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Lectins at Interfaces—An Atomic Force Microscopy and Multi-Parameter-Surface Plasmon Resonance Study

Publication year: 2018
Authors: Niegelhell K. 1, Ganner T. 2, Plank H. 3, Jantscher-Krenn E. 4, Spirk S. 5
Published in: Materials 2018, Vol. 11(12), p. 2348
Lectins are a diverse class of carbohydrate binding proteins with pivotal roles in cell communication and signaling in many (patho)physiologic processes in the human body, making them promising [...]

Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects

Publication year: 2018
Authors: Koivusalo L. a, Karvinen J. e, Sorsa E. b, Jönkkäri I. c, Väliaho J. b, Kallio P. b, Ilmarinen T. a, Miettinen S. a, Skottman H. a, Kellomäki M. a, b
Published in: Materials Science and Engineering: C, Vol. 85, 2018, p. 68–78
Corneal blindness is a worldwide problem, plagued by insufficient amount of high-quality donor tissue. Cell therapy using human adipose stem cells (hASCs) has risen as an alternative [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Cyclopropylamine plasma polymer surfaces for label-free SPR and QCM immunosensing of Salmonella

Publication year: 2018
Authors: Makhneva E. a, b, Farka Z. c, Skladal P. c, d, Zajickova L. a,b
Published in: Sensors and Actuators B: Chemical, 2018
We report on the first successful application of nitrogen-containing functional surfaces prepared by plasma polymerization in surface plasmon resonance (SPR) immunosensing. The plasma polymers (PPs) [...]

Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Publication year: 2018
Authors: Orelma H. 1, Virtanen T. 1, Spoljaric S. 2, Lehmonen J. 1, Seppälä J. 2, Rojas O.J. 3, Harlin A. 1
Published in: Biomacromolecules, 2018, Vol. 19 (2), p. 652–661
A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic [...]

Interaction of lecithin-cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I derived peptides

Publication year: 2018
Authors: Casteleijn M. G., Parkkila P., Viitala T., Koivuniemi A.
Published in: Journal of Lipid Research, 2018
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme responsible for the formation of cholesteryl esters from unesterified cholesterol (UE) and phospholipid (PL) molecules in high-density lipoprotein (HDL) particles. [...]

Tuning the Stiffness of Surfaces by Assembling Genetically Engineered Polypeptides with Tailored Amino Acid Sequence

Publication year: 2018
Authors: Costa R.R. 1,2, González-Pérez M. 3,4, Herrero-Gutiérrez M. 3,4, Pires R.A. 1,2,5, Alonso M. 3,4, Rodriguez-Cabello J.C. 3,4, Reis R.L. 1,2,5, Pashkuleva I. 1,2
Published in: Biomacromolecules, 2018, Vol. 19(8), p. 3401-3411
We introduce elastin-like recombinamers (ELRs) as polypeptides with precise amino acid positioning to generate polypeptide coatings with tunable rigidity. Two ELRs [...]

Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Publication year: 2018
Authors: Magarkar A. a,b, Parkkila P. a, Viitala T. a, Lajunen T. a, Mobarak E. c,d, Licari G. e, Cramariuc O. c, Vauthey E. e , Rógc T. d, Bunker A.* a
Published in: Chemical Communications, 2018, Vol. 54, Issue 28, p. 3440-3443
The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms. Of these MB-COMT is a drug target [...]

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Taste masking effect of chlorogenic acid (CGA) on bitter drugs evaluated by taste sensor and surface plasmon resonance on the basis of CGA-Drug interactions

Publication year: 2017
Authors: Shiraishi S.1, Haraguchi T., Nakamura S., Li D., Kojima H., Yoshida M., Uchida T.
Published in: Chemical and Pharmaceutical Bulletin, Vol. 65 (2017), No. 2, p. 127-13
The purpose of this study was to evaluate the taste-masking effects of chlorogenic acid (CGA) on bitter drugs using taste sensor measurements and surface plasmon resonance (SPR) analysis of CGA-drug interactions. [...]

Rapid and Highly Sensitive Detection of Dopamine Using Conjugated Oxaborole-Based Polymer and Glycopolymer Systems

Publication year: 2017
Authors: Jiang K., Wang Y., Thaku G., Kotsuchibashi Y., Naicker S., Narain R., Thundat T.
Published in: ACS Applied Materials & Interfaces, 2017, Vol. 9 (18), p. 15225–15231
A conjugated polymer interface consisting of an oxaborole containing polymer and a glycopolymer was used for achieving very high selectivity in dopamine (DA) detection. [...]

Homogeneous cellulose thin films by regeneration of cellulose xanthate: properties and characterization

Publication year: 2017
Authors: Weißl M. 1, 2, Niegelhell K. 2, Reishofer D. 2, Zankel A. 3, Innerlohinger J. 4, Spirk S. 2
Published in: Cellulose, 2017, Vol. 25, Issue 1, p. 711-721
The preparation and characterization of cellulose thin films derived from cellulose xanthate is reported. The films are prepared by depositing alkaline aqueous solutions cellulose xanthate onto silicon wafers, followed by [...]

