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Continuous assembly of supramolecular polyamine–phosphate networks on surfaces: preparation and permeability properties of nanofilms

Publication year: 2019
Authors: Agazzi M.L. a, Herrera S.E. a, Cortez M.L. a, Marmisollé W.A. a, von Bilderling C. a,b, Pietrasanta L.I. b,c, Azzaroni O. *a
Published in: Soft Matter, 2019, 15, p. 1640-1650
Supramolecular self-assembly of molecular building blocks represents a powerful “nanoarchitectonic” tool to create new functional materials with molecular-level feature control. Here, we propose [...]

The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease

Publication year: 2019
Authors: Lee B.H. 1, Kim S.H. 1, Ko Y. 2, Park J.C. 3, Ji S. 4, Gu M.B. 5
Published in: Biosensors and Bioelectronics, 2019, Vol. 126, p. 122-128
This research aims to develop biosensors which could diagnose periodontal diseases in early phases and predict the illness stage of patients, in order to give them adequate treatment timely. [...]

Analytical Model To Describe the Effect of Polyethylene Glycol on Ionic Screening of Analyte Charges in Transistor-Based Immunosensing

Publication year: 2019
Authors: Haustein N., Gutierrez-Sanz O., Tarasov. A
Published in: ACS Sensors, 2019, Vol. 4, Issue 4, p. 874-882
Recently, the co-immobilization of polyethylene glycol has improved sensor responses of transistor-based immunosensing by approximately three times. However, there is currently [...]

Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes

Publication year: 2019
Authors: Ierich J.C.M. 1,2, Brum D.G. 3, Moraes A.S. 1,2, Higa A.M. 1,2, Garcia P.S. 1,2, Miyazaki C.M. 4, Ferreira M. 4, Peroni L.A. 5, Oliveira G.S. 6, Franca E.F. 6, Freitas L.C.G. 7, Leite F.L. 8
Published in: Scientific Reports, 2019, Vol. 9, Issue 1, p. 2033
Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential [...]

Self-assembled hybrid nanocomposite films of carbon dots and hydrolyzed collagen

Publication year: 2019
Authors: da Pinto T.S. a, Rodrigues P.N.S. a, Marinho L.E.S. a, Verly R.M. a, Bretas Roa J.P. 1, de Oliveira L.C.Z. b, Pereira F.V. b, de Magalhaes M.T.Q. c,d, de Mesquita J.P. a
Published in: Materials Chemistry and Physics, 2019, Vol. 230, p. 44-53
In the present work, hydrophilic carbon dots (CD) prepared by cotton cellulose were used in the building of self-assembled films with hydrolyzed collagen (CL) to verify [...]

Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures

Publication year: 2019
Authors: Islam N. a,b, Gurgel P.V. a,c, Rojas O.J. a,d, Carbonell R.G. a,e
Published in: Bioconjugate Chemistry, 2019, Vol. 30, p. 815−825
Tris(2-aminoethyl)-amine (TREN), a branched amine, was coupled to planar surfaces of alkanethiol self-assembled monolayers (SAMs) to increase [...]

Enzyme Immobilization in Polyelectrolyte Brushes: High Loading and Enhanced Activity Compared to Monolayers

Publication year: 2019
Authors: del Castillo G.F-D. a, Koenig M. b, Mueller M. b, d, Eichhorn K.-J. b, Stamm M. b,d, Uhlmann P. b,c, Dahlin A. a
Published in: Langmuir, 2019, Vol. 35, p. 3479-3489
Catalysis by enzymes on surfaces has many applications. However, strategies for efficient enzyme immobilization with preserved activity are still in need of further development. [...]

Maleic anhydride and acetylene plasma copolymer surfaces for SPR immunosensing

Publication year: 2019
Authors: Makhneva E. 1,2, Farka Z. 3, Pastucha M. 4,5, Obrusník A. 1,2, Horáčková V. 4, Skládal P. 4,5, Zajíčková L. 1,2
Published in: Analytical and Bioanalytical Chemisry, 2019
We report on the successful application of carboxyl-rich plasma polymerized (PP) films as a matrix layer for bioreceptor immobilization in surface plasmon resonance (SPR) immunosensing. Composition and [...]

