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Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Bovine serum albumin binding study to erlotinib using surface plasmon resonance and molecular docking methods

Publication year: 2018
Authors: Taghipour P. 1, Zakariazadeh M. 2, Sharifi M. 3, Ezzati Nazhad Dolatabadi J. 4, Barzegar A. 5
Published in: Journal of Photochemistry and Photobiology B, 2018, Vol. 183, p. 11-15
Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with erlotinib [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

Improved glucose label-free biosensor with layer-by-layer architecture and conducting polymer poly(3,4-ethylenedioxythiophene)

Publication year: 2018
Authors: David M. a, b, Barsan M. M. a, Brett M.A.C. a, Florescu M. b
Published in: Sensors and Actuators B, 2018, Vol. 22, Issue 3, p. 3227-3234
Layer-by-layer (LbL) self-assembly has been used for the development of a new glucose label-free biosensor. Glucose oxidase (GOx) was incorporated in a multilayer film on a gold electrode, previously modified [...]

Generation and validation of murine monoclonal and camelid recombinant single domain antibodies specific for human pancreatic glycoprotein 2

Publication year: 2018
Authors: Schlör A. a, Holzlöhner P. a, Listek M. a, Griess C. a, Butze M. a, Micheel B. a, Hentschel Ch. b, Sowa M. b, Roggenbuck D. b,c, Schierack P. c, Füner J. d, Schliebs E. d, Goihl A. e, Reinhold D. e, Hanack K. a
Published in: New Biotechnology, 2018
Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified as a major autoantigenic target in Crohn’s disease patients. It was reported recently that a long (GP2a) and a short (GP2b) isoform [...]

Dynamic dispersal of surface layer biofilm induced by n-TiO2 based on surface plasmon resonance and waveguide

Publication year: 2018
Authors: Zhang P. 1,2, Guo J.S. 3, Yan P. 2, Chen Y.P. 4,2, Wang W. 5, Dai Y.Z. 1, Fang F. 2, Wang G.X. 6, Shen Y. 7
Published in: Applied and Environmental Microbiology, 2018
Pollutant degradation is mainly presented in the surface layer of biofilm, while the surface layer is the most vulnerable to the impairment of toxic pollutants. In this work, the effect of nanosized TiO2 [...]

Advancing Peptide-Based Biorecognition Elements for Biosensors Using In-Silico Evolution

Publication year: 2018
Authors: Xiao X. 1, Kuang Z. 2, Slocik J.M. 2, Tadepalli S. 4, Brothers M. 3, Kim S. 3, Mirau P.A. 2, Butkus C. 2, Farmer B.L. 2, Singamaneni S. 4, Hall C.K. 1, Naik R.R. 3
Published in: ACS Sensors, 2018, Vol. 3, Issue 5, p. 1024–1031
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]

Target-triggering multiple-cycle signal amplification strategy for ultrasensitive detection of DNA based on QCM and SPR

Publication year: 2018
Authors: Song W. 1, Guo X. 1, Sun W. 2, Yin W. 1, He P. 1, Yang X. 1, Zhang X. 3
Published in: Analytical Biochemisry, 2018, p. 57-61
Detection of ultralow concentrations of nucleic acid sequences is a central challenge in the early diagnosis of genetic diseases. Herein, we developed a target-triggering cascade multiple cycle amplification for ultrasensitive DNA detection using [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Moleuclar Theraphy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

Phase-segregated Membrane Model assessed by a combined SPR-AFM Approach

Publication year: 2018
Authors: Millone D.A.M. 1, Vázquez R.F. 1, Maté S.M. 2, Vela M.E. 3
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 172, p. 423-429
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

Publication year: 2018
Authors: Barattin M. 1, Mattarei A. 2, Balasso A. 1, Paradisi C. 2, Cantù L. 3, Del Favero E. 3, Viitala T. 4, Mastrotto F. 1, Caliceti P. 1, Salmaso S. 1
Published in: ACS Applied Materials & Interfaces, 2018, Vol. 10 (21), p. 17646–17661
An innovative pH-switchable colloidal system that can be exploited for site-selective anticancer drug delivery has been generated by liposome decoration with a new novel synthetic non-peptidic [...]

The Influence of PEG-Thiol Derivatives on Controlling Cellular and Bacterial Interactions with Gold Surfaces

Publication year: 2018
Authors: Al-Ani A., Boden A., Al Kobaisi M., Pingle H., Wang P.-Y., Kingshott P.
Published in: Applied Surface Science, 2018, Vol. 462, p. 980-990
Surface modification with hydrophilic polymers is used extensively in a range of biomedical applications in order to control the interactions with proteins, cells and bacteria. owever, the architecture of the polymer layers [...]

Molecular Details of Retinal Guanylyl Cyclase 1/GCAP-2 Interaction

Publication year: 2018
Authors: Rehkamp A. 1, Tänzler D. 1, Iacobucci C. 1, Golbik R.P. 2, Ihling C.H. 1, Sinz A. 1
Published in: Frontiers in Molecular Neuroscience, 2018, Vol. 11
The rod outer segment guanylyl cyclase 1 (ROS-GC1) is an essential component of photo-transduction in the retina. In the light-induced signal cascade, membrane-bound ROS-GC1 restores cGMP levels [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine

Publication year: 2018
Authors: Berninger T. a, Bliem C. a, Piccinini E. b, Azzaroni O. b, Knoll W. a
Published in: Biosensors and Bioelectronics, 2018, Vol. 115, p. 104-110
Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine. Arginase [...]

In operando measurements of kinetics of solid electrolyte interphase formation in lithium-ion batteries

Publication year: 2018
Authors: Alemu T. a, Pradanawati S.A. a,b, Chang S.-C. a, Lin P.-L. a, Kuo Y.-L. c, Pham Q.-T. a, Su C.-H. d, Wang F.-M. a,e
Published in: Journal of Power Sources, 2018, Vol. 400, p. 426-433
This study applied two in operando techniques to reveal the reaction kinetics of solid electrolyte interphase formation on electrolyte and benzimidazole salt additives. The results obtained from studying interface effects reveal [...]

Affinity profiling of monoclonal antibody and antibody-drug-conjugate preparations by coupled liquid chromatography-surface plasmon resonance biosensing

Publication year: 2018
Authors: Lakayan D. 1,2, Haselberg R. 1, Gahoual R. 1,3, Somsen G.W. 1, Kool J. 4
Published in: Analytical and Bioanalytical Chemisry, 2018, p. 1-12
Monoclonal antibodies (mAbs) and antibody-drug conjugates (ADCs) are highly potent biopharmaceuticals designed for targeted cancer therapies. mAbs and ADCs can undergo modifications during [...]