BioNavis: Excellence in Surface Plasmon Resonance

SPR Navi™ instruments have been developed for surface analysis in a number of key application areas, expanding the use of SPR from biomolecular interactions to new applications such as material characterization and sensor development. 

 

MP-SPR: The new generation of SPR

SPR Navi™ represents a generation shift in surface plasmon resonance (SPR) technology. The new Multi-Parametric SPR solves some of the previously open-ended questions and enables measurements on a number of samples, surfaces and conditions, traditional SPR cannot.

 

SPR Navi™: The only MP-SPR instruments on the market!

  • Real-time molecular interactions (kinetics, on-/off-rates, adsorption, desorption, affinity, concentration, adhesion
  • Physical properties (thickness, swelling, adsorbed mass) 
  • Optical properties (complex refractive index) 
  • Electrochemical behavior

on polymers, metals, alloys, ceramics, organic layers (incl. graphene, SiO2, TiO2, cell layers, Pt, Cu, cellulose, PET, PP, nanoparticles,..)
ranging from a few Ångströms to a few microns in thickness and
interacting with samples in gas and liquid environment.

Key Questions that SPR Navi™ can answer

Life Sciences

  • What is the affinity and on- and off-rates for molecule X interacting with protein Y?
  • How does this surface/analyte interaction change when the electrical potential is changed? 

Material Science

  • How does this polyelectrolyte multilayer grow?
  • How thick is the monolayer and what is the refractive index?
  • What is the thickness and refractive index of the nanolayers in the nanolaminate?

Sensor Development

  • Is the biosensor that I have designed working better than the previous one?
  • How does the surface of my biosensor interact with sample X?

Testimonials

"It is essential for us to decouple the contribution of hydration and bound water for quantification of adsorbed mass, layer thickness, etc."

Prof. Orlando Rojas
NCSU, USA and Aalto University, Finland

"With MP-SPR, we are able to observe and quantify the differences in cell uptake and kinetics of nanoparticles in dependence with the surface characteristics of the nanoparticle and their targeting."

Academy Research Fellow,
Tapani Viitala
University of Helsinki, Finland 

"MP-SPR is flexible instrument that allows us to connect the power of traditional separation techniques, such as LC, with the quantification of interactions by SPR."

Dr. Jeroen Kool
VU Amsterdam, The Netherlands 

"We use MP-SPR to quantify conformation changes of proteins at the surface under different environmental conditions."

Prof. Barbara Jachimska
Polish Academy of Sciences, Poland 

Specifications

  • SPR angle range: 40° - 78°
  • Refractive index (RI) range: 1.00 - 1.40+
  • Smalles detected molecule: 2 Da (hydrogen measured in gas)
  • Largest detected: cells, liposomes, nanoparticles
  • Sensitivity: picomolar real-time label-free, attomolar with a color dye
  • Fastest sampling rate: from 4 ms
  • Measurable layer thickness: 5 Å -100 nm and 300 nm to µms

Accessories and Consumables

  • Additional set of lasers enabling true RI and thickness measurements, work with cell monolayers and extending the working range
  • Flow cells: standard (PDMS), electrochemistry, high chemical resistance (PEEK), gas
  • Sensor slides: Au-coated, metallic, non-metallic, carboxymethyldextran, custom
  • Software for SPR Navi™

 

SPR Navi™? SPR Navi™!

NOTE OUR NEW ADDRESS!! Oy BioNavis Ltd, Elopellontie 3C, 334 70 Ylöjärvi, FINLAND +358 44 5872001, info(...@...)bionavis.com

LATEST NEWS

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Event Date/Time
NanoSpain 2015 March 10, 2015 to March 13, 2015
BioNavis is going to participate at NanoSpain 2015 that takes place on March 10-13, 2015, in Bilbao, Spain. NanoSpain 2015 has been organized over the past 11 years and is a reference meeting of Nanoscience and Nanotechnology (N&N) in Spain. Ove...
LabelFree Technologies March 12, 2015, 12:00 am to March 14, 2015, 1:00 pm
BioNavis is going to participate at LabelFree Technologies that takes place on March 12-14, 2015, in Cambridge (Massachusetts), USA. Label-Free Technologies is a two-and-a-half-day conference focused on the latest advances and applications of label-free t...
249th ACS National Meeting & Exposition - Chemistry of Natural Resources March 22, 2015 to March 26, 2015
BioNavis is going to participate at 249th ACS National Meeting & Exposition - Chemistry of Natural Resources that takes place on March 22-26, 2015, in Denver (Colorado), USA. Thousands of chemical professionals will come together for this event t...

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