Layer‐by‐Layer Formation of Polyamine‐Salt Aggregate/Polyelectrolyte Multilayers. Loading and Controlled Release of Probe Molecules from Self‐Assembled Supramolecular Networks

Publication year: 2019
Authors: Herrera S.E. 1, Agazzi M.L. 1, Cortez M.L. 1, Marmisollé W.A. 1, von Bildering C. 1,2, Azzaroni O. 1
Published in: Macromolecular Chemistry and Physics, 2019
The use of soft materials as building blocks in layer‐by‐layer (LbL) assemblies represent a very appealing and useful approach to enhance the loading capacity of thin films. Here, the capacity of positively charged polyamine‐salt aggregates (PSAs) [...]

Self-assembled hybrid nanocomposite films of carbon dots and hydrolyzed collagen

Publication year: 2019
Authors: Tarciane da S. Pinto a, Priscilla N.S. Rodrigues a, Luiz E.S. Marinho a, Rodrigo M. Verly a, J.P. Bretas Roa a, Luiz C.A. de Oliveira b, Fabiano V. Pereira b, Mariana T.Q. de Magalhães c,d, João P. de Mesquita a
Published in: Materials Chemistry and Physics, 2019, Vol. 230, p. 44-53
In the present work, hydrophilic carbon dots (CD) prepared by cotton cellulose were used in the building of self-assembled films with hydrolyzed collagen (CL) to verify their properties, especially molecular interactions and morphology. [...]

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Publication year: 2019
Authors: Koponen A. a, Arora A. a, Takahashi K. b, Kentala H. a, Kivelä A.M. a, Jääskeläinen E. a, Peränen J. b, Somerharju P. c, Ikonen E. b, Viitala T. d, Olkkonen V.M. a,b
Published in: Biochimie, 2019, Vol. 158, p. 90-101
ORP2 is a sterol-binding protein with documented functions in lipid and glucose metabolism, Akt signaling, steroidogenesis, cell adhesion, migration and proliferation. [...]

Design and evaluation of a multiplexed angular-scanning surface plasmon resonance system employing line-laser optics and CCD detection in combination with multi-ligand sensor chips

Publication year: 2019
Authors: Lakayan D. a, Tuppurainen J. c, Suutari T.E. a,d, van Iperen D.J. e, Somsen G.W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, 2019, Vol. 282, p. 243-250
An angle-scanning Kretschmann configuration SPR instrument allowing multiplexed analysis is presented. Laser light was guided through optics that converted the collimated light into a line-shaped beam, which was [...]

Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity

Publication year: 2019
Authors: Torres L.M.F.C. a, Almeida M.T. a, Santos T.L. a, Marinho L.E.S. a, de Mesquita J.P. a, da Silva L.M. a, dos Santos W.T.P. b, Martins H.R. b, Kato K.C. b, Alves E.S.F. c, Liao L.M. c, .de Magalhães M.T.Q d, de Mendonça F.G. e, Pereira F.V. e, Resende J.M. e, Bemquerer M.P. f, Rodrigues M.A. g, Verly R.M. a
Published in: Colloids and Surfaces B: Biointerfaces , 2019, Vol. 177, p. 94-104
Due to the its physical-chemical properties, alumina nanoparticles have potential applications in several areas, such as nanobiomaterials [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

A DNA–nanoparticle actuator enabling optical monitoring of nanoscale movements induced by an electric field

Publication year: 2018
Authors: Tapio K. a, Shao D. a, Auer S. b, Tuppurainen J. c, Ahlskog M. a, Hytönen V.P. b, Toppari J.J. a*
Published in: Nanoscale, 2018, Vol. 10, p. 19297-19309
Merging biological and non-biological matter to fabricate nanoscale assemblies with controllable motion and function is of great interest due to its potential application, for example, in diagnostics and biosensing. [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Molecular Therapy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

The Influence of PEG-Thiol Derivatives on Controlling Cellular and Bacterial Interactions with Gold Surfaces

Publication year: 2018
Authors: Al-Ani A., Boden A., Al Kobaisi M., Pingle H., Wang P.-Y., Kingshott P.
Published in: Applied Surface Science, 2018, Vol. 462, p. 980-990
Surface modification with hydrophilic polymers is used extensively in a range of biomedical applications in order to control the interactions with proteins, cells and bacteria. owever, the architecture of the polymer layers [...]

Quantitative Analysis of Thickness and pH Actuation of Weak Polyelectrolyte Brushes

Publication year: 2018
Authors: Ferrand-Drake del Castillo G., Emilsson G., Dahlin A.
Published in: The Journal of Physical Chemistry C, 2018, Issue 122 (48), p. 27516–27527
Polymer brushes are widely used as surface coatings for various inert, functional, or responsive interfaces. If the polymer can alter its protonation state (a polyelectrolyte (PE)), the brush can switch [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]