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Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Kinetic and thermodynamic study of bovine serum albumin interaction with rifampicin using surface plasmon resonance and molecular docking methods

Publication year: 2017
Authors: Sharifi M. 1, Dolatabadi J.E. 2, Fathi F. 3, Rashidi M. 2, Jafari B. 4, Tajalli H. 1, Rashidi M.R. 2
Published in: Journal of Biomedical Optics, 2017, Vol. 22(3), p.
The interaction of bovine serum albumin (BSA) with various drugs, such as antibiotics, due to the importance of BSA in drug delivery has attracted increasing research attention at present. [...]

Surface plasmon resonance biosensor for enzymatic detection of small analytes

Publication year: 2017
Authors: Miyazaki C.M., Shimizu F.M., Mejía-Salazar J.R., Oliveira O.N., Ferreira M.
Published in: Nanotechnology, 2017, Vol. 28(14), p. 145501
Surface plasmon resonance (SPR) biosensing is based on the detection of small changes in the refractive index on a gold surface modified with molecular recognition materials, thus being mostly limited to detecting large molecules. [...]

Layer-by-layer self-assembly for carbon dots/chitosan-based multilayer: Morphology, thickness and molecular interactions

Publication year: 2017
Authors: T. da S.Pinto a, L.A. Alves a, G. de Azevedo Cardozo a, V.H.O. Munhoz a, R.M. Verly a, F.V. Pereira b, J.P. de Mesquita a
Published in: Materials Chemistry and Physics, Vol. 186 (2017), p. 81–89
Oxidized Carbon dots, prepared from the acid dehydration of cellulose, were used in the preparation of self-assembled films with the biopolymer chitosan. [...]

Early-stage detection of VE-cadherin during endothelial differentiation of human mesenchymal stem cells using SPR biosensor

Publication year: 2017
Authors: Fathi F. 1, Rezabakhsh A. 2, Rahbarghazi R. 3, Rashidi M.R. 4
Published in: Biosensors and Bioelectronics, 2017, Vol. 96, p. 358-366
Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time dynamic analysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the need for labeling processes. [...]

Interaction of Tissue Engineering Substrates with Serum Proteins and Its Influence on Human Primary Endothelial Cells

Publication year: 2017
Authors: Mohan T. 1, Niegelhell K. 2, Nagaraj C. 3,4, Reishofer D. 2,5, Spirk S. 2,5, Olschewski A. 3,4, Stana Kleinschek K. 5, Kargl R. 2,5
Published in: Biomacromolecules, 2017, Vol. 18 (2), p. 413–421
Polymer-based biomaterials particularly polycaprolactone (PCL) are one of the most promising substrates for tissue engineering.The surface chemistry of these materials plays a major role [...]

Surface Plasmon Resonance for Measuring Exocytosis from Populations of PC12 Cells: Mechanisms of Signal Formation and Assessment of Analytical Capabilities

Publication year: 2017
Authors: Moreira B. 1, Tuoriniemi J. 1, Kouchak Pour N. 1, Mihalčíková L.1, Safina G. 1,2
Published in: Analytical Chemistry, 2017, Vol. 89 (5), p. 3069–3077
Because of cell to cell variation, it is difficult to obtain statistically significant data on the frequency of exocytosis events (Rexocytosis, t–1 m–2) with traditional single cell electrophysiological [...]

Ionic strength-controlled hybridization and stability of hybrids of KRAS DNA single-nucleotides: A surface plasmon resonance study

Publication year: 2017
Authors: Giamblanco N. 1, Petralia S. 2, Conoci S. 3, Messineo C. 4, Marletta G. 4
Published in: Colloids and Surfaces B: Biointerfaces, 2017, Vol. 158, p. 41-46
The discrimination of a fully matched, unlabeled KRAS wild-type (WT) (C-G) target sample with respect to three of the most frequent KRAS codon mutations (G12 S (C-A), G12 R (C-C), G12C (C-T)) was investigated using an [...]

Improving the mechanical properties of CNF films by NMMO partial dissolution with hot calender activation

Publication year: 2017
Authors: Orelma H., Korpela A., Kunnari V., Harlin A., Suurnäkki A.
Published in: Cellulose 2017
Reinforcing of cellulose nanofibril (CNF) films by partial dissolution with N-methylmorpholine-N-oxide (NMMO) was investigated. The method investigated is composed of impregnation of CNF film [...]

Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer

Publication year: 2017
Authors: Soudy R. 1,2,5, Etayash H. 1, Bahadorani K.1, Lavasanifar A. 1,3, Kaur K. 1,4
Published in: Molecular Pharmaceutics, 2017, Vol. 14 (3), p. 593–604
The biomarkers or receptors expressed on cancer cells and the targeting ligands with high binding affinity for biomarkers play a key role in early detection and treatment of breast cancer. [...]

Detection of transferrin by using a surface plasmon resonance sensor functionalized with a boronic acid monolayer

Publication year: 2017
Authors: Yanchao Mayang 1,2, Xiwen He 1,2, Langxing Chen 1,2, Yukui Zhang 1,2,3
Published in: Microchimica Acta, 2017, Vol. 184 (8), p. 2749–2757
A surface plasmon resonance sensor whose surface has been modified with boronic acid groups was developed in order to bind and detect transferrin. 4-Mercaptophenylboronic acid (4-MPBA) was utilized [...]

Dangerous liaisons: anion-induced protonation in phosphate-polyamine interactions and their implications for charge states of biologically relevant surfaces

Publication year: 2017
Authors: Laucirica G., Marmisollé W.A., Azzaroni O.
Published in: Physical Chemistry Chemical Physics, 2017, Vol. 19 (12), p. 8612-8620
Although not always considered a preponderant interaction, amine-phosphate interactions are omnipresent in multiple chemical and biological systems. [...]

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Publication year: 2017
Authors: Carney R.P. 1, Hazari S. 1, Rojalin T. 2,3, Knudson A. 1, Gao T. 3,4, Tang Y. 3,4, Liu R. 1, Viitala T. 5, Yliperttula M. 5,6, Lam K.S. 1,7
Published in: Advanced Biosystems, 2017, Vol. 1 (5), p. 1600038
All cells expel a variety of nanosized extracellular vesicles (EVs), including exosomes, with composition reflecting the cells' biological state. Cancer pathology is dramatically mediated by EV trafficking [...]

Integration of Biorecognition Elements on PEDOT Platforms through Supramolecular Interactions

Publication year: 2017
Authors: Sappia L.D. 1,2, Piccinini E. 3, Marmisollé W. 3, Santilli N. 1, Maza E. 4, Moya S. 4, Battaglini F. 5, Madrid R.E. 1,2, Azzaroni O. 3
Published in: Advanced Materials Interfaces, 2017, 1700502
The rapidly emerging field of organic bioelectronics exploits the functional versatility of conducting polymers to transduce biological recognition events into electronic signals. For the majority of biosensors [...]