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Label-free evaluation of carbon nanoparticles in Layer-by-Layer self-assembled enzyme-based biosensors

Publication year: 2017
Authors: David M. a, Florescu M. b, Barsan M. M. c, Brett M.A.C. c
Published in: Procedia Technology, Vo. 27, 2017, p. 304-305
The immobilization of biomolecules and the enhancement of the electron transfer are important factors regarding the performances of the enzyme-based biosensors. Layer-by-layer (LbL) strategies can be effectively used [...]

“Click” access to multilayer functionalized Au surface: A terpyridine patterning example

Publication year: 2017
Authors: F.A. Martin a, D. Marconi a, S. Neamtu a, T. Radu a, M. Florescu b, R. Turcu a, C. Lar c, N.D. Hădade c, I. Grosu c, I. Turcu a
Published in: Materials Science and Engineering: C, 2017, Vol. 75, p. 1343–1350
This work is focused on self-assembled monolayers (SAMs) fabrication, using two types of Au surfaces, by subsequent attachment of different layers in order to develop [...]

A Surface Plasmon Resonance Histamine Sensor Based on an Electropolymerized Molecularly Imprinted Polymer (E-MIP)

Publication year: 2017
Authors: Hubilla F.A.D., Mabilangan A.I., Advincula R.C., del Mundo F.R.
Published in: MATEC Web of Conferences, Vol. 95, 2017
In this paper, histamine sensing by surface plasmon resonance (SPR) spectroscopy using an electropolymerized molecularly imprinted polymer (E-MIP) of functionalized polyterthiophene and histamine is reported. [...]

Bovine Serum Albumin Adsorption at a Silica Surface Explored by Simulation and Experiment

Publication year: 2017
Authors: Kubiak-Ossovska K. 1, Tokarczyk K. 2, Jachimska B. 2, Mulheran A.P. 1
Published in: Journal of Physical Chemistry B, 2017, Vol. 121 (16), p. 3975–3986
Molecular details of BSA adsorption on a silica surface are revealed by fully atomistic molecular dynamics (MD) simulations (with a 0.5 μs trajectory), supported by dynamic light scattering (DLS), zeta potential, [...]

Surface Plasmon Resonance for Measuring Exocytosis from Populations of PC12 Cells: Mechanisms of Signal Formation and Assessment of Analytical Capabilities

Publication year: 2017
Authors: Moreira B. 1, Tuoriniemi J. 1, Kouchak Pour N. 1, Mihalčíková L.1, Safina G. 1,2
Published in: Analytical Chemistry, 2017, Vol. 89 (5), p. 3069–3077
Because of cell to cell variation, it is difficult to obtain statistically significant data on the frequency of exocytosis events (Rexocytosis, t–1 m–2) with traditional single cell electrophysiological [...]

Rapid and Highly Sensitive Detection of Dopamine Using Conjugated Oxaborole-Based Polymer and Glycopolymer Systems

Publication year: 2017
Authors: Jiang K., Wang Y., Thaku G., Kotsuchibashi Y., Naicker S., Narain R., Thundat T.
Published in: ACS Applied Materials & Interfaces, 2017, Vol. 9 (18), p. 15225–15231
A conjugated polymer interface consisting of an oxaborole containing polymer and a glycopolymer was used for achieving very high selectivity in dopamine (DA) detection. [...]

Layer-by-layer assemblies of highly connected polyelectrolyte capped-Pt nanoparticles for electrocatalysis of hydrogen evolution reaction

Publication year: 2017
Authors: Fenoy G.E. a, b, Maza E. a, c, Zelaya E. d, Marmisollé W.A. a, Azzaroni O. a
Published in: Applied Surface Science, 2017, Vol. 416, p. 24–32
Herein we present a simple one-step method to produce polyelectrolyte-capped Pt nanoparticles able to be assembled into layer-by-layer arrays [...]

Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer

Publication year: 2017
Authors: Soudy R. 1,2,5, Etayash H. 1, Bahadorani K.1, Lavasanifar A. 1,3, Kaur K. 1,4
Published in: Molecular Pharmaceutics, 2017, Vol. 14 (3), p. 593–604
The biomarkers or receptors expressed on cancer cells and the targeting ligands with high binding affinity for biomarkers play a key role in early detection and treatment of breast cancer. [...]

Filaments with Affinity Binding and Wet Strength Can Be Achieved by Spinning Bifunctional Cellulose Nanofibrils

Publication year: 2017
Authors: Vuoriluoto M. 1, Orelma H. 1, Lundahl M. 1, Borghe M. 1, Rojas O.J.1,2,3
Published in: Biomacromolecules, 2017, Vol.18 (6), p. 1803–1813
We demonstrate benzophenone (BP) conjugation via amine-reactive esters onto oxidized cellulosic fibers that were used as precursors, after microfluidization, of photoactive cellulose nanofibrils (CNF). [...]

Effect of Lipoxygenase Oxidation on Surface Deposition of Unsaturated Fatty Acids

Publication year: 2017
Authors: Tayeb A.H.1, Hubbe M.A.1, Zhang Y. 2 , Rojas O.J. 1,3
Published in: Langmuir, 2017, Vol. 33 (18), p. 4559–4566
We studied the interactions of lipid molecules (linoleic acid, glycerol trilinoleate and a complex mixture of wood extractives) with hydrophilic and hydrophobic surfaces (cellulose nanofibrils (CNFs) [...]

