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Antimicrobial alumina nanobiostructures of disulfide- and triazole-linked peptides: Synthesis, characterization, membrane interactions and biological activity

Publication year: 2019
Authors: Torres L.M.F.C. a, Almeida M.T. a, Santos T.L. a, Marinho L.E.S. a, de Mesquita J.P. a, da Silva L.M. a, dos Santos W.T.P. b, Martins H.R. b, Kato K.C. b, Alves E.S.F. c, Liao L.M. c, .de Magalhães M.T.Q d, de Mendonça F.G. e, Pereira F.V. e, Resende J.M. e, Bemquerer M.P. f, Rodrigues M.A. g, Verly R.M. a
Published in: Colloids and Surfaces B: Biointerfaces , 2019, Vol. 177, p. 94-104
Due to the its physical-chemical properties, alumina nanoparticles have potential applications in several areas, such as nanobiomaterials [...]

Self-assembled hybrid nanocomposite films of carbon dots and hydrolyzed collagen

Publication year: 2019
Authors: da Pinto T.S. a, Rodrigues P.N.S. a, Marinho L.E.S. a, Verly R.M. a, Bretas Roa J.P. 1, de Oliveira L.C.Z. b, Pereira F.V. b, de Magalhaes M.T.Q. c,d, de Mesquita J.P. a
Published in: Materials Chemistry and Physics, 2019, Vol. 230, p. 44-53
In the present work, hydrophilic carbon dots (CD) prepared by cotton cellulose were used in the building of self-assembled films with hydrolyzed collagen (CL) to verify [...]

Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures

Publication year: 2019
Authors: Islam N. a,b, Gurgel P.V. a,c, Rojas O.J. a,d, Carbonell R.G. a,e
Published in: Bioconjugate Chemistry, 2019, Vol. 30, p. 815−825
Tris(2-aminoethyl)-amine (TREN), a branched amine, was coupled to planar surfaces of alkanethiol self-assembled monolayers (SAMs) to increase [...]

Enzyme Immobilization in Polyelectrolyte Brushes: High Loading and Enhanced Activity Compared to Monolayers

Publication year: 2019
Authors: del Castillo G.F-D. a, Koenig M. b, Mueller M. b, d, Eichhorn K.-J. b, Stamm M. b,d, Uhlmann P. b,c, Dahlin A. a
Published in: Langmuir, 2019, Vol. 35, p. 3479-3489
Catalysis by enzymes on surfaces has many applications. However, strategies for efficient enzyme immobilization with preserved activity are still in need of further development. [...]

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Publication year: 2019
Authors: Koponen A. a, Arora A. a, Takahashi K. b, Kentala H. a, Kivelä A.M. a, Jääskeläinen E. a, Peränen J. b, Somerharju P. c, Ikonen E. b, Viitala T. d, Olkkonen V.M. a,b
Published in: Biochimie, 2019, Vol. 158, p. 90-101
ORP2 is a sterol-binding protein with documented functions in lipid and glucose metabolism, Akt signaling, steroidogenesis, cell adhesion, migration and proliferation. [...]

Continuous assembly of supramolecular polyamine–phosphate networks on surfaces: preparation and permeability properties of nanofilms

Publication year: 2019
Authors: Agazzi M.L. a, Herrera S.E. a, Cortez M.L. a, Marmisollé W.A. a, von Bilderling C. a,b, Pietrasanta L.I. b,c, Azzaroni O. *a
Published in: Soft Matter, 2019, 15, p. 1640-1650
Supramolecular self-assembly of molecular building blocks represents a powerful “nanoarchitectonic” tool to create new functional materials with molecular-level feature control. Here, we propose [...]

Design and evaluation of a multiplexed angular-scanning surface plasmon resonance system employing line-laser optics and CCD detection in combination with multi-ligand sensor chips

Publication year: 2019
Authors: Lakayan D. a, Tuppurainen J. c, Suutari T.E. a,d, van Iperen D.J. e, Somsen G.W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, 2019, Vol. 282, p. 243-250
An angle-scanning Kretschmann configuration SPR instrument allowing multiplexed analysis is presented. Laser light was guided through optics that converted the collimated light into a line-shaped beam, which was [...]

The sensitive detection of ODAM by using sandwich-type biosensors with a cognate pair of aptamers for the early diagnosis of periodontal disease

Publication year: 2019
Authors: Lee B.H. 1, Kim S.H. 1, Ko Y. 2, Park J.C. 3, Ji S. 4, Gu M.B. 5
Published in: Biosensors and Bioelectronics, 2019, Vol. 126, p. 122-128
This research aims to develop biosensors which could diagnose periodontal diseases in early phases and predict the illness stage of patients, in order to give them adequate treatment timely. [...]

Analytical Model To Describe the Effect of Polyethylene Glycol on Ionic Screening of Analyte Charges in Transistor-Based Immunosensing

Publication year: 2019
Authors: Haustein N., Gutierrez-Sanz O., Tarasov. A
Published in: ACS Sensors, 2019, Vol. 4, Issue 4, p. 874-882
Recently, the co-immobilization of polyethylene glycol has improved sensor responses of transistor-based immunosensing by approximately three times. However, there is currently [...]

Antibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes

Publication year: 2019
Authors: Ierich J.C.M. 1,2, Brum D.G. 3, Moraes A.S. 1,2, Higa A.M. 1,2, Garcia P.S. 1,2, Miyazaki C.M. 4, Ferreira M. 4, Peroni L.A. 5, Oliveira G.S. 6, Franca E.F. 6, Freitas L.C.G. 7, Leite F.L. 8
Published in: Scientific Reports, 2019, Vol. 9, Issue 1, p. 2033
Antigen-antibody interaction is crucial in autoimmune disease pathogenesis, as multiple sclerosis and neuromyelitis optica. Given that, autoantibodies are essential [...]

