Combining MP-SPR and electrochemistry in life sciences

MP-SPR method can be used in conjunction with a variety of electrochemical techniques for gathering both optical and electrochemical real-time data simultaneously from the same reaction. Multiple electrochemical methods, such as potentiometric, amperometric or impedance spectroscopy can be measured.

A potentiostat can be used both to induce reactions on surface (electrochemical switching) or to gather information with a technology sensitive to other type of information than optical changes.

Five typical research areas to combine electrochemistry and MP-SPR:

See five reasons to choose MP-SPR for EC biosensor development: 

  • Easy ex-situ modification of SPR surfaces
  • Any assay type
  • Any sample
  • Easy validation
  • Microfluidic material testing

See five key questions in electrochemical biosensor development that MP-SPR can answer:

  • How fast do the molecules X bind with surface A as compared to surface B?
  • What is the optimum surface for my biosensor applications?
  • How does my assay work with crude sample such as serum, saliva, sea water or urine?
  • Is the biosensor I have designed working better than the previous one?
  • Which coating prevents sample adsorption onto my microfluidic channels?

See selected Application Notes to see that MP-SPR works:

  • AN#143 Real-time monitoring of antibody binding by parallel MP-SPR, potentiometry and impedance spectroscopy
  • AN#142 Real-time monitoring of metal stripping and deposition with EC-MP-SPR
  • AN#136 Polymer collapse due to pH or electric potential change monitored with MP-SPR
  • AN#140 Self-assembly of gold nanoparticles measured with MP-SPR

Selected publications:

Electrochemical sensor development using MP-SPR:

Printed biosensor development using MP-SPR:

Electroswitchable surfaces:

What our users say about MP-SPR for electrochemical biosensor development:

"It is essential that we can prepare our own biosensing surfaces in-situ and ex-situ and test them with electrochemistry-enabled MP-SPR."
Dr. Adama Sesay, Center for Measurement and Information Systems, University of Oulu, Finland



See five reasons to choose MP-SPR for electrochemical studies.