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Cyclodextrin-Functionalized Fiber Yarns Spun from Deep Eutectic Cellulose Solutions for Nonspecific Hormone Capture in Aqueous Matrices

Authors: Orelma H. 1, Virtanen T. 1, Spoljaric S. 2, Lehmonen J. 1, Seppälä J. 2, Rojas O.J. 3, Harlin A. 1
Published in: Biomacromolecules, 2018, Vol. 19 (2), p. 652–661
A wood based yarn platform for capturing pharmaceutical molecules from water was developed. Cellulose fiber yarns were modified with cyclodextrins, and the capture of 17α-ethinyl estradiol (EE2), a synthetic [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Dynamic dispersal of surface layer biofilm induced by n-TiO2 based on surface plasmon resonance and waveguide

Authors: Zhang P. 1,2, Guo J.S. 3, Yan P. 2, Chen Y.P. 4,2, Wang W. 5, Dai Y.Z. 1, Fang F. 2, Wang G.X. 6, Shen Y. 7
Published in: Applied and Environmental Microbiology, 2018
Pollutant degradation is mainly presented in the surface layer of biofilm, while the surface layer is the most vulnerable to the impairment of toxic pollutants. In this work, the effect of nanosized TiO2 [...]

Salt-Induced Control of the Grafting Density in Poly(ethylene glycol) Brush Layers by a Grafting-to Approach

Authors: Ortiz R. 1, Olsen S. 2, Thormann E. 1
Published in: Langmuir, 2018
In this work, a method to obtain control of the grafting density during the formation of polymer brush layers by the grafting-to method of thiolated poly(ethylene glycol) onto gold is presented. [...]

Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Authors: Magarkar A. a,b, Parkkila P. a, Viitala T. a, Lajunen T. a, Mobarak E. c,d, Licari G. e, Cramariuc O. c, Vauthey E. e , Rógc T. d, Bunker A.* a
Published in: Chemical Communications, 2018, Vol. 54, Issue 28, p. 3440-3443
The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms. Of these MB-COMT is a drug target [...]

Characterization of IFN-γ Detection and Electrochemical Proximity Assay by a Novel Multi-Parametric/Multimodal Spectroscopy Apparatus

Publication year: 2017
Authors: Zhou L., Chin B. A., Simonian A. L.*
Published in: ECS Transactions, 2017, Vol. 80, Issue 10, p. 1565-1570
Functional interfaces play a vital role in biosensing, which requires proper allocation, orientation, conformation, activities and stability to achieve high affinity and stability of the biomolecules. However, the characterization [...]

Carboxyl-rich plasma polymer surfaces in surface plasmon resonance immunosensing

Publication year: 2018
Authors: Makhneva E. 1, 2, 6, Obrusnik A. 1, 2, 6, Farka Z. 3, Skladal P. 3, 4, Vandenbossche M. 5, Hegemann D. 5, Zajickova L. 1, 2
Published in: Japanese Journal of Applied Physics, 2018, Vol. 57, Number 1S, 01AG06
Stable carboxyl-rich plasma polymers (PPs) were deposited onto the gold surface of surface plasmon resonance (SPR) chips under conditions that were chosen based on lumped kinetic model results. Carboxyl-rich films are [...]

Homogeneous cellulose thin films by regeneration of cellulose xanthate: properties and characterization

Publication year: 2017
Authors: Weißl M. 1, 2, Niegelhell K. 2, Reishofer D. 2, Zankel A. 3, Innerlohinger J. 4, Spirk S. 2
Published in: Cellulose, 2017, Vol. 25, Issue 1, p. 711-721
The preparation and characterization of cellulose thin films derived from cellulose xanthate is reported. The films are prepared by depositing alkaline aqueous solutions cellulose xanthate onto silicon wafers, followed by [...]

Lignocellulosic Materials and their Interactions with Proteins and Surface Active Molecules

Publication year: 2016
Authors: Fritz C.
Published in: Doctoral dissertation, North Carolina State University
Lignocellulosic biomass is a highly valuable resource for the development of value-added biobased chemicals and other materials. However, the efficient utilization of this biomass regards on understanding the different interactions [...]

Investigation of graphene-on-metal substrates for SPR-based sensor using finite-difference time domain

Publication year: 2017
Authors: Said F. A. 1, Menon P. S. 1, Rajendran V. 2, Shaari S. 1, Majlis B. Y. 1
Published in: IET Nanobiotechnology, 2017, Vol. 11, Issue 8, p. 981 – 986
In this study, the authors investigated the effects of a single layer graphene as a coating layer on top of metal thin films such as silver, gold, aluminum and copper using finite-difference time domain method. [...]