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Publication year: 2017
Authors: Carney R.P. 1, Hazari S. 1, Rojalin T. 2,3, Knudson A. 1, Gao T. 3,4, Tang Y. 3,4, Liu R. 1, Viitala T. 5, Yliperttula M. 5,6, Lam K.S. 1,7
Published in: Advanced Biosystems, 2017, Vol. 1 (5), p. 1600038
All cells expel a variety of nanosized extracellular vesicles (EVs), including exosomes, with composition reflecting the cells' biological state. Cancer pathology is dramatically mediated by EV trafficking [...]

Surface plasmon resonance biosensor for enzymatic detection of small analytes

Publication year: 2017
Authors: Miyazaki C.M., Shimizu F.M., Mejía-Salazar J.R., Oliveira O.N., Ferreira M.
Published in: Nanotechnology, 2017, Vol. 28(14), p. 145501
Surface plasmon resonance (SPR) biosensing is based on the detection of small changes in the refractive index on a gold surface modified with molecular recognition materials, thus being mostly limited to detecting large molecules. [...]

Quantitative interpretation of PAMAM dendrimers adsorption on silica surface

Publication year: 2017
Authors: Tokarczyk K., Jachimska B
Published in: Journal of Colloid and Interface Science, 2017 Vol. 503, p. 86-94
Understanding the dendrimer-solid support interaction is of great importance for dendrimer-based drug delivery system design. The maximum surface coverage on a hydrophilic silica surface was determined using [...]

Binding Kinetics and Lateral Mobility of HSV-1 on End-Grafted Sulfated Glycosaminoglycans

Publication year: 2017
Authors: Peerboom N. 1, Block S. 2, Altgärde N. 1, Wahlsten O. 1, Möller S. 3, Schnabelrauch M. 3, Trybala E. 4, Bergström T. 4, Bally M. 5
Published in: Biophysics Journal, 2017, Vol. 113, Issue 6, p. 1223-1234
Many viruses, including herpes simplex (HSV), are recruited to their host cells via interaction between their envelope glycoproteins and cell-surface glycosaminoglycans (GAGs). This initial attachment [...]

Effect of Molecular Architecture on Cell Interactions and Stealth Properties of PEG

Publication year: 2017
Authors: Ozer I. a,b, Tomak A. c, Zareie H.M. c,d, Baran Y. e,f Bulmus V. a,b
Published in: Biomacromolecules, 2017, Vol. 18 (9), p. 2699–2710
PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology [...]

Detachment of Membrane Bound Virions by Competitive Ligand Binding Induced Receptor Depletion

Publication year: 2017
Authors: Parveen N. 1, Block S. 1, Zhdanov V.P. 1,2, Rydell G.E. 3, Höök F. 1
Published in: Langmuir, 2017, Vol. 33 (16), p. 4049–4056
Multivalent receptor-mediated interactions between virions and a lipid membrane can be weakened using competitive nonpathogenic ligand binding. In particular, the subsequent binding [...]

Early-stage detection of VE-cadherin during endothelial differentiation of human mesenchymal stem cells using SPR biosensor

Publication year: 2017
Authors: Fathi F. 1, Rezabakhsh A. 2, Rahbarghazi R. 3, Rashidi M.R. 4
Published in: Biosensors and Bioelectronics, 2017, Vol. 96, p. 358-366
Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time dynamic analysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the need for labeling processes. [...]

Lignin Films from Spruce, Eucalyptus, and Wheat Straw Studied with Electroacoustic and Optical Sensors: Effect of Composition and Electrostatic Screening on Enzyme Binding

Publication year: 2017
Authors: Pereira A. 1,2, Hoeger I.C. 2, Ferrer A. 2 , Rencoret J. 1, del Rio J.C. 1, Kruus K. 3§, Rahikainen J. 3, Kellock M. 3, Gutiérrez A. 1, Rojas O.J. 2,4
Published in: Biomacromolecules, 2017, Vol. 18 (4), p. 1322–1332
Lignins were isolated from spruce, wheat straw, and eucalyptus by using the milled wood lignin (MWL) method. Functional groups and compositional analyses were assessed [...]

Effect of Ionic Strength and Surface Charge Density on the Kinetics of Cellulose Nanocrystal Thin Film Swelling

Publication year: 2017
Authors: Reid M.S. 1, Kedzior S.A. 1, Villalobos M. 2, Cranston E.D. 1
Published in: Langmuir, 2017, Vol. 33 (30), p. 7403–7411
This work explores cellulose nanocrystal (CNC) thin films (<50 nm) and particle–particle interactions by investigating film swelling in aqueous solutions with varying ionic strength [...]

How Bound and Free Fatty Acids in Cellulose Films Impact Nonspecific Protein Adsorption

Publication year: 2017
Authors: Niegelhell K. a, Suessenbacher M. b, Sattelkow J. c, Plank H. c, Wang Y. d, Zhang K. d, Spirk S. a
Published in: Biomacromolecules, 2017, Vol. 18 (12), p. 4224–4231
The effect of fatty acids and fatty acid esters to impair nonspecific protein adsorption on cellulose thin films is investigated. Thin films are prepared by blending trimethylsilyl cellulose solutions with either cellulose stearoyl ester [...]