MP-SPR for drug delivery

 

Drug delivery is an essential part of the drug formulation process. With novel biopharmaceuticals, the internalization of a drug has to be facilited by nanodrug carriers. Also novel gel and patch formulations require deep understanding of drug-nanoparticle, nanoparticle-target, nanoparticle-living cell interaction as well as release of drug from material.

Nanoparticles for drug delivery and for contrast agents are typically made of polymers, silica, metals, liposomes, viruses, DNA polyplexes and newly also exosomes and other microvesicles.

See five reasons to choose MP-SPR for drug delivery studies:

  • Size does not matter
  • From targeting to internalization studies
  • Aggregating nanoparticles? Just try MP-SPR!
  • From static to dynamic measurements of nanoparticles
  • From SEM to MP-SPR and back to SEM

See five key questions about drug delivery that MP-SPR can answer:

  • What is the best nanoparticle for drug delivery?
  • What is the absorption route of a drug nanocarrier?
  • How does nanoparticle X interact with lipid bilayer?
  • What is the release rate of drug X from material Y?
  • How does a nanoparticle or virus enter the cell?

See selected Application Notes to see that MP-SPR works:

  • AN#152 Drug Delivery Nanocarrier Studies Using MP-SPR
  • AN#151 MP-SPR Measurements of Soft and Hard Corona on Nanoparticle in 100% Serum
  • AN#145 Virus interaction studies using MP-SPR
  • AN#140 Binding of gold nanoparticles to self-assembled monolayer
  • AN#139 Liposomes attachment on the sensor surface – thickness and refractive index ensure the layer conformation
  • AN#137 Drug - living cell interaction
  • AN#129 Effect of hydrodynamic flow on the interaction kinetics of targeted drug delivery systems

Selected publications:

What our users say about MP-SPR for nanoparticle measurements:

"With MP-SPR, we are able to observe and quantify the differences in cell uptake kinetics of nanoparticles in dependence with the surface characteristics of the nanoparticle and their targeting." - Asst. Prof. Tapani Viitala, University of Helsinki, Finland

 


 

See five reasons to choose MP-SPR for drug delivery studies.