Endothelial cells' biophysical, biochemical, and chromosomal aberrancies in high ‐ glucose condition within the diabetic range

Publication year: 2017
Authors: Rezabakhsh A. 1,2, Nabat E. 2,3, Yousefi M. 4, Montazersaheb S. 2,5, Cheraghi O. 6, Mehdizadeh A. 7, Fathi F.8, Movassaghpour A.A. 9, Maleki-DIzaji N. 10, Rahbarghazi R. 2,11, Garjani A. 1,2,10
Published in: Cell Biochemistry & Function, 2017, p. 1-15
To date, many studies have been conducted to find out the underlying mechanisms of hyperglycemia-induced complications in diabetes mellitus, attributed to the cellular pathologies of different cells[...]

Filaments with Affinity Binding and Wet Strength Can Be Achieved by Spinning Bifunctional Cellulose Nanofibrils

Publication year: 2017
Authors: Vuoriluoto M. 1, Orelma H. 1, Lundahl M. 1, Borghe M. 1, Rojas O.J.1,2,3
Published in: Biomacromolecules, 2017, Vol.18 (6), p. 1803–1813
We demonstrate benzophenone (BP) conjugation via amine-reactive esters onto oxidized cellulosic fibers that were used as precursors, after microfluidization, of photoactive cellulose nanofibrils (CNF). [...]

Surface plasmon resonance methodology for monitoring polymerization kinetics and morphology changes of brushes-evaluated with poly(N-isopropylacrylamide)

Publication year: 2017
Authors: G. Emilsson a, R.L. Schoch b, P. Oertle b, K. Xiong a, R.Y. H. Lim b, A.B. Dahlin a
Published in: Applied Surface Science, Vol. 396, p. 384-392
Polymerization from surfaces and the resulting “brushes” have many uses in the development of novel materials and functional interfaces. However, it is difficult to accurately monitor the polymerization rate, [...]

Kinetic and thermodynamic study of bovine serum albumin interaction with rifampicin using surface plasmon resonance and molecular docking methods

Publication year: 2017
Authors: Sharifi M. 1, Dolatabadi J.E. 2, Fathi F. 3, Rashidi M. 2, Jafari B. 4, Tajalli H. 1, Rashidi M.R. 2
Published in: Journal of Biomedical Optics, 2017, Vol. 22(3), p.
The interaction of bovine serum albumin (BSA) with various drugs, such as antibiotics, due to the importance of BSA in drug delivery has attracted increasing research attention at present. [...]

Surface plasmon resonance biosensor for enzymatic detection of small analytes

Publication year: 2017
Authors: Miyazaki C.M., Shimizu F.M., Mejía-Salazar J.R., Oliveira O.N., Ferreira M.
Published in: Nanotechnology, 2017, Vol. 28(14), p. 145501
Surface plasmon resonance (SPR) biosensing is based on the detection of small changes in the refractive index on a gold surface modified with molecular recognition materials, thus being mostly limited to detecting large molecules. [...]

Layer-by-layer self-assembly for carbon dots/chitosan-based multilayer: Morphology, thickness and molecular interactions

Publication year: 2017
Authors: T. da S.Pinto a, L.A. Alves a, G. de Azevedo Cardozo a, V.H.O. Munhoz a, R.M. Verly a, F.V. Pereira b, J.P. de Mesquita a
Published in: Materials Chemistry and Physics, Vol. 186 (2017), p. 81–89
Oxidized Carbon dots, prepared from the acid dehydration of cellulose, were used in the preparation of self-assembled films with the biopolymer chitosan. [...]

Early-stage detection of VE-cadherin during endothelial differentiation of human mesenchymal stem cells using SPR biosensor

Publication year: 2017
Authors: Fathi F. 1, Rezabakhsh A. 2, Rahbarghazi R. 3, Rashidi M.R. 4
Published in: Biosensors and Bioelectronics, 2017, Vol. 96, p. 358-366
Surface plasmon resonance (SPR) biosensors are most commonly applied for real-time dynamic analysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the need for labeling processes. [...]

Interaction of Tissue Engineering Substrates with Serum Proteins and Its Influence on Human Primary Endothelial Cells

Publication year: 2017
Authors: Mohan T. 1, Niegelhell K. 2, Nagaraj C. 3,4, Reishofer D. 2,5, Spirk S. 2,5, Olschewski A. 3,4, Stana Kleinschek K. 5, Kargl R. 2,5
Published in: Biomacromolecules, 2017, Vol. 18 (2), p. 413–421
Polymer-based biomaterials particularly polycaprolactone (PCL) are one of the most promising substrates for tissue engineering.The surface chemistry of these materials plays a major role [...]