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Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Publication year: 2018
Authors: Magarkar A. a,b, Parkkila P. a, Viitala T. a, Lajunen T. a, Mobarak E. c,d, Licari G. e, Cramariuc O. c, Vauthey E. e , Rógc T. d, Bunker A.* a
Published in: Chemical Communications, 2018, Vol. 54, Issue 28, p. 3440-3443
The enzyme catechol-O-methyltransferase (COMT) has water soluble (S-COMT) and membrane associated (MB-COMT), bitopic, isoforms. Of these MB-COMT is a drug target [...]

Phage display selection of fully human antibody fragments to inhibit growth-promoting effects of glycine-extended gastrin 17 on human colorectal cancer cells

Publication year: 2018
Authors: Khajeh S .1,2, Tohidkia M.R. 2, Aghanejad A. 2, Mehdipour T. 2, Fathi F. 2, Omidi Y. 2
Published in: Artificial Cells, Nanomedicine and Biotechnology, 2018, Vol. 46
Glycine-extended gastrin 17 (G17-Gly), a dominant processing intermediate of gastrin gene, has been implicated in the development or maintenance of colorectal cancers (CRCs). [...]

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor

Publication year: 2018
Authors: Xiang Y. 1, Halin J. 2, Fan Z. 1, Hu S. 1, Wang M. 1, Qiu L. 1, Zhang Z. 3, Mattjus P. 2, Zhang Y. 1
Published in: bioRxiv, 2018
The topobiological behaviour of Nrf1 dictates its post-translational modification and its ability to transactivate target genes. Here, we have elucidated that topovectorial mechanisms control [...]

Angular scanning and variable wavelength surface plasmon resonance allowing free sensor surface selection for optimum material- and bio-sensing

Publication year: 2018
Authors: Lakayan D. a, b, Tuppurainen J. c, d, Albers M. c, d, van Lint M. J. e, van Iperen D. J. f, Weda J. J. A. g, Kuncova-Kallio J. c, d, Somsen G. W. a, Kool J. a
Published in: Sensors and Actuators B: Chemical, Vol. 259, 15, 2018, p. 972–979
A variable-wavelength Kretschmann configuration surface plasmon resonance (SPR) apparatus with angle scanning is presented. The setup provides the possibility of [...]

Volume expansion of erythrocytes is not the only mechanism responsible for the protection by arginine-based surfactants against hypotonic hemolysis

Publication year: 2018
Authors: Fait M.E. 1, Hermet M. 1, Vazquez R. 2, Mate S. 2, Daza Millone M.A. 3, Vela M.E. 4, Morcelle S.R. 5, Bakas L. 6
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 171, p. 134-141
A novel arginine-based cationic surfactant Nα-benzoyl-arginine dodecylamide (Bz-Arg-NHC12) was synthesized in our laboratory. In this paper we study the interaction of [...]

A facile molecularly imprinted polymer-based fluorometric assay for detection of histamine

Publication year: 2018
Authors: Feng X., Ashley J., Zhou T., Halder A., Sun Y.
Published in: RSC Advances, 2018, Vol. 8, Issue 5, p. 2365
Histamine is a biogenic amine naturally present in many body cells. It is also a contaminant that is mostly found in spoiled food. The consumption of foods containing high levels [...]

Dispersive solid-phase imprinting of proteins for the production of plastic antibodies

Publication year: 2018
Authors: Ashley J., Feng X., Halder A., Zhou T., Sun Y.*
Published in: Chemical Communications, 2018, Vol. 54 (27), p. 3355-3358
We describe a novel dispersive solid-phase imprinting technique for the production of nano-sized molecularly imprinted polymers (nanoMIPs) as plastic antibodies. The template [...]

Urea and creatinine detection on nano-laminated gold thin film using Kretschmann-based surface plasmon resonance biosensor

Publication year: 2018
Authors: Menon P.S., Said F.A., Mei G.S., Berhanuddin D.D., Umar A.A., Shaari S., Majlis B.Y.
Published in: PLoS One, 2018, Vol. 13 (7)
This work investigates the surface plasmon resonance (SPR) response of 50-nm thick nano-laminated gold film using Kretschmann-based biosensing for detection of urea [...]

On the Importance of Controlling Film Architecture in Detecting Prostate Specific Antigen

Publication year: 2018
Authors: Graça J. S. a, Miyazaki C. M. a, Shimizu F. M. b, Volpati D. c, Mejía-Salazar J. R. b, Oliveira O.N. Jr. b, Ferreira M. a
Published in: Applied Surface Science, 2018, Vol. 434, p. 1175-1182
Immunosensors made with nanostructured films are promising for detecting cancer biomarkers, even at early stages of the disease, but this requires control of film architecture to preserve [...]

Bovine serum albumin binding study to erlotinib using surface plasmon resonance and molecular docking methods

Publication year: 2018
Authors: Taghipour P. 1, Zakariazadeh M. 2, Sharifi M. 3, Ezzati Nazhad Dolatabadi J. 4, Barzegar A. 5
Published in: Journal of Photochemistry and Photobiology B, 2018, Vol. 183, p. 11-15
Bovine serum albumin (BSA) is the most abundant protein in the blood circulation and it is commonly used for drug delivery in blood. Therefore, we aim to study BSA interaction with erlotinib [...]

