BioNavis: Excellence in Surface Plasmon Resonance

SPR Navi™ instruments have been developed for surface analysis in a number of key application areas, expanding the use of SPR from biomolecular interactions to new applications such as material characterization and sensor development. 

 

MP-SPR: The new generation of SPR

SPR Navi™ represents a generation shift in surface plasmon resonance (SPR) technology. The new Multi-Parametric SPR solves some of the previously open-ended questions and enables measurements on a number of samples, surfaces and conditions, traditional SPR cannot.

SPR Navi™: The only MP-SPR instruments on the market!

  • Real-time molecular interactions (kinetics, on-/off-rates, adsorption, desorption, affinity, concentration, adhesion
  • Physical properties (thickness, swelling, adsorbed mass) 
  • Optical properties (complex refractive index) 
  • Electrochemical behavior

on polymers, metals, alloys, ceramics, organic layers (incl. graphene, SiO2, TiO2, cell layers, Pt, Cu, cellulose, PET, PP, nanoparticles,..)
ranging from a few Ångströms to a few microns in thickness and
interacting with samples in gas and liquid environment.

Key Questions that SPR Navi™ can answer

Life Sciences

  • What is the affinity and on- and off-rates for molecule X interacting with protein Y?
  • How does this surface/analyte interaction change when the electrical potential is changed? 

Material Science

  • How does this polyelectrolyte multilayer grow?
  • How thick is the monolayer and what is the refractive index?
  • What is the thickness and refractive index of the nanolayers in the nanolaminate?

Sensor Development

  • Is the biosensor that I have designed working better than the previous one?
  • How does the surface of my biosensor interact with sample X?

Testimonials

"It is essential for us to decouple the contribution of hydration and bound water for quantification of adsorbed mass, layer thickness, etc."

Prof. Orlando Rojas
NCSU, USA and Aalto University, Finland

"With MP-SPR, we are able to observe and quantify the differences in cell uptake and kinetics of nanoparticles in dependence with the surface characteristics of the nanoparticle and their targeting."

Academy Research Fellow,
Tapani Viitala
University of Helsinki, Finland 

"MP-SPR is flexible instrument that allows us to connect the power of traditional separation techniques, such as LC, with the quantification of interactions by SPR."

Dr. Jeroen Kool
VU Amsterdam, The Netherlands 

"We use MP-SPR to quantify conformation changes of proteins at the surface under different environmental conditions."

Prof. Barbara Jachimska
Polish Academy of Sciences, Poland 

Specifications

  • SPR angle range: 40° - 78°
  • Refractive index (RI) range: 1.00 - 1.40+
  • Smalles detected molecule: 2 Da (hydrogen measured in gas)
  • Largest detected: cells, liposomes, nanoparticles
  • Sensitivity: picomolar real-time label-free, attomolar with a color dye
  • Fastest sampling rate: from 4 ms
  • Measurable layer thickness: 5 Å -100 nm and 300 nm to µms

Accessories and Consumables

  • Additional set of lasers enabling true RI and thickness measurements, work with cell monolayers and extending the working range
  • Flow cells: standard (PDMS), electrochemistry, high chemical resistance (PEEK), gas
  • Sensor slides: Au-coated, metallic, non-metallic, carboxymethyldextran, custom
  • Software for SPR Navi™

 

SPR Navi™? SPR Navi™!

NOTE OUR NEW ADDRESS!! Oy BioNavis Ltd, Elopellontie 3C, 334 70 Ylöjärvi, FINLAND +358 44 5872001, info(...@...)bionavis.com

LATEST NEWS

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Event Date/Time
2014 MRS Fall Meeting & Exhibit November 30, 2014 to December 05, 2014
BioNavis is going to participate at 2014 MRS Fall Meeting & Exhibit that takes place on November 30 - December 5, 2014 in Boston, Massachusetts.The 2014 MRS Fall Meeting and Exhibit will feature over 6 000 presentations, including more than 3 300 or...
Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014) December 07, 2014 to December 11, 2014
BioNavis is going to participate at Pacific Rim Symposium on Surfaces, Coatings and Interfaces (PacSurf 2014) that will be held on the Big Island of Hawaii from December 7 - 11, 2014. The main topics for PacSurf 2014 will...

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