Carboxyl-rich plasma polymer surfaces in surface plasmon resonance immunosensing

Publication year: 2018
Authors: Makhneva E. 1, 2, 6, Obrusnik A. 1, 2, 6, Farka Z. 3, Skladal P. 3, 4, Vandenbossche M. 5, Hegemann D. 5, Zajickova L. 1, 2
Published in: Japanese Journal of Applied Physics, 2018, Vol. 57, Number 1S, 01AG06
Stable carboxyl-rich plasma polymers (PPs) were deposited onto the gold surface of surface plasmon resonance (SPR) chips under conditions that were chosen based on lumped kinetic model results. Carboxyl-rich films are [...]

Cascading reaction of arginase and urease on a graphene-based FET for ultrasensitive, real-time detection of arginine

Publication year: 2018
Authors: Berninger T. a, Bliem C. a, Piccinini E. b, Azzaroni O. b, Knoll W. a
Published in: Biosensors and Bioelectronics, 2018, Vol. 115, p. 104-110
Herein, a biosensor based on a reduced graphene oxide field effect transistor (rGO-FET) functionalized with the cascading enzymes arginase and urease was developed for the detection of L-arginine. Arginase [...]

Enzyme Multilayers on Graphene-Based FETs for Biosensing Applications

Publication year: 2018
Authors: Bliem C. a, Piccinini E. b, Knoll W. a, Azzaroni O. b
Published in: Methods in Enzymology, 2018, Vol. 609, p. 23-46
Electrochemical sensors represent a powerful tool for real-time measurement of a variety of analytes of much significance to different areas, ranging from clinical diagnostics to food technology. [...]

Affinity maturation and characterization of the ofatumumab monoclonal antibody

Publication year: 2018
Authors: Payandeh Z. 1, Rajabibazl M. 2,3, Mortazavi Y. 1,4, Rahimpour A. 3, Taromchi A.H. 1,4, Dastmalchi S. 5,6
Published in: Journal of Cellular Biochemistry, 2018
CD20 molecule, a phosphoprotein with 297 amino acids and four transmembrane domains, is a member of MS4A protein family. Anti-CD20 antibodies such as ofatumumab, which have been developed [...]

Development of a surface plasmon resonance sensor for coupling to capillary electrophoresis allowing affinity assessment of protein mixture components

Publication year: 2018
Authors: Domínguez-Vega E. a, Haselberg R. a, van Iperen D. b, Kool J. a, Somsen G.W. a, de Jong G.J. c
Published in: Sensors and Actuators B: Chemical, 2018, Vol. 254, p. 1040-1047
Surface plasmon resonance (SPR) currently is the major platform to study protein–protein interactions, but it lacks the selectivity o distinguish between binding components within one sample. [...]

Characterization of membrane–foulant interactions with novel combination of Raman spectroscopy, surface plasmon resonance and molecular dynamics simulation

Publication year: 2018
Authors: Virtanen T. a, Parkkila P. b, Koivuniemi A. b, Lahti J. a, Viitala T. b, Kallioinen M. a, Mänttäri M. a, Bunker A. b
Published in: Separation and Purification Technology, 2018, Vol. 5, p. 263-272
Adsorptive fouling, by phenolic compounds, is a serious issue regarding the development and use of membrane based filtration technologies for water [...]

High-generation amphiphilic Janus-dendrimers as stabilizing agents for drug suspensions

Publication year: 2018
Authors: Selin M. 1, Nummelin S. 2, Deleu J. 1,3, Ropponen J. 4, Viitala T. 5, Lahtinen M. 6, Koivisto J. 7, Hirvonen J. 1, Peltonen L. 1, Kostinainen M.A. 2,8, Bimbo L.M. 1,9
Published in: Biomacromolecules, 2018, Vol. 19 (10), p. 3983–3993
Pharmaceutical nanosuspensions are formed when drug crystals are suspended in aqueous media in the presence of stabilizers. This technology offers a convenient way to enhance [...]

Salt-Induced Control of the Grafting Density in Poly(ethylene glycol) Brush Layers by a Grafting-to Approach

Publication year: 2018
Authors: Ortiz R. 1, Olsen S. 2, Thormann E. 1
Published in: Langmuir, 2018, Vol. 34(15), p. 4455-4464
In this work, a method to obtain control of the grafting density during the formation of polymer brush layers by the grafting-to method of thiolated poly(ethylene glycol) onto gold is presented. The grafting density [...]

Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements

Publication year: 2018
Authors: Parkkila P. 1, Elderfi M. 2, Bunker A. 1, Viitala T. 1
Published in: Langmuir, 2018, Vol. 34 (27), p. 8081-8091
Supported lipid bilayers (SLBs) have been used extensively as an effective model of biological membranes, in the context of in vitro biophysics research, and the membranes of liposomes, [...]

A DNA–nanoparticle actuator enabling optical monitoring of nanoscale movements induced by an electric field

Publication year: 2018
Authors: Tapio K. a, Shao D. a, Auer S. b, Tuppurainen J. c, Ahlskog M. a, Hytönen V.P. b, Toppari J.J. a*
Published in: Nanoscale, 2018, Vol. 10, p. 19297-19309
Merging biological and non-biological matter to fabricate nanoscale assemblies with controllable motion and function is of great interest due to its potential application, for example, in diagnostics and biosensing. [...]