Kinetic and thermodynamic studies of bovine serum albumin interaction with ascorbyl palmitate and ascorbyl stearate food additives using surface plasmon resonance

Publication year: 2018
Authors: Fathi F. a, Mohammadzadeh-Aghdash H. b, c, Sohrabi Y. b, c, Dehghan P. b, Ezzati J. N. D. a
Published in: Food Chemistry, 2018, Vol. 246, p.228-232
Ascorbyl palmitate (AP) and ascorbyl stearate (AS) are examples of food additives, which have extensive use in food industry. In this study, we evaluated the interaction of bovine serum albumin (BSA) with [...]

Label-free biosensors in the field of stem cell biology

Publication year: 2018
Authors: Fathi F. a, Rahbarghazi R. b, c, Rashidi M.-R. a, d
Published in: Biosensors and Bioelectronics, 2018, Vol. 101, p. 188-198
A great body of evidence unveiled the existence of different stem cell types in various tissues with efficient capability for self-renewal and differentiation. Characterization and enumeration [...]

Interaction of lecithin-cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I derived peptides

Publication year: 2018
Authors: Casteleijn M. G., Parkkila P., Viitala T., Koivuniemi A.
Published in: Journal of Lipid Research, 2018
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme responsible for the formation of cholesteryl esters from unesterified cholesterol (UE) and phospholipid (PL) molecules in high-density lipoprotein (HDL) particles. [...]

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Publication year: 2018
Authors: Casteleijn M. G. a, Richardson D. a, Parkkila P. a, Granqvist N. b, Urtti A. a, c, Viitala T. a
Published in: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, Vol. 539, p. 261-272
Chitin, abundant in nature, is a renewable resource with many possible applications in bioengineering. Biosensors, capable of label-free and in-line evaluation, play an important role in the investigation of [...]

On the Importance of Controlling Film Architecture in Detecting Prostate Specific Antigen

Publication year: 2018
Authors: Graça J. S. a, Miyazaki C. M. a, Shimizu F. M. b, Volpati D. c, Mejía-Salazar J. R. b, Oliveira O.N. Jr. b, Ferreira M. a
Published in: Applied Surface Science, 2018, Vol. 434, p. 1175-1182
Immunosensors made with nanostructured films are promising for detecting cancer biomarkers, even at early stages of the disease, but this requires control of film architecture to preserve [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Hydrazone crosslinked hyaluronan-based hydrogels for therapeutic delivery of adipose stem cells to treat corneal defects

Publication year: 2018
Authors: Koivusalo L. a, Karvinen J. e, Sorsa E. b, Jönkkäri I. c, Väliaho J. b, Kallio P. b, Ilmarinen T. a, Miettinen S. a, Skottman H. a, Kellomäki M. a, b
Published in: Materials Science and Engineering: C, Vol. 85, 2018, p. 68–78
Corneal blindness is a worldwide problem, plagued by insufficient amount of high-quality donor tissue. Cell therapy using human adipose stem cells (hASCs) has risen as an alternative [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Recognition-driven assembly of self-limiting supramolecular protein nanoparticles displaying enzymatic activity

Publication year: 2015
Authors: Piccinini E. a, Pallarola D. a, Battaglini F. b, Azzaroni O. *a
Published in: Chemical Communications, 2015, Issue 79, p. 14754-7
We report the recognition-driven assembly of self-limiting protein nanoparticles displaying enzymatic activity. Solution self-assembly of concanavalin A lectin and glycoenzyme glucose oxidase leads to [...]

Oligomerization Alters Binding Affinity Between Amyloid Beta and a Modulator of Peptide Aggregation

Publication year: 2017
Authors: Hilt S. 1, Rojalin T. 2, 3, Viitala T. 3, Koivuniemi A.3, Bunker A. 3, Wachsmann-Hogiu S. 2, 4, Kálai T. 5, Hideg K. 5, Yliperttula M. 3, 6, Voss J. C. 1
Published in: The Journal of Physical Chemistry C, 2017, Vol. 121 (43), p. 23974–23987
The soluble oligomeric form of the amyloid beta (Aβ) peptide is the major causative agent in the molecular pathogenesis of Alzheimer’s disease (AD). We have previously developed a pyrroline-nitroxyl fluorene compound (SLF) that blocks [...]