Electrochemistry for biosensing

Take your electrochemical biosensors development a step further with MP-SPR NaviTM !

Electrochemical biosensors hold a great promise for future point-of-care testing. They can be miniaturized and easily mass produced. Research is ongoing in the field of printed biosensors, for instance, that would enable cheap disposable biosensors on paper. Already now, electrochemical biosensors are widely used for fast biomolecular detection in blood glucose level monitoring. Typical configurations of electrochemical sensors are amperometric and potentiometric. 

MP-SPR NaviTM instrument can be equipped with an electrochemical cuvette. Such configuration enables highly advantageously simultaneous MP-SPR and electrochemical measurements providing tools to

  • to develop a sensitive assay
  • to select best molecules
  • to select best electrode material
  • to improve electrode manufacturing
  • to select best coating for electrodes
  • to finetune microfluidic channel coatings

The picture shows an MP-SPR configuration with an electrochemical cuvette and positioning of the electrodes. On the right side, signals from both instruments are shown - the MP-SPR signal and the AV scan.

A potentiostat is connected to the MP-SPR electrochemistry cuvette. The cuvette contains an internal reference electrode, a counter electrode and a working electrode. MP-SPR NaviTM standard flow-cell can be exchanged to an electrochemistry cuvette in a minute thanks to an easily accessible flow-cell release button. The combination of MP-SPR and electrochemistry (“EC-SPR”) allows sensitive, real-time monitoring of adsorbing and desorbing species during electrochemical experiments, or other small surface changes caused by electric potential changes applied to the surface. The unique MP-SPR optical setup provides information not only about binding but also layer properties such as thickness and refractive index.

See application examples!