Dynamic dispersal of surface layer biofilm induced by n-TiO2 based on surface plasmon resonance and waveguide

Publication year: 2018
Authors: Zhang P. 1,2, Guo J.S. 3, Yan P. 2, Chen Y.P. 4,2, Wang W. 5, Dai Y.Z. 1, Fang F. 2, Wang G.X. 6, Shen Y. 7
Published in: Applied and Environmental Microbiology, 2018
Pollutant degradation is mainly presented in the surface layer of biofilm, while the surface layer is the most vulnerable to the impairment of toxic pollutants. In this work, the effect of nanosized TiO2 [...]

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Publication year: 2018
Authors: Casteleijn M. G. a, Richardson D. a, Parkkila P. a, Granqvist N. b, Urtti A. a, c, Viitala T. a
Published in: Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, Vol. 539, p. 261-272
Chitin, abundant in nature, is a renewable resource with many possible applications in bioengineering. Biosensors, capable of label-free and in-line evaluation, play an important role in the investigation of [...]

Generation and validation of murine monoclonal and camelid recombinant single domain antibodies specific for human pancreatic glycoprotein 2

Publication year: 2018
Authors: Schlör A. a, Holzlöhner P. a, Listek M. a, Griess C. a, Butze M. a, Micheel B. a, Hentschel Ch. b, Sowa M. b, Roggenbuck D. b,c, Schierack P. c, Füner J. d, Schliebs E. d, Goihl A. e, Reinhold D. e, Hanack K. a
Published in: New Biotechnology, 2018
Pancreatic secretory zymogen-granule membrane glycoprotein 2 (GP2) has been identified as a major autoantigenic target in Crohn’s disease patients. It was reported recently that a long (GP2a) and a short (GP2b) isoform [...]

Two-dimensional label-free affinity analysis of tumor-specific CD8 T cells with a biomimetic plasmonic sensor

Publication year: 2018
Authors: Soler M. 1, Li X. 1, John-Herpin A. 1, Schmidt J. 2, Coukos G. 2, Altug H. 1
Published in: ACS Sensors, 2018
The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity [...]

Stable, nanometer‐thick oxygen‐containing plasma polymer films suited for enhanced biosensing

Publication year: 2018
Authors: Hegeman D. 1, Indutnyi I. 2, Zajickova L. 3,4, Makhneva E. 3,4, Farka Z. 3, Ushenin Y. 2, Vandenbossche M. 1
Published in: Plasma Processes and Polymers, 2018, e1800090
Stable surface functionalization is required in many applications such as in biosensing. For this purpose, hydrocarbon‐based plasma polymer films (PPFs) were investigated by controlling cross‐linking [...]

Label-free biosensors in the field of stem cell biology

Publication year: 2018
Authors: Fathi F. a, Rahbarghazi R. b, c, Rashidi M.-R. a, d
Published in: Biosensors and Bioelectronics, 2018, Vol. 101, p. 188-198
A great body of evidence unveiled the existence of different stem cell types in various tissues with efficient capability for self-renewal and differentiation. Characterization and enumeration [...]

Advancing Peptide-Based Biorecognition Elements for Biosensors Using In-Silico Evolution

Publication year: 2018
Authors: Xiao X. 1, Kuang Z. 2, Slocik J.M. 2, Tadepalli S. 4, Brothers M. 3, Kim S. 3, Mirau P.A. 2, Butkus C. 2, Farmer B.L. 2, Singamaneni S. 4, Hall C.K. 1, Naik R.R. 3
Published in: ACS Sensors, 2018, Vol. 3, Issue 5, p. 1024–1031
Sensors for human health and performance monitoring require biological recognition elements (BREs) at device interfaces for the detection of key molecular biomarkers that are measurable biological state indicators. [...]

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Publication year: 2018
Authors: Ylösmäki E. 1, Malorzo C. 1, Capasso C. 1, Honkasalo O. 1, Fusciello M. 1, Martins B. 1, Ylösmäki L. 1, Louna A. 2, Feola S. 1, Paavilainen H. 3, Peltonen K. 1, Hukkanen V. 3, Viitala T. 2, Cerullo V. 4
Published in: Moleuclar Theraphy, 2018, Vol. 9, p. 2315-2325
The approval of the first oncolytic virus for the treatment of metastatic melanoma and the compiling evidence that the use of oncolytic viruses can enhance cancer immunotherapies targeted [...]

Phase-segregated Membrane Model assessed by a combined SPR-AFM Approach

Publication year: 2018
Authors: Millone D.A.M. 1, Vázquez R.F. 1, Maté S.M. 2, Vela M.E. 3
Published in: Colloids and Surfaces B: Biointerfaces, 2018, Vol. 172, p. 423-429
Model biomembranes can provide valuable insights into the properties of complex biological membranes. Among several techniques, Surface Plasmon Resonance (SPR) provides [...]

Kinetic and thermodynamic studies of bovine serum albumin interaction with ascorbyl palmitate and ascorbyl stearate food additives using surface plasmon resonance

Publication year: 2018
Authors: Fathi F. a, Mohammadzadeh-Aghdash H. b, c, Sohrabi Y. b, c, Dehghan P. b, Ezzati J. N. D. a
Published in: Food Chemistry, 2018, Vol. 246, p.228-232
Ascorbyl palmitate (AP) and ascorbyl stearate (AS) are examples of food additives, which have extensive use in food industry. In this study, we evaluated the interaction of bovine serum albumin (BSA) with [...]