charged rGO multilayers represents a simple approach to develop enzymatic biosensors. [...]

Differential Effect of Membrane Composition on the Pore-Forming Ability of Four Different Sea Anemone Actinoporins

Publication year: 2016
Authors: García-Linares S. 1, 2, Rivera-de-Torre E. 1, Morante K. 3, Tsumoto K. 3, Caaveiro J.M.M. 3, Gavilanes J.G. 1, Slotte J.P. 2, Martínez-del-Pozo A. 1
Published in: Biochemistry, 2016, Vol. 55 (48), p. 6630–6641
Sea anemone actinoporins constitute a protein family of multigene pore-forming toxins (PFT). Equinatoxin II (EqtII), fragaceatoxin C (FraC), and sticholysins I and II (StnI and StnII, respectively), produced by three different sea anemone species, are the only actinoporins [...]

Surface plasmon resonance for characterization of large-area atomic-layer graphene film

Publication year: 2016
Authors: H. Jussila 1,*, H. Yang 1, N. Granqvist 2, Z. Sun 1
Published in: Optica, Vol. 3, Issue 2, p. 151-158
Characterization of large-area thin films with atomic-scale resolution is challenging but in great demand for diverse applications (e.g., nanotechnology and sensing). Here, we use the Surface Plasmon Resonance (SPR) method to characterize both the thickness and refractive index of chemical-vapor-deposition (CVD)-grown graphene films. [...]

Role of the Tryptophan Residues in the Specific Interaction of the Sea Anemone Stichodactyla helianthus’s Actinoporin Sticholysin II with Biological Membranes

Publication year: 2016
Authors: García-Linares S. 1, 2, Maula T. 2, Rivera-de-Torre E. 1, Gavilanes J.G. 1, Slotte J.P. 2, Martínez-del-Pozo A. 1
Published in: Biochemistry, 2016, Vol. 55 (46), p. 6406–6420
Actinoporins are pore-forming toxins from sea anemones. Upon interaction with sphingomyelin-containing bilayers, they become integral oligomeric membrane structures that form a pore. [...]

Enzymatic Precipitation Enhanced Surface Plasmon Resonance Immunosensor for the Detection of Salmonella in Powdered Milk

Publication year: 2016
Authors: Farka Z. 1, Juřík T. 1, 2, Pastucha M. 1, 2, Skládal P.1, 2
Published in: Analytical Chemistry, 2016, Vol. 88 (23), p. 11830–11836
Contamination of food by pathogenic bacteria has always been a serious threat for human health. The amount of food exports and imports has been increasing in recent years which requires precise food quality control [...]

SPR Biosensing MUA/Poly-L-lysine Platform for the Detection of 2,4-Dinitrophenol as Small Molecule Model System

Publication year: 2016
Authors: Millone M.A.D. 1, Ramirez E.A. 1, Chain C.Y. 1, Crivaro A. 2, Romanin D. 2, Rumbo M. 2, Docena G. 2, Cocco M.D. 3, Pedano M.L. 3, Fainstein A. 3, Montoya J. 4, Vela M.E. 1, Salvarezza R.C. 1
Published in: Journal of Nanomaterials, Vol. 2016, Article ID 5432656, 9 p.
Surface Plasmon Resonance assays are being developed as alternative biodetection methods for a great number of pesticides and toxins. These substances typically have low molecular weight, [...]