Why choose MP-SPR for biosensor development?

 

Ex-situ modification of SPR sensor surfaces

Avoid costly assay transfer - develop your sensor directly on your sensing material: metals for electrochemical (EC) and SPR detection, plastics for ELISA, cellulose for printed biosensors, metal nanoparticles for SERS, glass for classical chemistry, magnetic nanoparticles, bacteria, living cells and more.

MP-SPR instruments do not require refractive index oil and thanks to a fast locking holder for sensors, there is no need for two-sided tape either. Sensors can be functionalized in-situ or ex-situ with a number of methods including spin-coating, dip coating, Langmuir Blodgett, ALD, sputtering, CVD, etc.

Reuse of our sensors is possible. Our gold sensors use a superior adhesion layer that allows for repeated cleaning with strong acids. We provide many other sensor surfaces including SiO2, TiO2, Pt, but also functionalized surfaces, such as carboxymethyl dextran, protein A, HisTag and more.

Any assay type

MP-SPR shows you every step of your assay, whether it is direct binding, competitive assays, it uses antibodies, fragments, DNA, molecularly imprinted polymers (MIPs), aptamers, nanoparticles, cells or microvesicles. MP-SPR as the only one in the market is able to quantify also conformational changes using LayerSolver and measurements at multiple wavelengths.

Any sample

MP-SPR works with gas, vapour or liquid samples. The samples can be purified or crude including saliva and whole serum. The sample can contain even metallic nanoparticles and still be measured by MP-SPR.

Easy validation

In-situ validation is possible with electrochemistry, fluorescence, and other optical detection methods. Ex-situ validation is possible with microscopy including AFM and SEM. If you are specifically interested in combination of electrochemical and MP-SPR measurements, please see this section dedicated to MP-SPR-EC.

Microfluidics

Often new biosensors utilize microfluidics to minimize sample consumption and to reduce the analysis time. Microfluidic chips can be made in polymers, silica, metals, glass or even paper. It is essential to coat the microchannels in order to prevent sample adsorption onto the channel surface instead, and thus to prevent reduction of the analyte concentration in the sample. MP-SPR can be used to optimize microfluidic surfaces to provide wetting, yet antifouling surface. 


 

Recommended MP-SPR instruments for biosensor development:

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